Vitamin C modulates lead excretion in rats

Lihm, Ho-Seob; Kim, Hyun; Chang, Hee-Kyung; Yoon, Myunghee; Lee, Kayoung; Choi, Jong-Soon

doi:10.5115/acb.2013.46.4.239

Cited by 20 publications

(5 citation statements)

References 16 publications

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“…The Zn–AA complexes accumulated in the in vitro situation, while these complexes may be eliminated from the lung in the in vivo situation. Metal chelate complexes are known to be mobilized into urine or feces by chelating agents in vivo (Andersen, 1989; Lihm et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

et al. 2017

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Exposure to zinc oxide nanoparticles (ZnO NPs) promotes acute pulmonary toxicity through oxidative stress and inflammation. Furthermore, dissolved zinc from ZnO NPs induces the formation of intracellular reactive oxygen species (ROS). We previously reported that supplemental ascorbic acid (AA) inhibits ZnO NP-induced acute pulmonary toxicity in a rat model; however, the mechanism of this action remains unclear. Therefore, we investigated the effects of AA on ZnO NP-induced cytotoxicity in human lung carcinoma A549 cells. AA was found to suppress intracellular production of ROS, and thus reduce the subsequent inflammation of ZnO NPs. However, intracellular Zn concentrations were higher in AA-treated cells than in AA-untreated cells. AA was found to react with Zn but not with the ZnO NPs themselves. These results suggest the possibility that AA-chelated extracellular Zn and the Zn-AA complex was readily taken up into cell. Even if the intracellular Zn level was high, cytotoxicity might be reduced because the Zn-AA complex was stable. Co-treatment of AA to A549 inhibited ROS production and subsequent intracellular inflammatory responses. These results are consistent with those previously reported from an in vivo model. Thus, two possibilities can be considered about the cytotoxicity-reducing the effect of AA: antioxidant efficacy and chelating effect.

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Section: Discussionmentioning

confidence: 99%

Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

et al. 2017

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“…The possible route of HgCl 2 elimination could be through urine and feces ( Manahan, 2003 ). However, the mechanism of toxicity of Hg is still unveiled ( Manahan, 2003 ), where most of them are speculative ( Lihm et al., 2013 , Wang et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Interactive effect of dietary vitamin E and inorganic mercury on growth performance and bioaccumulation of mercury in juvenile olive flounder, Paralichthys olivaceus treated with mercuric chloride

Moniruzzaman

Lee

et al. 2017

Animal Nutrition

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A 6-week feeding trial was carried out to evaluate the effects of dietary vitamin E (dl-α-tocopheryl acetate, TA) on growth and mercury (Hg) accumulation in juvenile olive flounder (Paralichthys olivaceus) treated with mercuric chloride (HgCl2). Vitamin E and HgCl2 were added to the semi-purified basal diet. Six semi-purified diets in a 2 × 3 factorial design were formulated to contain 2 levels of Hg (0 or 20 mg HgCl2/kg diet) and 3 levels of vitamin E (0, 100, or 200 mg TA/kg diet). Experimental fish (n = 360, 9.99 ± 0.15 g) were randomly allocated into 30-L tanks at a density of 20 fish per tank with 3 replicates in each treatment and were fed twice a day. At the end of the feeding trial, dietary Hg depressed the growth performances in terms of weight gain (WG), specific growth rate (SGR), feed efficiency (FE) and protein efficiency ratio (PER) in fish, while fish fed the diets supplemented with vitamin E showed significant growth improvement in both presence and absence of HgCl2 in the diets (P < 0.05). Survival rate was not affected in fish fed the experimental diets. Whole body compositions of fish such as lipid and moisture contents were influenced by dietary vitamin E supplementation. Total Hg contents of muscle, liver and kidney tissues were significantly reduced in fish fed diets supplemented with vitamin E (P < 0.05), while the two-way ANOVA showed that increasing Hg concentration has resulted in a reduction in vitamin E. Whole body fatty acids of fish like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) contents were decreased by dietary Hg. However, supplementation of dietary vitamin E improved the α-linolenic acid (ALA) and EPA contents in fish. Our results suggest that dietary supplementation of vitamin E has potential effects on growth improvement and ameliorating inorganic Hg bioaccumulation in juvenile olive flounder.

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“…Toraman et al 23 No cytotoxic effect was observed in studies using vitamin C at higher doses than the dose used in our study. 34,35 In addition, in our previous studies, the dose used in this study was applied to rats without any side effects. 22,23 Oxidative stress contributes to impaired cellular differentiation function, which stimulates osteoclast differentiation 10 and the overproduction of proinflammatory cytokines such as IL-1, IL-6, and TNF-α 36 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of Effects of Local Vitamin C Application on Inflammatory Response and Periodontal Tissue Destruction in Rat Periodontitis Model

AYTEKİN,

TORAMAN,

KARAÇAM

2023

Selcuk Dental Journal

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Background: The present study aims to evaluate the effect of local vitamin C application on inflammatory response and periodontal tissue destruction in rats with experimental periodontitis. Methods: A total of 21 animals, 7 rats in each group, were used in the study: 1- Non-ligation (NL), 2-experimental periodontitis (EP), and 3- local vitamin C (VtC) groups. Experimental periodontitis was induced in EP and VtC group rats. After 11 days, the ligature was removed. 50 mL of saline solution and vitamin C were injected locally into the vestibule sulcus of the EP and VtC group rats, respectively. After the rats were sacrificed, blood and gingival tissue samples were taken. TNF-α levels were analyzed biochemically in serum and 8-OHdG and MMP-8 were analyzed immunohistochemically in gingival tissue. The mandibular specimens were histologically evaluated for bone destruction and attachment loss. Results: The numeric density of 8-OHdG and MMP-8 immunopositive cells were found to be statistically significantly lower in the Vtc group than in the EP group. Vitamin C administration significantly reduced attachment loss and bone loss in the VtC group as compared to the EP group. However, there was no significant difference in serum TNF-α level in the VtC group compared to the EP group. Conclusions: Local application of vitamin C may reduce inflammation-related bone destruction by supporting the inflammatory response with the antioxidant activity of vitamin C and contributing to the resolution of inflammation with its potential immunomodulatory effect. Vitamin C may be a therapeutic agent that can be used in the treatment of periodontitis.

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Vitamin C modulates lead excretion in rats

Cited by 20 publications

References 16 publications

Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

Ascorbic acid prevents zinc oxide nanoparticle–induced intracellular oxidative stress and inflammatory responses

Interactive effect of dietary vitamin E and inorganic mercury on growth performance and bioaccumulation of mercury in juvenile olive flounder, Paralichthys olivaceus treated with mercuric chloride

Investigation of Effects of Local Vitamin C Application on Inflammatory Response and Periodontal Tissue Destruction in Rat Periodontitis Model

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