Vitamin C

Yussif, Nermin

doi:10.5772/intechopen.81783

Cited by 10 publications

(11 citation statements)

References 134 publications

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“…The easily oxidized quality of AA makes it a good antioxidant within cells because it is capable of neutralizing free radicals. However, that same feature makes it unstable and easily broken down 4,5 . Possible strategies to improve stability are exclusion of oxygen during formulation and opaque packaging as well as a formulation that exhibits low pH, minimal water, encapsulation, and the addition of other antioxidants and/or electrolytes 6 …”

Section: L‐ascorbic Acidmentioning

confidence: 99%

A review of topical vitamin C derivatives and their efficacy

Enescu

Bedford

Potts

et al. 2021

J of Cosmetic Dermatology

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Vitamin C is a popular ingredient in over‐the‐counter cosmeceuticals due to its many biological functions in maintaining and improving skin health by treating UV damage, improving discoloration, and boosting collagen production. Several chemically modified derivatives of vitamin C have been developed in an attempt to increase the stability, percutaneous absorption, and overall activity of this ingredient in topical formulations. The goal of this review is to evaluate the differences between vitamin C derivatives that have been designed for cosmeceutical use and their efficacy.

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Section: L‐ascorbic Acidmentioning

confidence: 99%

A review of topical vitamin C derivatives and their efficacy

Enescu

Bedford

Potts

et al. 2021

J of Cosmetic Dermatology

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“…Its activity in enzyme oxidation, immune function, and oxidative stress is often reported in the literature [ 37 ]. Even though it is a water-soluble vitamin, it helps vitamin E, a fat-soluble vitamin, through the regeneration of the active form, α-tocopherol [ 38 ], [ 39 ]. Vit.…”

Section: Introductionmentioning

confidence: 99%

“…Vit. C is also required in the production of collagen, melanine, and carnitine [ 37 , 39 ]. Unlike most animals, humans lost the capacity to synthesize it endogenously [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, vit. C deficiency has been called scurvy [ 39 ]. Scurvy manifestations include irritability, vascular fragility as a consequence of low collagen levels, dermatologic symptoms as gingival swelling, loss of the teeth, ecchymosis, infections, and extreme pain [ 39 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

“…C deficiency has been called scurvy [ 39 ]. Scurvy manifestations include irritability, vascular fragility as a consequence of low collagen levels, dermatologic symptoms as gingival swelling, loss of the teeth, ecchymosis, infections, and extreme pain [ 39 , 41 ]. Interestingly, scurvy was also found to be linked with ASD in numerous case reports [ 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

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Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

et al. 2020

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Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides on childhood can lead to Autism spectrum disorder (ASD) occurrence. The aim of this study was to evaluate the potential protective role of vitamin C (Vit. C) from children’s supplements after 14 days chronic exposure to insecticide mixture fipronil (Fip) + pyriproxyfen (Pyr) on juvenile zebrafish for swimming performances, social behavior and oxidative stress associated with ASD model. Juvenile (14–17 mm) wild-type AB zebrafish (Danio rerio) (45 days) were exposed to relevant concentrations: vit. C (25 µg L−1), Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1/1.89 μM), and [Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1 /1.89 μM)] + vit. C (25 µg L−1). Our results showed that insecticides can disturb the social behavior of zebrafish during 14 days of the administration, decreased the swimming performances, and elevated the oxidative stress biomarkers of SOD (superoxide dismutase), GPx (glutathione peroxidase), and MDA (malondialdehyde). The vitamin C supplement significantly attenuated the neurotoxicity of insecticide mixture and oxidative stress. This study provides possible in vivo evidence to show that vitamin C supplements could attenuate oxidative stress and brain damage of fipronil and pyriproxyfen insecticide chronic exposure on zebrafish juvenile.

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Technological Processing of Dried Powdered Rosehips to Tablets Through Wet Granulation

Špaglová,

Matušková,

Lawson

et al. 2023

European Pharmaceutical Journal

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The pseudo-fruits of Dog Rose are a rich source of L-ascorbic acid and several other active substances, which means their high supportive therapeutic potential. The study aimed to examine the impact of the chosen technological procedure for the preparation of tablets containing rosehip powder on the amount of L-ascorbic acid in the final pharmaceutical form. Drying of the plant drug was performed at room temperature to avoid possible thermal degradation of this heat-sensitive compound. Similarly, drying of the granules after wet granulation in the oven was replaced by natural drying at room temperature. The composition of two types of prepared granule formulations differed in the filler – lactose (LAC) or microcrystalline cellulose (MCC). Apart from the disintegration test, they meet the technological requirements for granules or tablets. Lactose was confirmed as a more suitable filler, which despite the unsuccessful disintegration of the granules, ensures the disintegration of tablets within 15 minutes even without the addition of a special excipient acting as a disintegrant. The content of L-ascorbic acid detected using isotachophoresis – capillary zone electrophoresis was 87.16 ± 5.06 µg in LAC tablets and 63.33 ± 2.83 µg in MCC tablets.

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Vitamin C

Cited by 10 publications

References 134 publications

A review of topical vitamin C derivatives and their efficacy

A review of topical vitamin C derivatives and their efficacy

Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

Technological Processing of Dried Powdered Rosehips to Tablets Through Wet Granulation

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