Vitamin D: A cheap yet effective bullet against coronavirus disease-19 - Are we convinced yet?

Sharma, Suresh K; Mudgal, Shiv Kumar; Pai, Venkatesh S; Chaturvedi, Jitender; Gaur, Rakhi

doi:10.5455/njppp.2020.10.05132202024052020

Cited by 4 publications

(5 citation statements)

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“…Vitamin D supplementation also reduced rotavirus replication in pigs ( 154 ). A recent review article by Sharma et al, summarized biological plausibility arguments and found that vitamin D deficiency is associated with a wide range of viral illnesses, and that vitamin D supplementation was both preventative and decreased severity, limiting hyper-inflammatory complications ( 107 ).…”

Section: Results Of Searchesmentioning

confidence: 99%

“…Sharma et al, reviewed the literature informing decisions about COVID-19 and vitamin D 3 , finding compelling evidence for 10,000 IU/day for a month, followed by 5,000 IU/day to bring 25(OH)D levels up to the target of 40-60 ng/ml, then recommended a more modest 1000-2,000 IU/day (107). One group, Quesada-Gomez et al, posited that vitamin D supplementation should be with oral calcifediol (108).…”

Section: Controversy Over Recommended Supplement Dosesmentioning

confidence: 99%

“…Additional authors recommend vitamin D supplements to boost the immune systems of patients diagnosed with COVID-19 (2 p , 35, 69, 71, 74, 75, 118, 120, 125, 230-233). However, most authors recommend widespread daily vitamin D supplementation (most often with 1,000-5,000 IU per day) to prevent and decrease the severity of COVID-19, at least until the pandemic abates (1,5,12,28,34,36,42,64,65,107,109,113,114,116,121,124,127,165,171,172,178,190,192,197,198,210,214,219,222,(234)(235)(236)(237)(238)(239)(240)(241)(242)(243)(244)(245)(246)(247)(248) (Figure 8).…”

Section: Covid-19-specific Recommendations Of Expertsmentioning

confidence: 99%

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A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency

Benskin

2020

Front. Public Health

130

135

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As the world's attention has been riveted upon the growing COVID-19 pandemic, many researchers have written brief reports supporting the hypothesis that vitamin D deficiency is related to the incidence and severity of COVID-19. The clear common thread among the top risk groups-vitamin D deficiency-may be being overlooked because of previous overstated claims of vitamin D benefits. However, the need to decrease COVID-19 fatalities among high-risk populations is urgent. Early researchers reported three striking patterns. Firstly, the innate immune system is impaired by vitamin D deficiency, which would predispose sufferers to viral infections such as COVID-19. Vitamin D deficiency also increases the activity of the X-chromosome-linked "Renin-Angiotensin" System, making vitamin D deficient individuals (especially men) more susceptible to COVID-19's deadly "cytokine storm" (dramatic immune system overreaction). Secondly, the groups who are at highest risk for severe COVID-19 match those who are at highest risk for severe vitamin D deficiency. This includes the elderly, men, ethnic groups whose skin is naturally rich in melanin (if living outside the tropics), those who avoid sun exposure for cultural and health reasons, those who live in institutions, the obese, and/or those who suffer with hypertension, cardiovascular disease, or diabetes. And thirdly, the pattern of geographical spread of COVID-19 reflects higher population vitamin D deficiency. Both within the USA and throughout the world, COVID-19 fatality rates parallel vitamin D deficiency rates. A literature search was performed on PubMed, Google Scholar, and RSMLDS, with targeted Google searches providing additional sources. Although randomized controlled trial results may be available eventually, the correlational and causal study evidence supporting a link between vitamin D deficiency and COVID-19 risks is already so strong that it supports action. The 141 author groups writing primarily about biological plausibility detailed how vitamin D deficiency can explain every risk factor and every complication of COVID-19, but agreed that other factors are undoubtedly at work. COVID-19 was compared with dengue fever, for which oral vitamin D supplements of 4,000 IU for 10 days were significantly more effective than 1,000 IU in reducing virus replication and controlling the "cytokine storm" (dramatic immune system over-reaction) responsible for fatalities. Among the 47 original research studies summarized here, chart reviews found that serum vitamin D levels predicted COVID-19 mortality Benskin Evidence Linking Vitamin D, COVID-19 rates (16 studies) and linearly predicted COVID-19 illness severity (8 studies). Two causal modeling studies and several analyses of variance strongly supported the hypothesis that vitamin D deficiency is a causal, rather than a bystander, factor in COVID-19 outcomes. Three of the four studies whose findings opposed the hypothesis relied upon disproven assumptions. The literature review also found that prophylactically correcting possible ...

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Section: Results Of Searchesmentioning

confidence: 99%

Section: Controversy Over Recommended Supplement Dosesmentioning

confidence: 99%

Section: Covid-19-specific Recommendations Of Expertsmentioning

confidence: 99%

See 1 more Smart Citation

A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency

Benskin

2020

Front. Public Health

130

135

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“…As a part of preparedness of the health care workers, it is similarly evident that vitamin D supplementation may be suggested with a low dose of 1000-2000IU to help sustain the serum level. 16 Government agencies have invested a huge fund and resources to train and educate HCPs, so that they can be prepared to manage COVID-19 pandemic. Study findings reveled that there was a difference in HCPs' preparedness based on the different level of institutes.…”

Section: Discussionmentioning

confidence: 99%

Healthcare Professionals’ Preparedness for COVID-19 Pandemic: A Cross-Sectional Survey in Northern India

Sharma

Mudgal

Priya

2022

Natl J Community Med

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Background: Health care agencies have framed guidelines for healthcare professionals (HCPs) to manage COVID-19 pandemic but still there is paucity of Indian data on HCPs preparedness. Aim: To assess level of perceived preparedness of healthcare professionals against COVID-19. Method: This cross-sectional study included 1218 HCPs (nurses, physicians and technicians) from government and private institutes through convenience sampling technique. Online survey was done to assess preparedness of HCPs against COVID-19, using self-structured questionnaire based on HCPs preparedness checklists released by WHO and CDC. Results: Only 42.4% HCPs considered themselves prepared for donning and doffing of PPE and around 65.8% were confident in providing direct patient care. Gender had significant difference (P<0.001) on level of perceived preparedness of HCPs. Younger participants shown higher level of preparedness than older participants (P=0.022). Technicians were less prepared with significantly low mean scores 10.36±2.55 than nurses (11.45±2.45) and physicians (11.68±2.17; p=.038). HCPs working in tertiary level institutes had significantly higher mean preparedness scores (11.86±2.89; P<.001) than those working in primary (10.49±2.68) and secondary level institutes (10.57±2.35). Conclusion: All HCPs should be strongly encouraged for regular participation in training and simulation exercises arranged by institute as continuing education, which may enhance their preparedness against COVID-19 pandemic.

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“…As this disease spreading very firstly so that every person should know about COVID19 prevention or breaking down the transmission. 7,8 This pandemic situation of COVID-19 has necessitated the need to make the people aware about this to encourage them to practice the precautionary measures in order to have a control over the situation. This highlights the need to assess the knowledge of the people regarding COVID-19 in order to get information about people's cognitions and ideology.…”

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confidence: 99%

Are people having adequate knowledge to prevent COVID-19 pandemic? A cross-sectional study

Kaur

Sharma

Deepika

et al. 2021

Int J Community Med Public Health

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Background: The Covid-19 pandemic is still going on around the globe and prevention of this pandemic is depend on how much people are aware regarding COVID-19 disease. The present study was conducted with an aim to determine the level of knowledge towards COVID-19 among people.Methods: Present study included cross sectional descriptive survey design which was conducted on 366 participants who visited in university during 2020. Convenient sampling technique was chosen for selection of samples. A self-structured knowledge questionnaire was used for data collection. Descriptive and inferential statistics were used to analyse the data in SPSS.Results: Study findings revealed that there were 343 (93.7%) female participants and were students (86.3%). Overall, more than half (60.1%) of participants had good knowledge while 37.2% had average knowledge on COVID-19. Significant difference was found among participants’ group (p>0.001), gender (p=0.021), education (p=0.002), marital status (p=0.002), age (p=0.021), and inhabitants (p=0.002 Participants showed poor knowledge on COVID-19 susceptibility (81%) and diagnosis (90%) aspects.Conclusions: Study concluded that many people were still had average and poor knowledge on COVID-19. Higher authorities must find the ways for making people more aware on this pandemic to control its impact.

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Vitamin D: A cheap yet effective bullet against coronavirus disease-19 - Are we convinced yet?

Cited by 4 publications

References 0 publications

A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency

A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency

Healthcare Professionals’ Preparedness for COVID-19 Pandemic: A Cross-Sectional Survey in Northern India

Are people having adequate knowledge to prevent COVID-19 pandemic? A cross-sectional study

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