Vitamin C and vitamin E restore the resistance of GSH-depleted lens cells to H2O2

Antioxidant therapy attenuates oxidative insult caused by benzonidazole in chronic Chagas' heart disease

“…This is a plausible mechanism for cells to maintain the homeostasis of their total antioxidant capacity. Taken together, these observations suggest that cells and tissues can adaptively regulate GSH levels in response to changes in intracellular antioxidant capacity [51,52].…”

Amelioration of cisplatin-induced nephrotoxicity by extracts ofHemidesmus indicusandAcorus calamus

“…GSH, a tripeptide synthesized by glutathione synthase, is thought to be one of the most effective primary antioxidants against oxidizing agents (Shang et al, 2003). Reduced glutathione maintains cellular sulfhydryl groups and other structural proteins in stable form.…”

Effect of vitamin C and E activity on surgically removed cataractous human lens epithelium cells

“…100 µM in our results. Protective concentration from previous reports include 2.5mM of vitamin C for rat lens (23) 25-50 µM vitamin C and 5-40 µM Vitamin E in cultured rabbit lens epithelial cells (5). The effective concentration for both the vitamins appears to be higher than the already published reports.…”

“…Much evidence suggests that elevated intakes or plasma concentrations of antioxidants are associated with decreased risk of cataract (3,4). Antioxidant vitamins (C and E) have been shown to prevent cataract formation by blocking the oxidative modification of lens protein and lipid within the epithelium of the lens in many experimental models (in vitro) (5) and animal models (in vivo) (6). A fall in these vitamins's level in ocular humors and lens were also observed in cataract patients (7).…”