Severe Vitamin D Deficiency in Saudi Patients with Type 2 Diabetes Mellitus

Aljabri, Khalid S; Bokhari, Samia A

doi:10.14302/issn.2574-450x.jom-19-2987

Cited by 3 publications

(7 citation statements)

References 53 publications

(48 reference statements)

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“…Similar to the current study, they reported a significant association between VDD and several risk factors, including age, gender, and HbA1c among people with diabetes. [20] In contrast to the present study, they also reported a significant association between VDD and gender among people with diabetes. [20] Our study found 97.8% of the diabetic subjects had VDD and significantly lower levels of vitamin D. Another study reported 64.3% of subjects with VDD were among people with diabetes; however, VDD did not significantly affect correlations with BMI, weight, or height, as opposed to the present study.…”

Section: Discussioncontrasting

confidence: 99%

“…[20] In contrast to the present study, they also reported a significant association between VDD and gender among people with diabetes. [20] Our study found 97.8% of the diabetic subjects had VDD and significantly lower levels of vitamin D. Another study reported 64.3% of subjects with VDD were among people with diabetes; however, VDD did not significantly affect correlations with BMI, weight, or height, as opposed to the present study. [21] In contrast to the results of present study, a study found no statistically significant difference in the mean values of vitamin D among diabetics and nondiabetics.…”

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

“…[ 20 ] In contrast to the present study, they also reported a significant association between VDD and gender among people with diabetes. [ 20 ]…”

Section: Discussioncontrasting

confidence: 99%

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Determinants of Vitamin D deficiency among type 2 diabetes mellitus patients: A retrospective study

Alzahrani,

Baig,

Yaghmour

et al. 2024

Medicine

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Recent studies have shown an association between vitamin D deficiency (VDD) and type 2 diabetes mellitus patients (T2DM), but the precise relationship between these conditions has yet to be clarified. In this study, we aimed to estimate the incidence of VDD among diabetic patients and identify any relationship between diabetes and the determinants of VDD among T2DM individuals. A retrospective cross-sectional study was conducted at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Patients of either gender were selected from electronic records and checked for vitamin D levels, glycosylated hemoglobin (HbA1c), and other parameters. A total of 864 subjects were enrolled. Subjects were grouped according to HbA1c levels, with < 5.7%, 5.7% to 6.49%, and > 6.5% considered normal, impaired, and diabetic, respectively. VDD was common, with an incidence of 723 (83.7%) subjects. A significantly lower vitamin D level was found in diabetic subjects than in nondiabetic subjects (29.1 ± 12.0 vs 44.0 ± 28.3, P < .001). A total of 207/209 (99%) subjects with impaired HbA1c and 179/183 (97.8%) people with diabetes had VDD. Interestingly, none of the diabetic or impaired HbA1c subjects had normal vitamin D levels. A significant association was found between VDD and being > 50 years old, overweight, or obese, as well as HbA1c, fasting plasma glucose, calcium, and total cholesterol (TC) levels. A high rate of VDD and significantly lower vitamin D levels were found in diabetic subjects. Age, being overweight, obesity, HbA1c, and fasting plasma glucose were the few determinants of VDD among T2DM patients. These findings highlight the importance of addressing vitamin D status in managing and preventing T2DM, particularly in those over the age of 50, those who have higher body weight, and those with raised HbA1c and fasting plasma glucose levels.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

“…[ 20 ] In contrast to the present study, they also reported a significant association between VDD and gender among people with diabetes. [ 20 ]…”

Section: Discussioncontrasting

confidence: 99%

See 2 more Smart Citations

Determinants of Vitamin D deficiency among type 2 diabetes mellitus patients: A retrospective study

Alzahrani,

Baig,

Yaghmour

et al. 2024

Medicine

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“…[33][34][35] Sadat-Ali et al 34 reported a 37% prevalence of vitamin D deficiency in healthy men in eastern Saudi Arabia. Aljabri et al 36 reported a 27% prevalence of vitamin D deficiency in patients with T2DM in Saudi Arabia. The current study reported normal serum vitamin D levels and vitamin D insufficiency in 46.6% (≥30ng/mL) and 43.9% (20.1-29.9 ng/mL) of patients with T2DM, respectively.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Vitamin-D Deficiency with Kidney Disease in Patients with Type-2 Diabetes Mellitus (T2DM) in the Makkah Region: A Cross-Sectional Study

Obaid,

Mujalli,

Farrash

et al. 2024

DMSO

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Aim Vitamin D deficiency is linked with type 2 diabetes mellitus (T2DM) and the occurrence of complications in patients with type 2 diabetes mellitus. None of the studies have focused on the association between vitamin D levels in patients with type 2 diabetes mellitus and diabetic nephropathy (DN) in the Makkah region, Saudi Arabia. Hence, the purpose of this study is to investigate the relationship of vitamin D with kidney disease in patients with T2DM in the Makkah region, of Saudi Arabia. Materials and Methods This descriptive cross-sectional study was conducted at different hospitals in the Makkah region on T2DM patients from 2021 to 2022. In total, 328 patients with confirmed diabetes were enrolled in this study. T2DM patients over the aged>18 to 92 years were included in the study. General laboratory characteristics of the study population were measured, including fasting blood sugar, HbA1C (Glycated hemoglobin), vitamin D, kidney function (BUN-Blood urea nitrogen and creatinine), and lipid profiles (cholesterol, triglycerides, LDL-Low density lipoprotein, and HDL-High density lipoprotein). Results 46.6% (n=153) of participants had normal serum vitamin D levels. Insufficient and deficient serum vitamin D level were observed in 43.9% (n=144) and 9.5% (n=31) of participants, respectively. Of the participants, 25.9% (n=85) had good glycemic control (<7.0%). Moderate and poor glycemic control were observed in 39.9% (n=131) and 34.1% (n=112) of the participants, respectively. A significant negative correlation (p<0.5) was found between vitamin D levels and kidney function test results (blood urea nitrogen and serum creatinine levels). An inverse relationship was observed between HbA1c levels and vitamin D deficiency. Conclusion Nephropathy is more likely to develop in people with type 2 diabetes mellitus and vitamin D deficiency.

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Vitamin D Combination of Osseous and Non-Osseous Benefits with Supplementation

Tladi¹,

Kgole²

2020

BJSTR

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A living tissue needs nutrients to survive and bone physiology should be balanced in order to be healthy. Vitamin D plays a critical role for both bones and other body tissue homeostasis. Various conditions have been found to be associated with low vitamin D and low levels of vitamin D in the bone can manifest from childhood. Other medical conditions (extra osseous) have also been found to be associated with low vitamin D. Currently the world is under attack from the Covid-19 pandemic, but reports indicate that we would benefit if the levels of vitamin D are optimum. Vitamin D enhances both the innate and cellular immunities that are crucial in fighting against the microorganisms that cause various infections. Studies report the prevention of respiratory tract infections if the levels of vitamin D in the body are optimal. Mechanisms of prevention include lower viral replication and reduction of an inflammatory process in the lungs. Various medical conditions can affect the bone directly or indirectly. Some literature studies have shown that there could be an association between low vitamin D and medical conditions, including orthopaedic conditions. Other secondary bone diseases can be prevented if the level of vitamin D is within normal range. We believe that giving patients vitamin D can reduce the cost of operations as well increase patients' lifespan. The aim of this review article is to outline the benefits of vitamin D for both osseous and non-osseous conditions and also to convey the importance of knowledge of vitamin D supplementation for an orthopaedic surgeon.

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Severe Vitamin D Deficiency in Saudi Patients with Type 2 Diabetes Mellitus

Cited by 3 publications

References 53 publications

Determinants of Vitamin D deficiency among type 2 diabetes mellitus patients: A retrospective study

Determinants of Vitamin D deficiency among type 2 diabetes mellitus patients: A retrospective study

Relationship of Vitamin-D Deficiency with Kidney Disease in Patients with Type-2 Diabetes Mellitus (T2DM) in the Makkah Region: A Cross-Sectional Study

Vitamin D Combination of Osseous and Non-Osseous Benefits with Supplementation

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