Vitamin B6 deficiency and diseases in elderly people – a study in nursing homes

Kjeldby, Ida Kindsbekken; Fosnes, Gunvor Steine; Ligaarden, Solveig Catharina; Farup, Per G.

doi:10.1186/1471-2318-13-13

Cited by 55 publications

(69 citation statements)

References 25 publications

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“…IL-4 production of lymphocytes in vitamin B6 deficient mice was promoted more than that in vitamin B6 normal mice, which exhibited a trend similar to that obtained by Doke et al [15]. The vitamin B6 deficiency did not change IFN- γ production, which was also described in a study by Kjeldby et al [8]. They found that vitamin B6 deficiency via the feeding of 4-deoxypyridoxine, a potent antagonist of vitamin B6 coenzyme, does not impair the production of IFN- γ in mice infected with Trichinella spiralis [8].…”

Section: Discussionsupporting

confidence: 85%

Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations

Bian

Shen

Zhang

et al. 2017

Journal of Immunology Research

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The immune system is critical in preventing infection and cancer, and malnutrition can weaken different aspects of the immune system to undermine immunity. Previous studies suggested that vitamin B6 deficiency could decrease serum antibody production with concomitant increase in IL4 expression. However, evidence on whether vitamin B6 deficiency would impair immune cell differentiation, cytokines secretion, and signal molecule expression involved in JAK/STAT signaling pathway to regulate immune response remains largely unknown. The aim of this study is to investigate the effects of vitamin B6 deficiency on the immune system through analysis of T lymphocyte differentiation, IL-2, IL-4, and INF-γ secretion, and SOCS-1 and T-bet gene transcription. We generated a vitamin B6-deficient mouse model via vitamin B6-depletion diet. The results showed that vitamin B6 deficiency retards growth, inhibits lymphocyte proliferation, and interferes with its differentiation. After ConA stimulation, vitamin B6 deficiency led to decrease in IL-2 and increase in IL-4 but had no influence on IFN-γ. Real-time PCR analysis showed that vitamin B6 deficiency downregulated T-bet and upregulated SOCS-1 transcription. This study suggested that vitamin B6 deficiency influenced the immunity in organisms. Meanwhile, the appropriate supplement of vitamin B6 could benefit immunity of the organism.

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Section: Discussionsupporting

confidence: 85%

Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations

Bian

Shen

Zhang

et al. 2017

Journal of Immunology Research

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“…This includes attention to medication reconciliation, polypharmacy, and discontinuation of high-risk geriatric medications when not indicated. (43; 55) For example, antipsychotic medications initiated in the acute care setting for agitated delirium are often continued without indication and potentially increase the risk for rehospitalization. (43; 46; 56) In addition, care should be made to minimize the use of urinary catheters, peripherally inserted central catheters (PICC lines), and other indwelling devices at the time of discharge, as these present potential safety hazards and increased risk of rehospitalization.…”

Section: Interventions For Patients Discharged To Post-acute Care Facmentioning

confidence: 99%

“…(43; 46; 56) In addition, care should be made to minimize the use of urinary catheters, peripherally inserted central catheters (PICC lines), and other indwelling devices at the time of discharge, as these present potential safety hazards and increased risk of rehospitalization. (55; 57; 58) Finally, patients transitioning to PAC facilities should be included in routine advanced care planning discussions. These should provide adequate information about short- and long-term prognosis, expectations about the PAC setting, and discussion of goals of care to ensure that future healthcare decisions align with patient preferences.…”

Section: Interventions For Patients Discharged To Post-acute Care Facmentioning

confidence: 99%

Reducing Hospital Readmission Rates: Current Strategies and Future Directions

et al. 2014

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New financial penalties for institutions with high readmission rates have intensified efforts to reduce rehospitalization. Several interventions that involve multiple components (e.g., patient needs assessment, medication reconciliation, patient education, arranging timely outpatient appointments, and providing telephone follow-up), have successfully reduced readmission rates for patients discharged to home. The effect of interventions on readmission rates is related to the number of components implemented, whereas single-component interventions are unlikely to reduce readmissions significantly. For patients discharged to post-acute care facilities, multicomponent interventions have reduced readmissions through enhanced communication, medication safety, advanced care planning, and enhanced training to manage common medical conditions that commonly precipitate readmission. To help hospitals direct resources and services to patients with greater likelihood of readmission, a number of risk stratification methods are available. Future work should better define the role of home-based services, information technology, mental health care, caregiver support, community partnerships, and new transitional care personnel.

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“…Recent studies have suggested, however, that even an apparently adequate B-6 intake may not suffice to guarantee normal plasma levels in elderly people, probably due to its lower absorption, higher catabolism, and impaired phosphorylation. 39 Given these premises, the higher RDA adopted by the US Food and Nutrition Board and the Italian Society of Human Nutrition for older women (ie, a daily intake of 1.5 mg), could be appropriate for older women, too.…”

Section: Discussionmentioning

confidence: 99%