Serum nutrients and habitual dietary intake in colectomized FAP patients in Norway

Almendingen, Kari; O, Fausa; Høstmark, Arne T.; Bratlie, Jorunn; Mørkerid, Lars; Aabakken, Lars; Vatn, Morten H.

doi:10.1007/s00394-008-0772-1

Cited by 7 publications

(10 citation statements)

References 29 publications

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“…The intake of omega-3 fatty acids was lower than the minimum recommendation of 0.5% of energy in the patients not taking omega-3 supplements [41, 42]. Notably, cancer patients are generally advised to take supplements with very long chain omega-3 fatty acids, and to follow the general dietary guidelines [43].…”

Section: Discussionmentioning

confidence: 99%

Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

et al. 2010

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Familial adenomatous polyposis (FAP) provides a model for sporadic colorectal cancer development. Cyclooxygenase (COX) inhibition may ameliorate polyp development, but rofecoxib was withdrawn due to cardiovascular side effects. Although this selective COX-2 inhibitor, like diet, may alter the fatty acid and eicosanoid pattern, data on the potential alteration in tissues after use, are scarce. The aims were to study if rofecoxib might influence the fatty acid distribution in serum phospholipids and duodenal lesions, mRNA for COX-1 and COX-2 in leucocytes and duodenal lesions, and finally plasma levels of PGE2 in a randomized, double-blind, placebo controlled study (n = 38). Significant reductions were found for essential fatty acid index both in serum phospholipids (P = 0.01, 95% CI = −0.9; −0.1), and in duodenal lesions (P = 0.04, 95 CI % = −0.9; −0.1) after treatment. No treatment effects were found on the COX mRNA expression, or in the plasma PGE2 levels. Dietary AA/EPA ratio was inversely associated with all the indicators of EFA status (all P < 0.01). These findings suggest that the effects of COX chemoprevention should be further investigated in FAP and that dietary needs should be included in the treatment of FAP.

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Section: Discussionmentioning

confidence: 99%

Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

et al. 2010

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“…The main dietary-source of arachidonic acid is animal products. However, the dietary assessment showed that the intake of such foods was normal among these familial adenomatous polyposis patients [18]. …”

Section: Discussionmentioning

confidence: 99%

“…In the ileostomy group, levels of total cholesterol were negatively correlated to the content of palmitic acid, palmitolic acid, stearic acid, oleic acid, linoleic acid, and monounsaturated fatty acids (<18 C atoms) in feces, which is interesting since the present levels of total cholesterol are lower than those among a healthy reference group [18]. In the ileal-pouch-anal anastomosis group separately, the content of monounsaturated fatty acid in feces was positively correlated to dietary intake of monounsaturated fatty acids in particular.…”

Section: Discussionmentioning

confidence: 99%

“…Data from the present study are taken from a randomized double-blind placebo-controlled intervention study with a cyclooxygenase-2 inhibitor [12, 14, 18]. The main aim was to compare the effect of Rofecoxib treatment on duodenal lesions (data in preparation).…”

Section: Methodsmentioning

confidence: 99%

“…Questions were related to habitual frequency of consumption and the amount of foods eaten during the last year. They were asked to identify their habitual choices of edible fats by pointing at specially prepared pictures, in order to increase the validity of the estimate of dietary fat [18]. …”

Section: Methodsmentioning

confidence: 99%

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Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients

Almendingen

Høstmark²,

Larsen³

et al. 2010

Journal of Nutrition and Metabolism

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A few familial adenomatous polyposis studies have focused upon faecal sterols and bile acids but none has analysed the fecal content of fatty acids. We report here findings of an observational study on 29 colectomized familial adenomatous polyposis patients that describe the fecal content of fatty acids, and relate this to the proportions of fatty acids and levels of cyclooxygenase mRNA expression in duodenal biopsies, levels of serum lipoproteins, and diet. In the ileostomy group separately (n = 12), the fecal content of arachidonic acid was correlated negatively to the proportions of eicosapentaenoic acid and docosahexaenoic acid in duodenal biopsies. Total serum-cholesterol was negatively correlated to the fecal content of saturates and monounsaturates. The fecal palmitoleic acid/palmitic acid ratio was positively correlated to the levels of cyclooxygease-2 expression in duodenal biopsies.In the ileal-pouch-anal anastomosis group separately (n = 17), significant correlations were found between the fecal contents of oleic acid, linoleic acid, and alpha-linolenic acid, and the proportions of myristic acid, oleic acid and eicosaenoic acid in duodenal biopsies. Dietary monounsaturates were positively correlated to different fecal fatty acids. Future studies should focus on molecular mechanisms relevant to fatty acid metabolism, inflammation, and angiogenesis, in addition to nutrition.

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Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas

Yao

Suo

Andersson

et al. 2017

Cochrane Database of Systematic Reviews

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Serum nutrients and habitual dietary intake in colectomized FAP patients in Norway

Abstract: We would suggest that the nutrient intake among FAP patients should at least meet the recommendations for healthy subjects. Their risk of metachronous cancers should also cause special attention to dietary factors that may prevent nutritional deficiency and carcinogenesis.

Cited by 7 publications

References 29 publications

Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP

Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients

Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas

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