Vitamin C deficiency: rare cause of severe anemia with hemolysis

Shaikh, Hira; Faisal, Muhammad Salman; Mewawalla, Prerna

doi:10.1007/s12185-018-02575-w

Cited by 19 publications

(20 citation statements)

References 11 publications

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“…Ascorbic acid (vitamin C) deficiency causes a disease known as scurvy that, according to Shaikh et al [53], has other implications such as severe anemia with hemolysis (rash on neck, shoulders, chest, trunk and lower extremities). It is necessary to include in our diet citrus juice that has amount of ascorbic acid necessary for health; therefore, our results indicate that the rootstocks that had the highest value in ascorbic acid were 'FA 517' and 'FA 5' in all the cultivars and 'Eureka' had the lowest value of ascorbic acid on 'FA 13´rootstock, this coincides with results reported by Ortiz et al [54], where a similar behavior was found but with other varieties.…”

Section: Discussionmentioning

confidence: 99%

Influence of New Citrus Rootstocks on Lemon Quality

et al. 2020

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Citrus fruits are one of the main crops produced in the world with oranges, tangerines, lemons and grapefruits being among the most important. Among them, lemons are beneficial for human health because of their antioxidant activity, phenols and vitamin C. This study evaluates three rootstocks obtained in a Spanish breeding program (Valencian Institute for Agricultural Research (IVIA)): Forner-Alcaide 5 citrus rootstock (‘FA 5’), Forner-Alcaide 13 (‘FA 13’) and Forner-Alcaide 517 (‘FA 517’) grafted onto cultivars `Eureka´, `Verna´, `Fino 49’ and `Betera´. The results determined that rootstocks have influenced cultivars in terms of a decrease in the fruit size, weight, and thickness of the peel; but has increased the percentage of juice and soluble solids. With respect to phenol content and antioxidant activity, higher values were found with all cultivars studied on rootstocks ‘FA 13’, followed by ‘FA 517’. Cultivars that were most influenced by rootstocks were 'Bétera' and 'Eureka' in physical properties, while in chemical properties they were 'Verna' followed by 'Fino 49'. This investigation demonstrated the interaction of rootstocks on different cultivars in morphological, biochemical and nutraceutical characteristics.

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Section: Discussionmentioning

confidence: 99%

Influence of New Citrus Rootstocks on Lemon Quality

et al. 2020

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“…In a clinical study, 75 mg oral vitamin C in combination with oral N-acetyl cysteine did not reduce the risk of DGF [18]. According to the present findings, the effective dose to reduce IRI is at least 3 g of intravenous vitamin C [10]; so ineffectiveness in that study (24) can be justified by low dose and oral administration. Most studies using high doses of vitamin C have reported no side effects more than the placebo group [19].…”

Section: Introductionmentioning

confidence: 49%

“…On the other hand, Paul E. Marik, known for his vitamin C sepsis cocktail, stated in an editorial letter that vitamin C in a dose of about 6 g, not only does not increase hemolysis but also has a protective effect against it [23]. Otherwise, severe vitamin C deficiency is associated with hemolysis [24].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of high dose intravenous vitamin C on delayed allograft function in deceased donor kidney transplantation: a preliminary report

et al. 2020

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Background: Delayed graft function (DGF) can affect short-and long-term allograft outcomes in kidney transplant recipients. One of the pathophysiological pathways in the occurrence of DGF is ischemia-reperfusion injury (IRI). High dose intravenous vitamin C has proven efficacy in decreasing IRI consequences. Accordingly, we designed this study to assess the effect of high dose intravenous vitamin C on the incidence and duration of DGF. Methods: This is a pilot, single-center, double-blinded, randomized, placebo-controlled trial. In the treatment group, kidney transplant recipients received vitamin C infusion at the dose of 70 mg/kg diluted in 0.45% saline, and in another study arm, only the diluent solution was administered. Data regarding allograft function and other clinical information was recorded. Results: This preliminary study on 19 patients (9 cases in the vitamin C and 10 cases in the placebo group) showed that after administration of single, high dose vitamin C the incidence of DGF was not significantly different between the groups, but the duration of DGF was substantially shorter in the vitamin C group than the placebo group (7.33 ± 5.68 versus 19.66 ± 0.57 days; P = 0.02). Acute rejection episodes were more seen in the vitamin C group than in the placebo group. Although this data was not statistically significant (P = 0.37), it led to the termination of the study. Conclusion: A high dose of intravenous vitamin C before allograft implantation was effective in decreasing DGF duration but not DGF incidence. Trial registration: The trial was registered in the Iranian registry of clinical trials encoded IRCT20100111003043N13 on June 24, 2019.

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“…Scurvy is a rare disease among developed countries, where most foods are nutritious and provide adequate vitamin C. However, it can occur in psychiatric, alcoholic, socially isolated, elderly, or homeless patients (1)(2)(3). Its early symptoms are fatigue, followed by perifollicular hemorrhaging, leg edema, poor wound healing, gingival overgrowth, purpura, and ecchymosis (3).…”

Section: Introductionmentioning

confidence: 99%

An Unbalanced Diet Limited to the Consumption of Boiled Vegetables Led to the Onset of Scurvy

et al. 2022

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Scurvy is a rare disease caused by a vitamin C deficiency. Vitamin C is a water-soluble vitamin found in vegetables and fruits, but it is lost after boiling. A 59-year-old man presented with gingival pain after having a tooth extracted five years previously. Following the procedure, his diet comprised boiled vegetables to prevent pain. He then experienced bilateral lower leg pain, and computed tomography revealed intramuscular bleeding. His serum vitamin C level was below the detectable limit. His symptoms immediately improved with vitamin C administration. This case emphasized that consuming only boiled vegetables can lead to the onset of scurvy.

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Vitamin C deficiency: rare cause of severe anemia with hemolysis

Cited by 19 publications

References 11 publications

Influence of New Citrus Rootstocks on Lemon Quality

Influence of New Citrus Rootstocks on Lemon Quality

Evaluation of the effect of high dose intravenous vitamin C on delayed allograft function in deceased donor kidney transplantation: a preliminary report

An Unbalanced Diet Limited to the Consumption of Boiled Vegetables Led to the Onset of Scurvy

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