Vitamin D Actions on Cell Differentiation, Proliferation and Inflammation

Almeida, Lucas Ferreira de; Coimbra, Terezila Machado

doi:10.15406/ijcam.2017.06.00201

Cited by 6 publications

(4 citation statements)

References 22 publications

(21 reference statements)

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“…Many genes are regulated by the active form of vitamin D (1,25dihydroxyvitamin D) in tissues such as the immune system, bone, muscles, lungs, heart, and kidney, among others. Although its primary biological action, which is mediated by vitamin D receptor (VDR), is to regulate serum calcium levels and promote bone mineralization, several studies have described vitamin D as a potent non-proliferation, pro-differentiation and immunomodulation factor [1]. Its precursor, 25-hydroxyvitamin D (25(OH)D) is the circulating form of vitamin D which is considered the best marker to assess vitamin D levels [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women

et al. 2018

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“…The vitamin D receptor (through which calcitriol achieves its functions) was believed to be exclusively endocrine, coupling with retinoic X receptor to form a heterodimer, subsequently binding to response elements in the promoter regions of target genes and exerting effects related to mineral metabolism (24). Recent research has shown that the vitamin D receptor is expressed in tissues of multiple origin which could explain its varying effects such as immunomodulation, cell proliferation and differentiation (25,26). Further, a cytoplasmic form of the vitamin D receptor has been identified that responds rapidly or non-genomically to calcitriol and is thought to be involved in cellular calcium handling and other processes (24,27).…”

Section: Discussionmentioning

confidence: 99%

Does serum Vitamin D affect lipid profile?

2021

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Introduction and Aim: Vitamin D, besides its classical physiological functions, exerts effects on brain, prostate, breast, colon, pancreas, and immune cells due to the ubiquitous presence of its receptors. Hypovitaminosis D predisposes individuals to various micro and macro vascular complications of metabolic syndrome and diabetes mellitus. Despite speculations regarding implications of its deficiency on the cardio metabolic health of general/ susceptible population, its role remains underexplored in the Indian population. Materials and Methods: This cross-sectional study carried out in Biochemistry Department of the institution, recruited 219 patients (after obtaining written consent) of both genders above18 years who underwent Vitamin D testing. Blood samples obtained were assayed for HbA1c, C Reactive protein, thiol and lipid. Kruskal Wallis test and Spearman correlation were employed for statistical analysis. Results: Significantly low HDL and high atherogenic index of plasma (AIP) were observed in males with vitamin D deficiency. Significant inverse correlation of vitamin D with CRP and total cholesterol (among vitamin D deficient males) was observed. A significant inverse correlation between serum HDL and AIP and a significant direct correlation between triglyceride and AIP were observed irrespective of their vitamin D status. Heat map showed marginally elevated lipid parameters among vitamin D insufficient males. Conclusion: Vitamin D may emerge as a surrogate marker in risk stratification of patients with diabetes and dyslipidaemia. More insights are required to assess the gender specific susceptibility to dyslipidaemia and atherosclerosis in relation to vitamin D levels.

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“…Vitamin D is now being known for its potential antiproliferative, pro-differentiation and immunomodulatory roles. It can regulate cell differentiation and growth by binding to the VDF's that are found in most body cells [10].…”

Section: Regulation Of Cell Differentiation and Growthmentioning

confidence: 99%

Vitamin D in Health and Disease

2019

ARC Journal of Nutrition and Growth

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Vitamin D is one of the most essential micronutrient required by our body. It is aptly called the sunshine vitamin, as it is majorly synthesized by the ultraviolet B (UVB) light obtained from the sun, which is then converted into its active form in the liver and kidneys. Studies found that vitamin D plays a vital part not only in bone health, but also in non-skeletal functions such as regulation of gene expression and enhancing the immune system. However, the key issue is inadequate amount of vitamin D in our body, due to low dietary intake and limited sunlight exposure. Vitamin D deficiency poses a significant public health problem due to its association with osteoporosis, osteomalacia, fractures, risk of cancer, diabetes, heart disease and other chronic illnesses. It is necessary for all individuals of any age group to consume the recommended amounts of vitamin D. some measures to replenish its deficiency is sunlight exposure, food fortification and routine supplementation. This review article emphasizes the role of vitamin D in the body, prevalence of vitamin D deficiency, potential implications along with strategies for treatment and prevention of its deficiency.

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Vitamin D Actions on Cell Differentiation, Proliferation and Inflammation

Cited by 6 publications

References 22 publications

Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women

Vitamin D levels in Mediterranean breast cancer patients compared with those in healthy women

Does serum Vitamin D affect lipid profile?

Vitamin D in Health and Disease

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