Vitamin C levels in patients with familial adenomatous polyposis

Abstract

Incidence of dysplasia in anorectal mucosa: A. Tsunoda et al. AcknowledgementsOur thanks to Miss Jill Grimsey for typing the manuscript Parks AG, Nicholls RJ. Proctocolectomy without ileostomy for ulcerative colitis. Br Med J 1978; ii: 85-8. Johnston D, Holdsworth DJ, Nasmyth DG ef al. Preservation of the entire anal canal in conservation proctocolectomy for ulcerative colitis: a pilot study comparing end-to-end ileo-anal anastomosis without mucosal resection with mucosal proctectomy and endo-anal anastomosis. Br J Surg 1987; 74: 9404. Parks AG, Nicholls RJ, Belliveau P. Proctocolectomy with ileal reservoir and anal anastomosis. Br J Surg 1980; 57: 533-8. Riddell RH, Goldman H, Ransohoff DH et al. Dysplasia in inflammatory bowel disease: standardised classification with provisional clinical applications. Hum. Patho/. 1983; 14: 93146. 3. 4. Short note 5. 6. Morson BC. The polyp-cancer sequence in the large bowel. Proc. Roy. Soc. Med. 1974; 67: 451-7. Neal DE, Williams NS, Johnston D. Rectal, bladder and sexual function after mucosal proctectomy with and without a pelvic ileal reservoir for colitis and polyposis. Br J Surg 1982; 69: 7. Nicholls RJ, Belliveau P, Neil1 M e f al. Restorative proctocolectomy with ileal reservoir: a pathophysiological assessment. Gut 1981; 22: 462-8. Keighley MRB. Abdominal mucosectomy reduces the incidence ofsoiling and sphincter damage after restorative proctocolectomy and J-pouch. Dis Colon Rectum 1987; 30: 38690. Stern H, Cohen Z . Personal communication. Martin LW, Torres AM, Fischer JE et a/. The critical level for preservation of continence in the ileo-anal anastomosis. J Pediarr. Surg. 1985; 20: 6647.

Expression of heavy subunit of γ‐glutamylcysteine synthetase (γ‐GCSh) in human colorectal carcinoma

“…25 (v) In familial adenomatous polyposis (FAP) patients, an increase in the free radical generating enzyme xanthine oxidase 26 and a decrease in antioxidant capacity was found. 27 Moreover, Bras et al 28 reported that prooxidant status (lipid peroxidation) is statistically increased was higher and antioxidant status (ascorbate and catalase activities ) was reduced. (vi) Polyak et al 29 found that 7 out of 10 human colorectal cancer cell lines contain DNA mutation in mitochondria, an organelle generates ROS.…”