Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats

Owu, Daniel U.; Antai, A. B.; Udofia, K. H.; Obembe, A; Obasi, K. O.; Eteng, MU

doi:10.1007/bf02708409

Cited by 57 publications

(44 citation statements)

References 24 publications

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“…The rise in BMR is attributed to increased breakdown of lipids and proteins, as lipids have a higher concentration of energy than do carbohydrates. Therefore in their breakdown, BMR is raised (Owu et al, 2006). The present study shows that oral administration of aqueous leaf extract of R. longiflora reduced BMR in diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Leaf Extract Of Rothmannia Longiflora Improves Basal Metabolic Rate And Electrolyte Parameters In Alloxan Induced Diabetic Rats

Ikpi

Obembe²,

Nku³

2009

Nig. J. Phys Sci

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Summary: This study evaluated the action of aqueous leaf extract of Rothmannia longiflora on basal metabolic rate and electrolyte profile of alloxan-induced diabetic rats. Fifteen male Wistar (135 -140g) were assigned to 3 groups of 5 rats each. Group 1 which served as control received placebo treatment; Group 2 -the diabetic (untreated) group also received placebo treatment whereas Group 3 -the extract treated diabetic group was administered the extract (15g/kg body weight) by oral administration for 14 days. Results of BMR measurement showed a significant increase (P<0.01) in BMR level of Diabetic untreated group (1.03±0.02ml/hr/g) when compared to the Control group (0.79±0.07ml/hr/g). Extract treatment significantly decreased (P<0.05) BMR in the diabetic rats. Results of analyses of serum electrolytes and glucose showed significant decreases (P<0.01) in sodium and chloride concentrations in the diabetic untreated group when compared to the control. However, sodium and chloride concentrations in the extract treated diabetic were not significantly different from those of their control values. There was no significant difference in potassium and urea concentrations in the extract-treated diabetic rats with respect to their control values. Extract treatment significantly reduced (P<0.05) serum glucose level of the extract treated group when compared to the diabetic untreated group. This suggests that oral administration of Rothmannia longiflora might be beneficial for the restoration of basal metabolic rate and the improvement of electrolyte profile in diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Aqueous Leaf Extract Of Rothmannia Longiflora Improves Basal Metabolic Rate And Electrolyte Parameters In Alloxan Induced Diabetic Rats

Ikpi

Obembe²,

Nku³

2009

Nig. J. Phys Sci

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“…[1] Diabetes mellitus is a multifactorial disease characterized by hyperglycemia, [2,3] lipoprotein abnormalities, [4] raised basal metabolic rate, [5] defect in reactive oxygen species scavenging enzymes [6] and high oxidative stress induced by the generation of highly reactive free radicals which are also involved in pancreatic destruction. [2,7] Insufficient removal of these free radicals can lead to oxidative damage to membranes; enhance susceptibility to lipid peroxidation, enzyme inactivation and nucleic acid damage.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of Oxidative Damage in Alloxan Induced Diabetic Rabbits Following Administration of the Extract of the Leaves of Vernonia amygdalina.

Owolabi

Jaja

Olatunji

et al. 2011

Free Radicals and Antioxidants

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Introduction: Diabetes is a disease that constitutes multiple sources of free radicals, thus oxidative stress is expected to have a double impact. Since oxidative stress is mediated by hyperglycemia-induced generation of free radical, it is supposed that compounds with hypoglycemic and antioxidative properties would be useful antidiabetic agents. Our study investigated the use of V. amygdalina as a potential hypoglycemic and antioxidative agent by testing its effect on the antioxidant biomarkers and lipid peroxidation. Methods: Dried leaves of V. amgydalina were extracted for 48 hrs and freeze dried. Acute toxicity was investigated in 25 rats. Thirty six rabbits were divided into 6 groups: groups I -III were normal; diabetes was induced in groups (IV -VI). Groups I and IV were normal and diabetic controls respectively. The animals were treated with aqueous leaf extract of V. amygdalina. Blood samples were collected and used for the study. Results: The reduction in body weight in the diabetic groups was regained following administration of the extract of V. amgydalina. The extract is considered safe and had little or no effect on blood glucose, MDA and GSH levels of the normal rabbits. Extract significantly reduced glucose and MDA concentrations but increased GSH levels in the diabetic rabbits. Similarly, the extract had no effect on the activities of SOD, CAT and GPx in normal rabbits, however in diabetic rabbits, the enzymes activities increased dose-dependently. Conclusion: This finding provides basis for the use of V. amgydalina as potential antidiabetic antioxidant agent and may be useful for its hypoglycemic property. INTRODUCTIONWith oxidative stress linked to metabolic or vascular disorder, diabetes becomes the best disease for studying the consequences of oxidative stress and its treatment. Diabetes mellitus is a multifactorial disease characterized by hyperglycemia, [2,3] lipoprotein abnormalities, [4] raised basal metabolic rate, [5] defect in reactive oxygen species scavenging enzymes [6] and high oxidative stress induced by the generation of highly reactive free radicals which are also involved in pancreatic destruction. [2,7] Insufficient removal of these free radicals can lead to oxidative damage to membranes; enhance susceptibility to lipid peroxidation, enzyme inactivation and nucleic acid damage. [8,6] Since oxidative stress is mediated by hyperglycemiainduced generation of free radical, it became clear that lowering blood glucose as well as scavenging the free radicals may ameliorate the oxidative stress thus providing an effective strategy for reducing diabetic mellitus and its complications. Attenuation of Oxidative Damage in Alloxan Induced[9] Hence compounds with both hypoglycemic and antioxidative properties would be very useful antidiabetic agents. We therefore considered a known hypoglycemic plant, Vernonia amygdalina and its effect on some endogenous biomarkers of oxidative stress: superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and lipid peroxidation...

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“…2,3 India has today become the diabetic capital of the world with over 20 million diabetics and this number is set to increase to 57 million by 2025. 4 DM is a multifactorial disease which is characterized by hyperglycemia, 5 lipoprotein abnormalities, 6 raised basal metabolic rate, 7 defect in reactive oxygen species scavenging enzymes 8 and high oxidative stress-induced damage to pancreatic beta cells. 9 It is ranked seventh among the leading causes of death and is considered third when its fatal complications are taken into account.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis and antidiabetic evaluation of oxazolone derivatives

et al. 2011

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A series of ten novel (2a-j) 4-arylidine 2-[4-methoxy phenyl] oxazol-5-one derivatives were synthesized and assayed in vivo to investigate their antidiabetic activities by streptozotocin-induced model in rat. These derivatives showed considerable biological efficacy when compared to rosiglitazone, a potent and wellknown antidiabetic agent as a reference drug. All the compounds were effective, amongst them 2d shows more prominent activity at 50 mg/k.g.p.o. The experimental results are statistically significant at P < 0.01 level.

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Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats

Cited by 57 publications

References 24 publications

Aqueous Leaf Extract Of Rothmannia Longiflora Improves Basal Metabolic Rate And Electrolyte Parameters In Alloxan Induced Diabetic Rats

Aqueous Leaf Extract Of Rothmannia Longiflora Improves Basal Metabolic Rate And Electrolyte Parameters In Alloxan Induced Diabetic Rats

Attenuation of Oxidative Damage in Alloxan Induced Diabetic Rabbits Following Administration of the Extract of the Leaves of Vernonia amygdalina.

Design, synthesis and antidiabetic evaluation of oxazolone derivatives

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