Vitamin D and C-Reactive Protein: A Mendelian Randomization Study

Liefaard, Marte C.; Ligthart, Symen; Vitezova, Anna; Hofman, Albert; Uitterlinden, André G.; Jong, Jessica C. Kiefte-de; Franco, Oscar H.; Zillikens, M. Carola; Dehghan, Abbas

doi:10.1371/journal.pone.0131740

Cited by 66 publications

(55 citation statements)

References 36 publications

(44 reference statements)

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“…The mechanism by which obesity reduces vitamin D sufficiency is thought to be related to sequestration of vitamin D in adipose tissue, producing a reduction in the bioavailability of its parent compound for subsequent metabolic activation . There is evidence that a low vitamin D level correlates with increased levels of inflammatory markers such as C reactive protein . Therefore, the present study is aligns with previous reports on the association between obesity and inflammation .…”

Section: Discussionsupporting

confidence: 90%

Serum level of 25‐hydroxyvitamin D and obesity among early pregnant women

Mahmoud

Saad

Mohieldein

et al. 2019

J of Obstet and Gynaecol

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Aim: To assess serum 25-hydroxyvitamin D 25(OH)D level in obese pregnant Sudanese women in early pregnancy. Methods: A match case-control study was conducted in Saad Abualila Hospital (Khartoum, Sudan). The cases were obese (body mass index [BMI] ≥ 30.0 kg/m 2 ) women. Controls were women with normal BMI (18.5-24.9 kg/m 2 ) matched for age, parity and gestational age. The 25(OH)D level was measured using ELISA.Results: There was no significant difference between the two groups in their age, parity or gestational age. There was no significant difference in the median (interquartile) level of the serum (25(OH)D between obese pregnant women and normal weight pregnant women (3.05 [11.100-15.937] ng/ml vs 13.05 [10.950-17.362] ng/ml, P = 0.237). There was no significant correlation between BMI and 25(OH)D level (r = −0.133, P = 0.149). Conclusion: There was no significant difference in the 25(OH)D level between the obese pregnant women and normal weight pregnant women in this study.

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Section: Discussionsupporting

confidence: 90%

Serum level of 25‐hydroxyvitamin D and obesity among early pregnant women

Mahmoud

Saad

Mohieldein

et al. 2019

J of Obstet and Gynaecol

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“…A recent study ( 36 ) , investigating the association between serum 25(OH)D and CRP and a potential causal effect by using genetic variants in bi-directional Mendelian randomisation analysis, in the Rotterdam Study, a prospective population-based cohort, showed that serum vitamin D was inversely associated with CRP. However, the results from the Mendelian randomisation analyses did not provide evidence for a causal association.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA)

et al. 2017

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Recent evidence suggests that low vitamin D concentrations are associated with increased levels of inflammatory markers. However, there are limited studies investigating associations between vitamin D levels and inflammatory markers in the general population and much of this evidence in older adults is inconclusive. Therefore, this study investigates the cross-sectional association of serum 25-hydroxyvitamin D (25(OH)D) levels with inflammatory markers in 5870 older English adults from wave 6 (2012–2013) of the English Longitudinal Study of Ageing (ELSA). ELSA is a large prospective observational study of community-dwelling people aged 50 years and over in England. Serum 25(OH)D levels, C-reactive protein (CRP) levels, plasma fibrinogen levels, white blood cell count (WBC), age, season of blood collection, waist circumference, total non-pension household wealth, measures of health and health behaviours that included depression, number of cardiovascular, non-cardiovascular conditions and difficulties in activities of daily living, smoking, and physical activity were measured. There was a significant negative association between low 25(OH)D levels (≤30 nmol/l) and CRP (OR 1·23, 95 % CI 1·00, 1·51) and WBC (OR 1·35, 95 % CI 1·13, 1·60) that remained after adjustment for a wide range of covariates of clinical significance. However, for fibrinogen, the association did not remain significant when waist circumference was entered in the final model. Our findings showed that 25(OH)D levels were associated with two out the three inflammatory markers investigated. The independent and inverse association between serum 25(OH)D levels and inflammation suggests a potential anti-inflammatory role for vitamin D in older English individuals from the general population.

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“…Observational studies have reported, though not consistently, associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concentrations [13,14,15]. Randomized controlled trials (RCT) [16,17,18,19,20,21,22] have produced inconsistent findings with respect to the effect of vitamin D supplementation regimens on serum CRP concentrations. A meta-analysis focusing on supplementation trials among overweight and obese individuals concluded the absence of a significant influence of vitamin D supplementation on serum CRP concentrations [23].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

et al. 2016

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The hypothesized effect of vitamin D on C-reactive protein (CRP) has received substantial attention as a potential means to alleviate the risk for cardiovascular disease. However, observational studies have been inconsistent in their reporting of associations between serum 25-hydroxyvitamin D (25(OH)D) and CRP concentrations, and trials and meta analyses have been inconsistent in their conclusions regarding the effect of vitamin D supplementation on CRP concentrations. These supplementation trials were mostly conducted among patients with more or less inflammatory complications and did not consider potential distinctive effects by weight status. To further our understanding of the potential influences of vitamin D on CRP, we analyzed longitudinal observations of 6755 participants of a preventative health program. On average, serum 25(OH)D concentrations increased from 88.3 to 121.0 nmol/L and those of CRP decreased from 1.7 to 1.6 mg/L between baseline and follow up. Relative to obese participants without temporal increases in 25(OH)D, those who showed improvements of <25, 25–50, 50–75, and more than 75 nmol/L at follow up were 0.57 (95% confidence interval: 0.37–0.88), 0.54 (0.34–0.85), 0.49 (0.30–0.80), and 0.48 (0.29–0.78) times as likely to have elevated CRP concentrations (≥1 mg/L), respectively. These associations were less pronounced and not statistically significant for normal weight and overweight participants. Herewith, the findings suggest that promotion of adequate serum 25(OH)D concentrations among obese individuals along with healthy lifestyles may alleviate the public health burden associated with cardiovascular disease.

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Vitamin D and C-Reactive Protein: A Mendelian Randomization Study

Cited by 66 publications

References 36 publications

Serum level of 25‐hydroxyvitamin D and obesity among early pregnant women

Serum level of 25‐hydroxyvitamin D and obesity among early pregnant women

Vitamin D and inflammatory markers: cross-sectional analyses using data from the English Longitudinal Study of Ageing (ELSA)

The Effect of Serum 25-Hydroxyvitamin D Concentrations on Elevated Serum C-Reactive Protein Concentrations in Normal Weight, Overweight and Obese Participants of a Preventive Health Program

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