Evaluation ofp-cymene, a natural antioxidant

Abstract

Context: Several studies have demonstrated that essential oils and their major components have antioxidant activity. p-Cymene is a monoterpene and a major constituent of essential oils of various species of plants. Objective: This paper evaluated the antioxidant potential of p-cymene in the hippocampus of mice by determining the levels of thiobarbituric acid reactive substances (TBARS), nitrite content, and activity of catalase (CAT) and superoxide dismutase (SOD). Materials and methods: Swiss mice were intraperitoneally treated with 0.05% Tween 80 dissolved in 0.9% saline solution, ascorbic acid 250 mg/kg, and p-cymene at doses of 50, 100, and 150 mg/kg, respectively. After treatment, all groups were observed for 24 h, afterwards, the groups were euthanized for removal of the brain and dissection of the hippocampus. Results:The results of treatment with p-cymene were a significant decrease in lipid peroxidation and nitrite content at a dose of CYM 50: 65.54%, CYM 100: 73.29%, CYM 150: 89.83%, and CYM 50: 71.21%; CYM 100: 68.61% and CYM 150:67%, respectively, when compared with the control group. The results showed that at all tested doses, p-cymene produces an increase in SOD and catalase activity significantly at a dose of CYM 50: 22.7%, CYM 100: 33.9%, CYM 150: 63.1%, and CYM 50: 119.25%, CYM 100: 151.83% and CYM 150: 182.70%, respectively, when compared with the vehicle-treated group. Discussion and conclusion: The result of this study shows that p-cymene has an antioxidant potential in vivo and may act as a neuroprotective agent in the brain. This compound may present a new strategy in the development of treatment for many diseases in which oxidative stress plays an important pathophysiological role.

Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects

“…Additionally, p ‐cymene is a monoterpene and a constituent of a number of essential oils such as Z. multiflora with antioxidant activity. The antioxidant effect of p ‐cymene in the hippocampus of mice indicated reduction effect of p ‐cymene on lipid peroxidation and nitrite content levels as well as increased CAT and SOD activities in mice hippocampus . The described studies indicate that other constituents of the plant such as linalool, γ‐terpinene, and p ‐cymene also contribute to antioxidant property of Z. multiflora .…”

Potent Chemopreventive/Antioxidant Activity Detected in Common Spices of the Apiaceae Family

“…In another study, anethole induced apoptosis, and combinations of anethole with cisplatin and oxaliplatin were highly synergistic (29). There are several other examples of phenolics such as p-cynene (ajowan and cumin), limonene (celery and caraway), thymol (ajowan) and β-pinene (cumin and celery) that have been shown to possess high antioxidant properties (30–32). In addition, the biological properties of polar and non-polar compounds from spices have been reviewed (33–35).…”

Hepatoprotective effect of ganoderma triterpenoids against oxidative damage induced bytert-butyl hydroperoxide in human hepatic HepG2 cells

“…SOD plays an important role in scavenging toxic intermediates of incomplete oxidation, which is regarded as one of the most primary antioxidant enzymes in the enzymatic defense mechanism (de Oliveira et al 2015). GSH, an abundant tripeptide in liver, is an important defense molecule against oxidising xenobiotics such as free radicals, peroxides and akylating agents, playing a pivotal role in the detoxification processes.…”