Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Fındık, Damla Gül

doi:10.48176/esmj.2022.93

Cited by 2 publications

(2 citation statements)

References 49 publications

(69 reference statements)

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“…Several studies have reported disturbances in FSH and testosterone levels in infertile men [42,43]. Physiological studies have also identified the role of vitamin D as an important factor altering steroidogenesis (i.e., the production of hormones) [44,45]. Nevertheless, the contradictory reports on vitamin D's effects on sperm parameters and sex hormone levels in different studies indicate a collective gap in knowledge related to the exact mechanism of vitamin D's effects on human physiology.…”

Section: A a B Bmentioning

confidence: 99%

Impact of vitamin D supplementation as COVID-19 vaccine adjuvant on sperm parameters and sex hormones in men with idiopathic infertility: Two separate pre–post studies

Zarepoor,

Nazari,

Pourmasumi

2024

Clin Exp Reprod Med

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Objective: Vitamin D deficiency is a major problem for human health worldwide. The mechanisms of vitamin D in the male reproductive system are unknown. After coronavirus disease 2019 (COVID-19) vaccines were developed, doubts were raised about their possible effects on male fertility. Based on vitamin D’s function in the immune system, its potential role as an adjuvant for COVID-19 vaccines is intriguing. The aims of this study were to assess the effects of vitamin D first on sperm parameters and sex hormones, and then as an immune adjuvant on sperm parameters and sex hormones after study participants had received their second doses of COVID-19 vaccines.Methods: Phase 1 (before the COVID-19 pandemic) included 72 men with idiopathic infertility, and phase 2 had 64 participants who received two doses of COVID-19 vaccines. Both groups were instructed to take 50,000 IU of vitamin D twice monthly for 3 months. Sperm parameters and sex hormones were assessed pre- and post-supplementation.Results: Regular vitamin D intake for 3 months significantly increased the participants’ vitamin D levels (p=0.0001). Both phases showed a positive correlation between vitamin D intake and sperm parameters. Vaccination had no negative effects on sperm parameters and sex hormones. Vitamin D was associated with follicle-stimulating hormone (p=0.02) and testosterone (p=0.0001) in phase 2 after treatment. Conclusion: Our results support vitamin D supplementation as an immune adjunct to COVID-19 vaccination for improving sperm parameters and hormone levels. COVID-19 vaccination is not harmful for male fertility potential, and vitamin D is an effective factor for male fertility.

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Section: A a B Bmentioning

confidence: 99%

Impact of vitamin D supplementation as COVID-19 vaccine adjuvant on sperm parameters and sex hormones in men with idiopathic infertility: Two separate pre–post studies

Zarepoor,

Nazari,

Pourmasumi

2024

Clin Exp Reprod Med

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“…However, VitD3 and folliculogenesis-associated mechanism is still not elucidated. It requires comprehensive research regarding the mechanism of action on ovarian paracrine signals 12 . In the literature, it was reported that 600,000 IU VitD3 single-dose administration led to an increment of BMP15 and GDF9 levels in follicular fluid 13 .…”

Section: Introductionmentioning

confidence: 99%

Decreased growth differentiation factor 9, bone morphogenetic protein 15, and forkhead box O3a expressions in the ovary via ulipristal acetate

Fındık

Kaplanoğlu

Arık

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: Folliculogenesis is a complex process involving various ovarian paracrine factors. During folliculogenesis, vitamin D3 and progesterone are significant for the proper development of follicles. This study aimed to investigate the effects of vitamin D3 and selective progesterone receptor modulator ulipristal acetate on ovarian paracrine factors. METHODS: In the study, 18 female Wistar-albino rats were randomly divided into three groups: control group (saline administration, n=6), vitamin D3 group (300 ng/day vitamin D3 oral administration, n=6), and UPA group (3 mg/kg/day ulipristal acetate oral administration, n=6). Ovarian tissue was analyzed by histochemistry and immunohistochemistry. For quantification of immunohistochemistry, the mean intensities of growth differentiation factor 9, bone morphogenetic protein 15, and forkhead box O3a expressions were measured by Image J and MATLAB. Blood samples were collected for the analysis of serum anti-Müllerian hormone levels by ELISA. RESULTS: Atretic follicles and hemorrhagic cystic structures were observed in the UPA group. After immunohistochemistry via folliculogenesis assessment markers, growth differentiation factor 9, bone morphogenetic protein 15, and cytoplasmic forkhead box O3a expressions decreased in the UPA group (p<0.05). Anti-Müllerian hormone level did not differ significantly between the experimental groups (p>0.05). CONCLUSION: Ulipristal acetate negatively affects folliculogenesis via ovarian paracrine factors. The recommended dietary vitamin D3 supplementation in healthy cases did not cause a significant change.

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Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Cited by 2 publications

References 49 publications

Impact of vitamin D supplementation as COVID-19 vaccine adjuvant on sperm parameters and sex hormones in men with idiopathic infertility: Two separate pre–post studies

Impact of vitamin D supplementation as COVID-19 vaccine adjuvant on sperm parameters and sex hormones in men with idiopathic infertility: Two separate pre–post studies

Decreased growth differentiation factor 9, bone morphogenetic protein 15, and forkhead box O3a expressions in the ovary via ulipristal acetate

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