Vitamin B12, folate and iron levels in primary nocturnal enuresis

Abstract

Objective:Folate, vitamin B12 and iron are important vitamin and minerals which play role in the development of nervous system. The aim of this study was looking at the presence of folate, vitamin B12 and iron deficiency among patients with Primary nocturnal enuresis (PNE) and possible relation between the delay of central nervous system (CNS) development, PNE and folate, vitamin B12 and iron states.Methods: Consecutively applied forty patients with PNE (23 girls and 17 boys) and otherwise normal thirty control subjects (17 girls and 13 boys) were included in the study. Average ages (in range) of PNE and the control group were 9.2(6-12) years and 9.3 (6-12) years accordingly. Age, height, weight, complete blood count, blood vitamin B12, folate, ferritin and iron values of both groups were recorded and compared to each other.Results:Average vitamin B12 and folate levels of patients with PNE were significantly and statistically lower compared to those of the control group. Average blood iron of patients with PNE was significantly higher than that of the control group and also average ferritin level of the PNE group was detected to be higher than the control group but this relation was statistically insignificant.Conclusion: Primary nocturnal enuresis is related to the delay in CNS maturation so it was thought that low vitamin B12 and folate which were found in patients with PNE may have role in the delay of CNS maturation. Additionally, further studies are needed to investigate the role of vitamin B12 and folate either alone or as combination in treatment of patients with PNE who have low vitamin B12and folate level.

Decreased vitamin D levels in children with primary mono-symptomatic nocturnal enuresis

“…Also, several studies highlighted the impact of deficiency of some vitamins in nocturnal enuresis etiopathogenesis. Enuretic children, for example, have lower levels of serum vitamin B12 and folate than their non-enuretic counterparts [18,19]. The present study showed that the NE group had a significantly lower mean vitamin D level than controls (19.0 ± 6.5 versus 23.89 ± 4.19).…”

Vitamin D and vitamin B 12 profiles in children with primary nocturnal enuresis, an analytical cross-sectional study

“…These studies have shown that a lack of essential nutrients can have detrimental effects on children’s cognitive abilities and motor neuron functions. Additionally, deficiencies in vitamin B 12 have been linked to behavioral changes, delayed puberty, and maturation of the central nervous system [ 18–20 ]. This could be the reason for the considerable prevalence of vitamin B 12 deficiency in our enrolled patients, a result that was closely stated [ 21 ].…”

Behavioral factors for predicting severity of enuresis and treatment responses in different compliance groups receiving behavioral therapy

“…It was also found that vitamin B12 and folate needed for CNS maturation was lower among patients with PNE compared to the control group. 18 Thus, the reason for children of poor appetite with severe symptoms may be nutrient insufficiency.…”