Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine

Xavier, S.M.L.; Barbosa, Cindy; Barros, D.O.; Silva, R.F.; Oliveira, Azauri Albano de; Freitas, Rivelilson Mendes de

doi:10.1016/j.neulet.2007.04.056

Cited by 110 publications

(79 citation statements)

References 20 publications

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“…It has been demonstrated that neurodegenerative diseases produced changes in nitric oxide metabolism and interacts with glutamatergic receptors to produce part of its stimulatory action on the CNS (Dymond & Crandall, 1976;Xavier et al, 2007;Freitas, 2009). The fall in nitrite content, after pretreatment with EO of C. limon, is most readily explained as a consequence of inhibiting formation of radicals, scavenges ROS, and lipid peroxidation products .…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Campêlo

Gonçalves

Feitosa³

et al. 2011

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Campêlo

Gonçalves

Feitosa³

et al. 2011

Pharmaceutical Biology

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“…Vit C dosage was determined according to previous studies (1,16,26). The rats were divided into four groups (six rats per group, except control.…”

Section: Experimental Conditionsmentioning

confidence: 99%

Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats

et al. 2017

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Like several other anticancer drugs, methotrexate (MTX) causes side effects, such as neuropathic pain, hepatotoxicity, and nephrotoxicity. Abnormal production of reactive oxygen species has been suspected in the pathophysiology of MTX-induced hepatorenal toxicity. Therefore, the aim of this study was to investigate the probable protective role of vitamin C (Vit C) on oxidative stress induced by MTX in the liver and kidney tissues of rats. A total of 32 rats were randomly and equally divided into four groups. The first group served as the control group. The second group received a single dose of 20 mg/kg of MTX intraperitoneally. To demonstrate our hypothesis, the third and the fourth groups received 250 mg/kg of Vit C for 3 days by oral gavage, with or without MTX treatment. At the end of the study, the liver and kidney tissues of the rats were collected and examined using histology. Both the tissues were assayed for malondialdehyde concentration and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. In hepatic and renal tissues, lipid peroxidation levels were increased, whereas SOD, CAT, and GSH-Px levels were decreased by MTX. All parameters, including CAT levels in hepatic tissue, were significantly restored after the administration of Vit C for 3 days. Similar to the biochemical findings, evidence of oxidative damage was examined in both types of tissues by histopathological examination. From the results of this study, we were able to observe that Vit C administration modulates the antioxidant redox system and reduces the renal and hepatic oxidative stress induced by MTX. Vit C can ameliorate the toxic effect of MTX in liver and kidney tissues of rat.

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“…Studies have shown that neurodegenerative diseases generate changes in nitric oxide metabolism, and interact with glutamate receptors to produce part of its stimulating action on the central nervous system (CNS) (Dymond & Crandall, 1976;Freitas, 2009;Silva et al, 2006;Souza et al, 2007;Xavier et al, 2007). In the nervous system, NO participates in various signaling processes, in tissue defense against pathogens, but is also a harmful agent when in excess, evoking oxidative reactions/reducing, producing RNS (Freitas, 2009;Migliorea & Coppedèb, 2009;Sueishi et al, 2011).…”

Section: Sod Activity In Mice Hippocampus Treated With P-cymene Acutelymentioning

confidence: 99%

Evaluation ofp-cymene, a natural antioxidant

Oliveira

Carvalho

Costa

et al. 2014

Pharmaceutical Biology

117

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Context: Several studies have demonstrated that essential oils and their major components have antioxidant activity. p-Cymene is a monoterpene and a major constituent of essential oils of various species of plants. Objective: This paper evaluated the antioxidant potential of p-cymene in the hippocampus of mice by determining the levels of thiobarbituric acid reactive substances (TBARS), nitrite content, and activity of catalase (CAT) and superoxide dismutase (SOD). Materials and methods: Swiss mice were intraperitoneally treated with 0.05% Tween 80 dissolved in 0.9% saline solution, ascorbic acid 250 mg/kg, and p-cymene at doses of 50, 100, and 150 mg/kg, respectively. After treatment, all groups were observed for 24 h, afterwards, the groups were euthanized for removal of the brain and dissection of the hippocampus. Results:The results of treatment with p-cymene were a significant decrease in lipid peroxidation and nitrite content at a dose of CYM 50: 65.54%, CYM 100: 73.29%, CYM 150: 89.83%, and CYM 50: 71.21%; CYM 100: 68.61% and CYM 150:67%, respectively, when compared with the control group. The results showed that at all tested doses, p-cymene produces an increase in SOD and catalase activity significantly at a dose of CYM 50: 22.7%, CYM 100: 33.9%, CYM 150: 63.1%, and CYM 50: 119.25%, CYM 100: 151.83% and CYM 150: 182.70%, respectively, when compared with the vehicle-treated group. Discussion and conclusion: The result of this study shows that p-cymene has an antioxidant potential in vivo and may act as a neuroprotective agent in the brain. This compound may present a new strategy in the development of treatment for many diseases in which oxidative stress plays an important pathophysiological role.

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Vitamin C antioxidant effects in hippocampus of adult Wistar rats after seizures and status epilepticus induced by pilocarpine

Cited by 110 publications

References 20 publications

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Antioxidant activity ofCitrus limonessential oil in mouse hippocampus

Vitamin C attenuates methotrexate-induced oxidative stress in kidney and liver of rats

Evaluation ofp-cymene, a natural antioxidant

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