Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats

Hajiluian, Ghazaleh; Nameni, Ghazaleh; Shahabi, Parviz; Mesgari‐Abbasi, Mehran; Sadigh-Eteghad, Saeed; Farhangi, Mahdieh Abbasalizad

doi:10.1038/ijo.2017.10

Cited by 59 publications

(34 citation statements)

References 45 publications

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“…Unlike to the metabolic improvements, Vit D had no significant change in cognitive function. This finding is consistent with the previous studies in ovariectomized [ 46 ], aged [ 47 ] and Alzheimer model of rats [ 48 ] but in contradictory with some other studies on Alzheimer [ 49 ], obese [ 50 ] and ovariectomized rats [ 51 ]. It should be noticed that the dose and duration of Vit D supplementation in our study were sufficient, because serum concentration of Vit D was significantly correlated with supplementation.…”

Section: Discussionsupporting

confidence: 92%

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Babaei

Shirkouhi

Hoseini

et al. 2017

Diabetol Metab Syndr

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PurposeHere, we studied the beneficial effects of aerobic exercise on metabolic syndrome components, cognitive performance, brain derived neurotrophic factor (BDNF) and irisin in ovariectomized rats with different serum vitamin D (Vit D) status.MethodsEighty female wistar rats were divided into 2 groups of sham operated (sham, n = 8), and ovariectomized (OVX, n = 72). Then OVX were divided into 9 groups of receiving combination of exercise protocol with low dose of Vit D (OVX + EXE + LD), high dose of Vit D (OVX + EXE + HD), Vit D deficiency (OVX + EXE − D), and (OVX + EXE + Veh). Also non exercised groups of OVX receiving high dose of Vit D (OVX + HD), low dose of Vit D (OVX + LD), Vit D deficiency (OVX − D), and Veh (OVX + Veh) were included. After 2 months of related interventions, spatial memory was assessed using Morris water maze (MWM), and then metabolic syndrome components were measured.ResultsHigh dose of Vit D supplementation showed significant reduction in weight (p = 0.001), lipid profiles (p = 0.001), visceral fat (p = 0.001) and waist circumference (p = 0.001) regardless of exercising or not, with no change in cognitiive function. Serum BDNF level was significantly higher in Vit D deficient group (p = 0.001), and was decreased in the OVX + HD. In contrary, irisin did not show any significant relationship with serum concentration of Vit D, while it was significantly elevated in the exercised groups compared with non-exercised counterparts.ConclusionVit D insufficiency deteriorates metabolic syndrome components, and elevates serum BDNF as a compensatory metabotropic factor, and further supplementation significantly attenuates these components parallel with reduction in BDNF. In addition, aerobic exercise successfully induces various metabolic benefits, provided optimum serum level of Vit D.

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Section: Discussionsupporting

confidence: 92%

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Babaei

Shirkouhi

Hoseini

et al. 2017

Diabetol Metab Syndr

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“…BDNF deficiency has been associated with age-dependent impairment in spatial learning [ 40 ], neurodegeneration [ 41 ], and cognitive dysfunction [ 42 ], as well as with depression [ 43 , 44 , 45 ]. Vitamin D supplementation may increase BDNF concentration in the hippocampus [ 46 ]—A critical brain region for emotion regulation. Neural stem cells treated with vitamin D have shown increased expression of BDNF [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

Serum 25-Hydroxyvitamin D Concentrations Are Associated with Mental Health and Psychosocial Stress in Young Adults

et al. 2020

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We aimed to test the hypothesis that serum 25-hydroxyvitamin D3 (25(OH)D) concentration is associated with mental health and life stress measures in young adults and investigate gender and racial disparities in these associations. This study comprised 327 black and white participants. Depression, trait anxiety, perceived stress, and hostility were measured by the following validated instruments: Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS), and Cook–Medley Hostility Scale (CMHS). Linear regression was used to estimate correlations between serum 25(OH)D concentration and mental health measurements in the total population and in subgroups stratified by gender and race. In this sample (28.2 ± 3.1 years, 52% female, 53% black), serum 25(OH)D concentration was negatively related to BDI, STAI, PSS, total CMHS score, and the majority of CMHS subscale scores (p-values < 0.05). Stratified by gender, most of these associations remained significant only in women (p-values < 0.05). Stratified by race, higher 25(OH)D concentrations in white participants were significantly related to lower BDI, STAI, PSS, and CMHS-cynicism subscales (p-values < 0.05); 25(OH)D concentrations in the black participants were only inversely associated with CMHS and most CMHS subscales (p-values < 0.05) but not with BDI, STAI, and PSS. We present novel findings of consistent inverse relationships between serum 25(OH)D concentration and various measures of mental health and life stress. Long-term interventional studies are warranted in order to investigate the roles of vitamin D supplementation in the prevention and mitigation of depression, anxiety, and psychological stress in young adults.

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“…As such, there is a need for randomized clinical trials on vitamin D treatment in patients at risk of neurodegenerative disorders so as to optimize knowledge and precision on the efficiency of vitamin D congeners, appropriate dosing, and correct biochemical and clinical monitoring. A proper endocrine approach would suggest the use of vitamin D congeners related to optimal drug delivery through the brain blood barrier [ 265 ], using gradually increasing doses to avoid the risk of falls in frail populations [ 266 ]. In view of the advantage that vitamin D supplementation is readily available and affordable, there is a need for further research in this field.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Neurological Diseases: An Endocrine View

Somma

Scarano

Barrea³

et al. 2017

IJMS

179

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Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the “non-calcemic” actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer. In parallel, growing evidence has recognized that a multimodal association links vitamin D system to brain development, functions and diseases. With vitamin D deficiency reaching epidemic proportions worldwide, there is now concern that optimal levels of vitamin D in the bloodstream are also necessary to preserve the neurological development and protect the adult brain. The aim of this review is to highlight the relationship between vitamin D and neurological diseases.

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Vitamin D administration, cognitive function, BBB permeability and neuroinflammatory factors in high-fat diet-induced obese rats

Abstract: Vitamin D reversed HFD-induced cognitive impairments by reduction of the NF-κB and elevation of BDNF concentrations and modulation of the BBB permeability in rats' hippocampus.

Cited by 59 publications

References 45 publications

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Vitamin D is associated with metabotropic but not neurotrophic effects of exercise in ovariectomized rats

Serum 25-Hydroxyvitamin D Concentrations Are Associated with Mental Health and Psychosocial Stress in Young Adults

Vitamin D and Neurological Diseases: An Endocrine View

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