Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure

Li, Yan Chun; Qiao, Guilin; Uskoković, Milan R.; Xiang, Wei; Zheng, Wei; Kong, Juan

doi:10.1016/j.jsbmb.2004.03.004

Cited by 499 publications

(398 citation statements)

References 52 publications

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“…First, in experimental studies, 1,25-dihydroxyvitamin D regulates the renin-angiotensin-aldosterone system via suppression of renin gene expression (28,29) and has vasculoprotective effects that inhibits vascular smooth muscle cell proliferation (30) and vascular calcification. (31) Second, vitamin D 3 supplementation ($2000 IU/d) was found to improve endothelial function in a trial among African American individuals compared to placebo.…”

Section: Discussionmentioning

confidence: 99%

Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity

Bischoff‐Ferrari

Dawson‐Hughes

Stöcklin³

et al. 2011

Journal of Bone and Mineral Research

161

172

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To test the effect of 25(OH)D 3 (HyD) compared to vitamin D 3 on serum 25-hydroxyvitamin D levels (25(OH)D), lower extremity function, blood pressure, and markers of innate immunity. Twenty healthy postmenopausal women with an average 25(OH)D level of 13.2 AE 3.9 ng/mL (mean AE SD) and a mean age of 61.5 AE 7.2 years were randomized to either 20 mg of HyD or 20 mg (800 IU) of vitamin D 3 per day in a double-blind manner. We measured on 14 visits over 4 months, 25(OH)D serum levels, blood pressure, and seven markers of innate immunity (eotaxin, interleukin [IL]-8, IL-12, interferon gamma-induced protein 10 kDa , monocyte chemotactic protein-1 [MCP-1], macrophage inflammatory protein beta , and ''Regulated upon Activation, Normal T-cell Expressed, and Secreted'' [RANTES]). At baseline and at 4 months, a test battery for lower extremity function (knee extensor and flexor strength, timed up and go, repeated sit-to-stand) was assessed. All analyses were adjusted for baseline measurement, age, and body mass index. Mean 25(OH)D levels increased to 69.5 ng/mL in the HyD group. This rise was immediate and sustained. Mean 25(OH)D levels increased to 31.0 ng/mL with a slow increase in the vitamin D 3 group. Women on HyD compared with vitamin D 3 had a 2.8-fold increased odds of maintained or improved lower extremity function (odds ratio [OR] ¼ 2.79; 95% confidence interval [CI], 1.18-6.58), and a 5.7-mmHg decrease in systolic blood pressure ( p ¼ 0.0002). Both types of vitamin D contributed to a decrease in five out of seven markers of innate immunity, significantly more pronounced with HyD for eotaxin, IL-12, MCP-1, and MIP-1 b. There were no cases of hypercalcemia at any time point. Twenty micrograms (20 mg) of HyD per day resulted in a safe, immediate, and sustained increase in 25(OH)D serum levels in all participants, which may explain its significant benefit on lower extremity function, systolic blood pressure, and innate immune response compared with vitamin D 3 . ß

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Section: Discussionmentioning

confidence: 99%

Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity

Bischoff‐Ferrari

Dawson‐Hughes

Stöcklin³

et al. 2011

Journal of Bone and Mineral Research

161

172

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“…Vitamin D has been shown to suppress renin-angiotensin-aldosterone system by inactivating renin gene expression and inhibiting renin synthesis. 39 Other antihypertensive effects of vitamin D include renoprotective effects, vasodilatatory and antiatherosclerotic properties, and effects on calcium homeostasis including prevention of secondary hyperparathyroidism. 18,40,41 In contrast, PTH has been shown to stimulate renin release by activation of the renin-angiotensinaldosterone system.…”

Section: -O76mentioning

confidence: 99%

Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men

Chan

Woo

et al. 2011

J Hum Hypertens

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Vitamin D status, parathyroid hormone (PTH) level and their associations with blood pressure in Chinese population are unknown. This study examined these associations in older Chinese men. Blood pressure, serum 25-hydroxyvitamin D (25OHD) and PTH was measured in 939 community-dwelling Chinese men aged 65 years and older. Linear regression analyses were performed with adjustments for age, body mass index, education, season of measurement, medication use, self-reported history of stroke and Parkinson's disease, and other lifestyle factors. In either crude or adjusted models, serum 25OHD was not associated with blood pressure, whereas increasing PTH levels was associated with higher blood pressure. Men in the highest quartile of serum PTH level had a mean difference of 3.4 mm Hg and 2.8 mm Hg higher in as systolic blood pressure (SBP) and diastolic blood pressure (DBP), respectively, than men in the lowest quartile of serum PTH level (P trend ¼ 0.019 for SBP and o0.001 for DBP). In conclusion, the findings support an association between serum PTH and blood pressure, but not for serum 25OHD in older Chinese men whose vitamin D status is optimal. The lack of association between serum 25OHD and blood pressure may possibly because of the relatively high serum 25OHD levels of the study sample.

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“…Vitamin D may help to protect against cognitive deterioration and dementia, specifically, vascular dementia and Alzheimer's disease, through vasculoprotection (Lind, Wengle et al 1987;Burgess, Hawkins et al 1990;O'Connell, Berry et al 1997;Pfeifer, Begerow et al 2001;Wang, Wu et al 2001;Zittermann, Schleithoff et al 2003;, preservation of neurons (Sutherland, Somerville et al 1992;Landfield and Cadwallader-Neal 1998;Brewer, Thibault et al 2001), and protection against risk factors for cognitive dysfunction (Lind, Wengle et al 1987;Burgess, Hawkins et al 1990;Hypponen, Laara et al 2001;Pfeifer, Begerow et al 2001;Li, Kong et al 2002;Zittermann, Schleithoff et al 2003;Bischoff-Ferrari, Dietrich et al 2004;Li, Qiao et al 2004;.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

305

219

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Vitamin D: a negative endocrine regulator of the renin–angiotensin system and blood pressure

Cited by 499 publications

References 52 publications

Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity

Oral supplementation with 25(OH)D3 versus vitamin D3: Effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity

Serum 25-hydroxyvitamin D and parathyroid hormone levels in relation to blood pressure in a cross-sectional study in older Chinese men

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

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