Vitamin D and Ageing: Neurological Issues

Annweiler, Cédric; Schott, Anne-Marie; Berrut, Gilles; Chauviré, Valérie; Gall, Didier Le; Inzitari, Marco; Beauchet, Olivier

doi:10.1159/000318570

Cited by 210 publications

(218 citation statements)

References 226 publications

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“…Various neuroprotective effects of vitamin D in the CNS and the eye may explain these associations. In vitro, vitamin D increases the synthesis of neurotrophic agents such as the Nerve Growth Factor (NGF) and the Glial cell lineDerived Neurotrophic Factor (GDNF), and regulates neuronal differentiation and maturation [26,27]. It also accelerates neuronal growth in a dose-dependent way in rat hippocampal cell cultures [28].…”

Section: Discussionmentioning

confidence: 99%

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

et al. 2015

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a b s t r a c tObjectives: Vitamin D is involved in visual health and function. Our objective was to determine whether age-related vitamin D insufficiency was associated with the presence and the severity of primary open angle glaucoma (POAG) in a case-control study of older adults. Study design: Case-control study.Main outcome measures. One hundred fifty cases diagnosed with moderate-to-severe POAG (mean, 75.1 ± 8.5 years; 42.0% female) and 164 healthy controls (mean, 73.0 ± 7.9 years; 59.8% female) were included. POAG diagnosis was based on classical diagnostic criteria of optic nerve cupping and/or RNFL thinning, measured with optical coherence tomography. Severe POAG was defined as Humphrey visual field mean deviation (MD) worse than −12 dB. Vitamin D insufficiency was defined as serum 25OHD ≤ 75 nmol/L. Age, gender, mean arterial pressure, vitamin D supplementation, visual acuity, and intraocular pressure were used as potential confounders. Results: POAG cases had lower mean serum 25OHD concentration than controls (42.9 ± 25.7 nmol/L versus 49.4 ± 29.5 nmol/L, P = 0.039) and a greater prevalence of vitamin D insufficiency (90.7% versus 82.3%, P = 0.032). Increased mean serum 25OHD concentrations were associated with lower POAG frequency, even after adjustment for potential confounders (OR = 0.89 per 10 nmol/L of 25OHD, P = 0.045). Similarly, vitamin D insufficiency was associated with POAG (OR = 2.09, P = 0.034). Among POAG cases, no 25OHD difference was observed between moderate and severe POAG cases (respectively, 39.2 ± 23.3 nmol/L versus 45.1 ± 26.7 nmol/L, P = 0.188); and no between-group difference regarding the prevalence of vitamin D insufficiency (88.9% versus 94.0%, P = 0.313). Conclusions: Decreased serum 25OHD concentration was associated with POAG. There was no 25OHD difference between moderate and severe POAG.

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Section: Discussionmentioning

confidence: 99%

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

et al. 2015

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“…Our results differ from 2 other published systematic reviews of vitamin D and cognitive performance. 10,11 Barnard and Colon-Emeric 11 suggested that cognitive function measured by MMSE was not associated with 25(OH)D concentration although their conclusions were based on whether the relationship between vitamin D and cognitive test scores in the original studies was statistically significant. Since statistical significance depends on sample size, solely focusing on this criterion could mask a small consistent effect in underpowered studies.…”

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confidence: 99%

“…9 Two recent systematic reviews examined the association between vitamin D and cognitive performance, 10,11 but found insufficient evidence to make a conclusion. Both studies were limited in their scope of study inclusion, and provided no meta-analysis.…”

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Vitamin D, cognition, and dementia

Balion

Griffith²,

Strifler³

et al. 2012

Neurology

400

345

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Objective: To examine the association between cognitive function and dementia with vitamin D concentration in adults.Methods: Five databases were searched for English-language studies up to August 2010, and included all study designs with a comparative group. Cognitive function or impairment was defined by tests of global or domain-specific cognitive performance and dementia was diagnosed according to recognized criteria. A vitamin D measurement was required. Two authors independently extracted data and assessed study quality using predefined criteria. The Q statistic and I 2 methods were used to test for heterogeneity. We conducted meta-analyses using random effects models for the weighted mean difference (WMD) and Hedge's g. Results:Thirty-seven studies were included; 8 contained data allowing mean Mini-Mental State

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“…there is loss of buffering ability, and wide excursions of pressure and heart rate) leading to an inappropriate adaptive response to standing up. 26 Vitamin D metabolites regulate the genetic expression of neurotrophins (nerve growth factor and neurotransmitters) with a consequent reduction in appropriate compensatory mechanisms during standing up. 27,28 Third, another explanation relies on the fact that hypovitaminosis D could be involved in increasing blood pressure levels which may result in the prescription of antihypertensive drugs and consequent greater risk of iatrogenic OH.…”

Section: Discussionmentioning

confidence: 99%

Hypovitaminosis D predicts the onset of orthostatic hypotension in older adults

Veronese

Trevisan

Bolzetta

et al. 2016

Journal of the American Society of Hypertension

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A number of small cross sectional studies have demonstrated that hypovitaminosis D (represented by low 25 hydroxyvitamin D (25OHD) levels) is associated with orthostatic hypotension (OH). We investigated if hypovitaminosis D is associated with the onset of OH in older adults over a followup of 4.4 years. 25OHD was categorized using sex specific quartiles; OH was defined as a drop of ≤20 mm Hg in systolic or ≤10 mm Hg in diastolic blood pressure <3 minutes of standing. Among 1,308 elderly without OH at baseline, using an adjusted logistic regression analysis and taking those with higher baseline serum 25OHD as reference, there was a significant increase in the onset of OH in those with lower serum 25OHD levels. The association was significant only in women when we stratified by sex. In conclusion, hypovitaminosis D predicts the onset of OH in older adults, particularly in women.

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Vitamin D and Ageing: Neurological Issues

Cited by 210 publications

References 226 publications

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

Serum vitamin D status is associated with the presence but not the severity of primary open angle glaucoma

Vitamin D, cognition, and dementia

Hypovitaminosis D predicts the onset of orthostatic hypotension in older adults

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