Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas

Yao, Yibo; Suo, Tao; Andersson, Roland; Cao, Yongqing; Wang, Chen; Lu, Jin-Gen; Chui, Evelyne

doi:10.1002/14651858.cd003430.pub2

Cited by 50 publications

(68 citation statements)

References 113 publications

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“…Second, some challenged Burkitt's enthusiasm for fibre by pointing to confounding variables such as healthy lifestyle factors including reduced smoking, greater exercise and consumption of nonfibre nutrients found in fruit and vegetables . Third, there were exaggerated expectations for the therapeutic potential of fibre in reversing gastrointestinal pathology . The potential for fibre to prevent rather than treat infectious, diverticular and neoplastic disorders would have been a more realistic objective.…”

Section: Challenges and Disappointmentsmentioning

confidence: 99%

“…However, much of the available prospective data have demonstrated an inverse relationship between fibre intake and incident colorectal cancer risk . The previous discrepancies are likely explained by a lack of evidence for fibre in reducing the risk of recurrent adenomatous colorectal polyps . Proposed mechanisms for a protective fibre effect on colorectal cancer risk include dilution of faecal carcinogens, quicker gut transit times, SCFA production and binding of carcinogenic bile acids .…”

Section: Challenges and Disappointmentsmentioning

confidence: 99%

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Review article: dietary fibre in the era of microbiome science

O’Grady

O’Connor

Shanahan

2019

Aliment Pharmacol Ther

116

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Background: Explanations for the health benefits of dietary fibre have, in the past, been inconsistent and studies of the physiological effects of dietary fibre were, perhaps, directed at the wrong read-outs. Confounding factors included a failure to appreciate the molecular diversity and varied properties of fibre-types and the role of fibre as a substrate for microbial metabolism in the gut. Aim:To present a modern perspective on fibre science and to encourage clinicians to re-consider the health impact of dietary fibre and how best to approach adjustments in dietary consumption.Methods: This perspective is drawn selectively from recent microbiome science; no attempt was made to perform an exhaustive review of all articles related to every aspect of dietary fibre. Results: Advances in microbiome science have revealed not only the functional impact of dietary fibre on the composition and function of the microbiota but have also demonstrated the physiologic responses to microbial-derived metabolites from fibre digestion. Moreover, studies have shown the personalised nature of host responses to dietary fibre intervention, with outcomes being dependent on individual pre-treatment gut ecology. Conclusions: The physical properties of dietary fibres are important for homeostasis within the gut, but the predominant health benefits extend beyond the gut to enhanced metabolic welfare, including protection against obesity and related metabolic diseases. Fibre is a form of functional food joining a growing list of examples of diet-microbe-host interactions which link microbe-host metabolic and immune cascades.

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Section: Challenges and Disappointmentsmentioning

confidence: 99%

Section: Challenges and Disappointmentsmentioning

confidence: 99%

Review article: dietary fibre in the era of microbiome science

O’Grady

O’Connor

Shanahan

2019

Aliment Pharmacol Ther

116

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“…Although the precise effects of diets on oncogenesis have not been completely elucidated, microbiome changes and chronic inflammation are believed to contribute to the development of CRC. Whereas experimental evidence supports the hypothesis that dietary fiber maybe protective against CRC development, epidemiologic data remains inconclusive . Preventative measures, including dietary and lifestyle changes, are an attractive strategy to reduce the incidence of CRC.…”

Section: Introductionmentioning

confidence: 99%

Sodium Butyrate Inhibits Colorectal Cancer Cell Migration by Downregulating Bmi‐1 Through Enhanced miR‐200c Expression

Tao

Chen

et al. 2018

Molecular Nutrition Food Res

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“…Butyrate has been reported as a chemo-preventive agent [39,40]. However, a Cochrane review of randomized controlled trials found no statistically significant effect of dietary fiber intervention versus placebo or normal diet on the recurrence of colorectal adenomas [41]. Further research is therefore needed to investigate the potential benefits of fiber for CRC prevention.…”

Section: Discussionmentioning

confidence: 99%

Hospital-Based Preliminary Observations of Dietary Intake and Physical Activity in Saudi Patients with Colorectal Polyps: A Call for Nutrition Care Integration after Polypectomy Procedure

Alkhaldy

2020

Gastrointestinal Disorders

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Aim: In Saudi Arabia, the incidence of colorectal cancer (CRC) is increasing. Lifestyle modification, including diet and physical activity, is as important as the standard procedure of colonoscopy screening in reducing CRC development. I explored the dietary intake, physical activity, and selected nutritional biomarkers in Saudi patients with colorectal polyps, a precursor of CRC. Methods: Thirty polypectomy patients (aged 35–84 years) were recruited from an endoscopy unit at King Abdulaziz University Hospital. Demographic, anthropometric, physical activity, and food frequency data were collected. Plasma C-reactive protein, serum 25-hydroxy vitamin D, and folate levels were measured. Results: The median body mass index (BMI) of the patients was within the overweight cut-off range. The median consumption of carbohydrate and protein was within the recommended dietary allowance (RDA). Median fat consumption was above the RDA, while median fiber intake was below the RDA. Patients met the recommended servings/day of fruits, vegetables, dairy products, and protein but exceeded the recommended intake of fats and sweets. Most patients were non-active, with an inadequate level of serum vitamin D. Conclusion: We observed several risk factors previously associated with CRC, including low levels of physical activity, serum vitamin D, and fiber intake, and high BMI and fat intake among polypectomy patients.

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Dietary fibre for the prevention of recurrent colorectal adenomas and carcinomas

Abstract: Trusted evidence. Informed decisions. Better health.

Cited by 50 publications

References 113 publications

Review article: dietary fibre in the era of microbiome science

Review article: dietary fibre in the era of microbiome science

Sodium Butyrate Inhibits Colorectal Cancer Cell Migration by Downregulating Bmi‐1 Through Enhanced miR‐200c Expression

Hospital-Based Preliminary Observations of Dietary Intake and Physical Activity in Saudi Patients with Colorectal Polyps: A Call for Nutrition Care Integration after Polypectomy Procedure

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