Vitamin D and anti-Müllerian hormone concentration in human follicular fluid individually aspirated from all patient follicles

Skowrońska, Patrycja; Kunicki, Michał; Pastuszek, Ewa; Konieczna, Lucyna; Bączek, Tomasz; Męczekalski, Błażej; Smolarczyk, Roman; Łukaszuk, Krzysztof

doi:10.1080/09513590.2021.1933934

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…However, AMH levels of follicle fluid do not depend on these developmental stages. There was a positive correlation between VitD and AMH levels of follicle fluid in this study [54]. By contrast, another study reported a negative association between AMH and VitD for VitD concentrations up to 30 ng/mL [55].…”

Section: 3contrasting

confidence: 79%

Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Fındık¹

2023

esmj

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Follikülogenez mekanizması çeşitli hormonları, büyüme faktörlerini ve sinyal moleküllerini içeren karmaşık bir süreçtir. Foliküler gelişim mekanizmaları üzerine gelecekteki araştırmalar, dişi reprodüktif yaşamı hakkında daha kapsamlı veriler sağlayacaktır. Vitamin D, steroidogenez yoluyla follikülogenezi etkiler. Granüloza hücrelerinde Vitamin D reseptör sinyali hormon salgılarını steroidojenik enzimler aracılığıyla düzenler. Vitamin D ve follikülogenez ile ilişkili mekanizma hala aydınlatılamamıştır. Follikülogenezin farklı evrelerinde yer alan çeşitli over kaynaklı otokrin-parakrin faktörler çalışmalarda gösterilmiştir. Bu faktörler yoluyla follikülogenez üzerindeki Vitamin D etkileri, altta yatan mekanizmayı anlamak için önemlidir. Sessiz primordial follikül aktivasyonunun inhibitörleri, Forkhead box O3a, anti-müllerian hormon, Fosfataz ve tensin homologu ve p27’dir. Bu faktörler arasından Forkhead box O3a, overde primordial folikül aktivite regülasyonu ve apoptoz mekanizmaları için önemli bir moleküldür. Primer follikülden preantral follikülün gelişiminde rol oynayan faktörler, dönüştürücü büyüme faktörü-β, büyüme ve farklılaşma faktörü 9, kemik morfogenetik protein 4,7,15 ve aktivindir. Bu derleme, steroidogenez ve ovaryan parakrin faktörler aracılığıyla VitD ve follikülogenez arasındaki ilişkiyi açıklamayı amaçlamaktadır

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Section: 3contrasting

confidence: 79%

Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Fındık¹

2023

esmj

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“…Certainly, there is a publication bias that promotes publications that assume such an association between vitamin D and human fertility. One recent study showed that vitamin D concentration in follicular fluid of infertility patients undergoing ovarian stimulation varies according to the developmental stage of the oocyte and was associated with embryo development status ( 36 ). A prospective cohort study included 150 infertile women who underwent IVF or ICSI found that women with higher levels of vitamin D in their serum and follicular fluid are significantly more likely to achieve pregnancy but without affecting the quality of embryo and fertilization rate ( 37 ).…”

Section: Discussionmentioning

confidence: 99%

25(OH)VitD and human endocrine and functional fertility parameters in women undergoing IVF/ICSI

Tian

Zeng²,

Cai

et al. 2022

Front. Endocrinol.

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BackgroundVitamin D plays an important role in reproduction. Evidence shown that free 25-hydroxyvitamin D (25(OH)VitD) was more accurate than total 25(OH)VitD in reflecting the status of 25(OH)VitD during pregnancy. However, the relationship between free 25(OH)VitD and female fertility parameters has not been reported yet. Therefore, this study aims to compare the correlation of free and total 25(OH)VitD with fertility parameters in infertility females undergoing in vitro fertilization and embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI).MethodsAccording to the inclusion and exclusion criteria, 2569 infertility patients who received IVF-ET or ICSI treatment for the first time participated in this study. Five milliliter peripheral blood samples of the patients were collected on the day before embryo transfer (ET). Enzyme linked immunosorbent assay (ELISA) kits was used to detect free 25(OH)VitD and total 25(OH)VitD, and clinical information was collected. Spearman’s rho was used to evaluate the association between the variables.ResultsThe median (IQR) of free 25(OH)VitD was 4.71 (4.11-5.31) pg/mL and total 25(OH)VitD was 19.54 (16.52-22.83) ng/m. The correlation between them, however, was week (rho=0.311). Compared to total 25(OH)VitD, free 25(OH)VitD was slightly better correlated with basal follicle-stimulating hormone (FSH) (rho=0.041, P=0.036), basal estradiol (E2) (rho=0.089, P<0.001), anti-Müllerian hormone (AMH) (rho=-0.057, P=0.004), antral follicle count (AFC) (rho=-0.053, P=0.007), E2 (rho=-0.080, P<0.001), number of oocytes retrieval (rho=-0.079, P<0.001) and progesterone (P)/E2 on hCG trigger day (rho=0.081, P<0.001).ConclusionsOverall, there was only a rather weak correlation of free as well as total 25(OH)VitD with human endocrine and functional fertility parameters in women undergoing IVF/ICSI. Neither free nor total 25(OH)VitD seems to play a major role in human embryo implantation.

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“…Several studies have been carried out to elucidate the role of VD in human reproduction, suggesting its relationship with spermatogenesis, ovarian reserve, follicular development, embryonic implantation, endometrial thickness, and its correlation with in vitro fertilization (IVF) ( Rehman et al ., 2021 ; Tian et al ., 2022 ; Hornstein, 2019 ; Neville et al ., 2016 ). In addition, other studies suggest that VD may influence the anti-Müllerian hormone (AMH) activity through its 25OH-D form, which would act on AMH type II receptors (AMHR-2) to inhibit the recruitment and maturation of follicles ( Hornstein, 2019 ; Muscogiuri et al ., 2017 ; Skowrońska et al ., 2022 ; Voulgaris et al ., 2017 ). Hypovitaminosis D is correlated with insulin resistance, polycystic ovary syndrome (PCOS) and endometriosis ( Tian et al ., 2022 ; Neville et al ., 2016 ; Dastorani et al ., 2018 ; Cunningham et al ., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and follicular recruitment in the in vitro fertilization cycle

Antunes,

Melo,

Souza

et al. 2024

JBRA

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Objective: Vitamin D (VD) is a fat-soluble steroid hormone, synthesized by the skin, most known for its role in bone mineral balance. Vitamin D receptors (VDR) are also found in the female reproductive system, but their role remains unclear. The objective of this study was to analyze the relationship between serum vitamin D levels and the number of oocytes retrieved after ovarian stimulation.Methods: This is a retrospective study involving 267 patients undergoing in vitro fertilization (IVF) carried out in the Fertipraxis clinic, a private practice facility. The patients were initially divided into two groups according to their VD levels. Group 1 included 152 patients with VD levels < 30 ng/mL and group 2 had 115 patients with VD levels > 30 ng/ mL. They were further analyzed and separated considering their age, anthropometric data, ovarian reserve, amount of gonadotropin used, and follicles obtained until trigger day.Results: In our analysis, there were no difference in the number of follicles and oocytes retrieved, nor in the number of mature oocytes obtained from patients with both vitamin D deficiency and sufficiency. Conclusions:The results of our study show no difference among number of follicles, oocytes retrieved and mature oocytes obtained after ovarian stimulation according to their vitamin D serum levels. Further higherquality studies are needed to evaluate the possible roles of serum vitamin D levels in other stages of human fertilization process.

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Vitamin D and anti-Müllerian hormone concentration in human follicular fluid individually aspirated from all patient follicles

Cited by 5 publications

References 32 publications

Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

25(OH)VitD and human endocrine and functional fertility parameters in women undergoing IVF/ICSI

Vitamin D and follicular recruitment in the in vitro fertilization cycle

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