Vitamin B12 levels of cerebrospinal fluid in patients with a variety of neurological disorders.

Abstract

SummaryThe vitamin B12 levels of cerebrospinal fluid were assayed microbiologically (Lactobacillus leichmannii method) using samples from 44 patients with various neurological disorders, 4 patients with megalo blastic anemia and 34 controls. Twenty-seven controls that did not receive vitamin B12 showed a mean cerebrospinal fluid vitamin B12 level of 21.5pg/ml (range: 0-60). No decrease in cerebrospinal fluid vitamin B12 level was seen in patients with subacute myelo-optico-neuropathy (SMON). High levels of cerebrospinal fluid vitamin B12 were observed only in the patients receiving long term administration of the vitamin. Intrathecal administration of vitamin B12 caused only a slight increase in serum vitamin B12 level after four hours. The existence of a blood brain barrier for vitamin B12 was suggested.

Rational Design for the Synthesis of Europium Vanadate-Encapsulated Graphene Oxide Nanocomposite: An Excellent and Efficient Catalyst for the Electrochemical Detection of Clioquinol

“…Later, a correlation between CQL and an epidemic of subacute myelo-optic neuropathy (SMON) was noted. SMON is an iatrogenic disease of the nervous system; it can directly cause disabling paralysis, abdominal pains, motor paralysis, lower limbs, impaired vision, sensory disturbances, and even death. , It is very common in Japan, where it was reported that more than 10 000 people were affected by this disease in the 1970s. Additionally, the physiological effect of CQL is caused by rapidly increasing histamine release and cell-mediated immunity.…”