Vitamin D: a negative acute phase reactant

Waldron, Jenna L; Ashby, Helen; Cornes, Michael; Bechervaise, Julia; Razavi, Cyrus; Thomas, Osmond; Chugh, Sanjiv; Deshpande, Shreeram; Ford, Clare; Gama, Rousseau

doi:10.1136/jclinpath-2012-201301

Cited by 233 publications

(225 citation statements)

References 13 publications

Supporting

Mentioning

212

Contrasting

Unclassified

Order By: Relevance

“…24,30,31 The observation of an acute decline from baseline in serum 25(OH)D drawn 48 hours after surgery has even led to the suggestion that serum 25(OH)D is a negative acute-phase reactant. 32 The current study furthers the skepticism about the therapeutic role for nutritional vitamin D in reducing inflammation by showing no effect of increasing serum 25 (OH)D on epoetin responsiveness or hsCRP levels.…”

Section: Discussionmentioning

confidence: 53%

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Miskulin

Majchrzak²,

Tighiouart

et al. 2015

JASN

View full text Add to dashboard Cite

Locally produced 1,25-dihydroxyvitamin D3 may have pleiotropic effects outside of bone. Experimental and observational studies suggest that nutritional vitamin D may enhance erythropoiesis in settings of 25-hydroxy vitamin D (25(OH)D) deficiency. We conducted a double-blind, placebo-controlled, randomized clinical trial to assess the effects of supplementation with ergocalciferol on epoetin utilization and other secondary outcomes in patients on hemodialysis with serum 25(OH)D ,30 ng/ml. In all, 276 patients were randomized to 6 months of ergocalciferol or placebo. Mean6SD serum 25(OH)D increased from 16.065.9 ng/ml at baseline to 39.2614.9 ng/ml in the ergocalciferol arm and did not change (16.966.4 ng/ml and 17.567.4 ng/ml, respectively) in the placebo arm. There was no significant change in epoetin dose over 6 months in the ergocalciferol or placebo arms (geometric mean rate 0.98 [95% confidence interval (95% CI), 0.94 to 1.02] versus 0.99 [95% CI, 0.95 to 1.03], respectively) and no difference across arms (P=0.78). No change occurred in serum calcium, phosphorus, intact parathyroid hormone, or C-reactive protein levels, cinacalcet use, or phosphate binder or calcitriol dose in either study arm. Rates of all-cause, cardiovascular, and infection-related hospitalizations did not differ by study arm, although statistical power was limited for these outcomes. In conclusion, 6 months of supplementation with ergocalciferol increased serum 25(OH)D levels in patients on hemodialysis with vitamin D insufficiency or deficiency, but had no effect on epoetin utilization or secondary biochemical and clinical outcomes.

show abstract

Section: Discussionmentioning

confidence: 53%

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Miskulin

Majchrzak²,

Tighiouart

et al. 2015

JASN

View full text Add to dashboard Cite

show abstract

“…Moreover, despite convincing in vitro findings, there are examples of observational studies finding no associations (6), and clinical trials and reviews have been inconclusive about the role of vitamin D (7,8). These inconsistent findings have led to a discussion on whether hypovitaminosis D is a cause or a consequence of inflammation (9,10). There is also no consensus on the definition of optimal vitamin D status (11).…”

mentioning

confidence: 99%

Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia

et al. 2017

View full text Add to dashboard Cite

BACKGROUND: There is no consensus on optimal Vitamin D status. The objective of this study was to estimate the extent to which vitamin D status predicts illness duration and treatment failure in children with severe pneumonia by using different cutoffs for vitamin D concentration. METHODS:We measured the plasma concentration of 25(OH)D in 568 children hospitalized with World Health Organization-defined severe pneumonia. The associations between vitamin D status, using the most frequently used cutoffs for vitamin D insufficiency (25(OH)Do50 and o75 nmol/l), and risk for treatment failure and time until recovery were analyzed in multiple logistic regression and Cox proportional hazards models, respectively. RESULTS: Of the 568 children, 322 (56.7%) had plasma 25(OH) D levels ≥ 75 nmol/l, 179 (31.5%) had levels of 50-74.9 nmol/l, and 67 (%) had levels o50 nmol/l. Plasma 25(OH)D o50 nmol/l was associated with increased risk for treatment failure and longer time until recovery. CONCLUSION: Our findings indicate that low vitamin D status (25(OH)Do50 nmol/l) is an independent risk factor for treatment failure and delayed recovery from severe lower respiratory infections in children.

show abstract

“…[9] Interestingly, serum 25(OH)D shows an inverse relationship with C-reactive protein, although the significance of this relationship is not completely understood. [12,24] As a cross sectional analysis, this study has several inherent limitations. First, we are unable to assess specific trends in serum 25(OH)D. Therefore, perioperative and long term outcomes associated with specific serum 25(OH) D are not revealed.…”

Section: Discussionmentioning

confidence: 99%

“…[9,12] One study reported 77.7% of hip fracture patients had sub-normal serum 25(OH)D versus 58.6% in normal controls. [17] Furthermore, periprosthetic joint infections (PJI) show a close association with vitamin D deficiency in the arthroplasty population.…”

Section: Discussionmentioning

confidence: 99%

“…[6,11] The high prevalence of vitamin D deficiency in those undergoing orthopedic surgery is well described. [12] However, limited studies exist documenting vitamin D deficiency in the elective arthroplasty group, particularly in a subtropical climate. The goal of our study is to explore the prevalence and distribution of vitamin D deficiency among an elective total joint arthroplasty (TJA) population within a lower latitude climate with relatively abundant sunshine.…”

Section: Hydroxy Vitamin D [25(oh)d] [3]mentioning

confidence: 99%

See 1 more Smart Citation

Exploration of Serum 25-Hydroxy Vitamin D in Total Joint Arthroplasty within a Subtropical Climate

Naylor

King²,

Voges³

et al. 2017

ReconRev

View full text Add to dashboard Cite

Background: The importance of appropriate serum 25-hydroxy vitamin D [25(OH)D] for multiple health measures is widely described, however, the prevalence of vitamin D deficiency remains remarkably high. The goal of our study is to explore the distribution of vitamin D deficiency among an elective total joint arthroplasty (TJA) population within a lower latitude climate with relatively abundant sunshine. We hypothesize this group will demonstrate a high prevalence of vitamin D deficiency, thus exposing a potential opportunity to improve outcomes with proper identification and management.Methods: From January to December, 2014, serum 25(OH)D levels were collected during a standard preoperative workup prior to primary or revision joint arthroplasty in South Carolina. Mean serum 25(OH)D, seasonal variation, and patient demographics were recorded. We defined Vitamin D deficiency consistent with the current Endocrine Society classification: serum 25(OH)D < 20 ng/ml, 21-29 ng/ml, and 30-100 ng/ml representing deficiency, insufficiency, and normal, respectively.Results: A total of 308 patients underwent evaluation. 46.8% (144) of the participants were female, and 89.6% (276) identified as Caucasian. The mean patient age was 68.3 years ±13.8 (32-88

show abstract

Vitamin D: a negative acute phase reactant

Cited by 233 publications

References 13 publications

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Ergocalciferol Supplementation in Hemodialysis Patients With Vitamin D Deficiency: A Randomized Clinical Trial

Vitamin D status is associated with treatment failure and duration of illness in Nepalese children with severe pneumonia

Exploration of Serum 25-Hydroxy Vitamin D in Total Joint Arthroplasty within a Subtropical Climate

Contact Info

Product

Resources

About