Vitamin D and atopic dermatitis: A systematic review and meta-analysis

Kim, Ga Eun; Bae, Ji-Hyun

doi:10.1016/j.nut.2016.01.023

Cited by 58 publications

(52 citation statements)

References 35 publications

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“…The consistency of such a finding in a large number of studies [5][6][7][17][18][19][20][21][22], confirms that the low level of calcidiol in such a disease is not a coincidence, and that calcidiol deficiency has a possible role in the pathogenesis of AD. The controversy in the serum level of calcidiol in AD patients is mainly viewed among adult AD patients, where several studies showed the non-significant alteration of calcidiol levels among patient and control groups [8,9].…”

Section: Groupsupporting

confidence: 54%

“…Concerning its relation with AD, animal studies, case reports, and randomized clinical trials have suggested the role of calcidiol, through various mechanisms including immunomodulation [4]. Furthermore, an inverse relationship between the severity of AD and calcidiol levels has been previously suggested, and studies have shown that, in individuals with AD who are deficient in calcidiol, repletion of calcidiol results in improvement and decreased severity of the disease [5][6][7]; a notion that has been denied by others [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Despite the existence of numerous studies [5][6][7][8][9][10][11][12] tackling the connection that might exist between calcidiol and AD, the value of calcidiol in its treatment is far from clear. Adding to this, the proven existence of calcidiol receptor (VDR) polymorphism in the Egyptian population [13,14] gives more importance to studying the role of calcidiol and to assess its possible role in the treatment of AD in Egyptians; whether it is induced by phototherapy or given as an oral supplementation.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

Youssef¹,

Dorgham²,

Hegazy³

et al. 2017

J Clin Exp Dermatol Res

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Section: Groupsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

Youssef¹,

Dorgham²,

Hegazy³

et al. 2017

J Clin Exp Dermatol Res

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show abstract

“…Many clinical trials including their meta-analysis have shown that vitamin D supplementation results in significant improvement in AD severity (measured by SCORAD and Eczema Area and Severity Index) [121,135,136,137,138]. Di Filippo et al [138] suggested that vitamin D supplementation exerts its positive effect on AD by normalizing the altered Th1 and Th2 cytokines like IL-2, IL-4, IL-6, and IFN-γ in AD patients.…”

Section: Role Of Vitamin D In Certain Inflammatory Skin Diseasesmentioning

confidence: 99%

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

Umar

Sastry

Ali

et al. 2018

Skin Pharmacol Physiol

134

135

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Background: Vitamin D is a secosteroid, which was initially known for its skeletal role; however, in recent years, its functions in different organs have been increasingly recognized. In this review, we will provide an overview of vitamin D functions in the skin physiology with specific focus on its role in certain inflammatory skin conditions such as psoriasis and atopic dermatitis. Methods: A comprehensive literature search was carried out in PubMed and Google Scholar databases using keywords like “vitamin D,” “skin,” “atopic dermatitis,” and “psoriasis.” Only articles published in English and related to the study topic were included in this review. Results: Vitamin D is integrally connected to the skin for its synthesis, metabolism, and activity. It regulates many physiological processes in the skin ranging from cellular proliferation, differentiation, and apoptosis to barrier maintenance and immune functions. Vitamin D deficiency is associated with the risk of psoriasis and atopic dermatitis, and several clinical/observational studies have suggested the beneficial effect of vitamin D in the therapy of these 2 inflammatory skin disorders. Conclusions: Vitamin D exerts a pleiotropic effect in the skin and could be an important therapeutic option for psoriasis and atopic dermatitis.

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“…Another SR also evaluated vitamin D supplementation in adults and children with AE (9 RCTs, 576 participants). A meta‐analysis on four of these studies demonstrated that vitamin D supplementation resulted in a significant improvement in symptoms (mean difference 5.81, 95% CI −9.03 to −2.59, P = 0.0004).…”

Section: Complementary and Alternative Treatmentsmentioning

confidence: 99%

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention

et al. 2019

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Summary This review is part of a series of annual updates summarizing the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed during 2016 with a focus on treatment and prevention of AE. There is reasonable evidence of benefit for topical corticosteroids, calcineurin inhibitors, a glycyrrhetinic acid‐containing preparation (Atopiclair®), oral ciclosporin, oral azathioprine, narrowband ultraviolet B radiation and education programmes. Overall, there is evidence that topical corticosteroids and calcineurin inhibitors have similar efficacy and that both can prevent AE flares when used twice weekly as maintenance therapy. However, topical calcineurin inhibitors are costlier and have more adverse reactions, thus topical corticosteroids should remain the standard of care for patients with AE. There is no evidence that multiple applications are better than once‐daily application of topical corticosteroid. There is inconsistent evidence to support omalizumab and specific allergen immunotherapy use in AE. There is some evidence that vitamin D supplementation and synbiotics reduce AE severity, although the margin of improvement may not be clinically meaningful. There is little evidence to support the use of wet wraps or of complementary/alternative medicine (including Chinese herbal medicine). There is some evidence to suggest that a diet high in fish in infancy may be preventative for AE, but other dietary interventions for the prevention of AE show little promise. This review provides a succinct guide for clinicians and patients wishing to remain up to date with the latest evidence for the treatment and prevention of AE.

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Vitamin D and atopic dermatitis: A systematic review and meta-analysis

Cited by 58 publications

References 35 publications

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

Estimation of Calcidiol Level in Serum of Atopic Dermatitis Patients before and after NB-UVB Phototherapy in Comparison to Oral Vitamin D Therapy

Vitamin D and the Pathophysiology of Inflammatory Skin Diseases

What's new in atopic eczema? An analysis of systematic reviews published in 2016. Part 1: treatment and prevention

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