Vitamin B12 deficiency—need for a new guideline

Chui, Chung Hin; Lau, Fung Yi; Wong, Raymond; Soo, Oi Yan Yannie; Lam, Chuk Kwan; Lee, Alex; Leung, Ho Kei; So, Chiu Kui; Tsoi, Wai Chiu; Tang, Nelson L.S.; Lam, Wai Kei; Cheng, Gregory

doi:10.1016/s0899-9007(01)00666-9

Cited by 36 publications

(28 citation statements)

References 22 publications

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“…Oosterhuis et al analyzed the diagnostic value of an elevated MCV for B12 deficiency where the sensitivity was only 17% -30%, and up to 84% of the deficiency would be missed [26]. Any screening criteria selected would miss a significant number of B12 deficient patients, so there may be a case for universal B12 screening [39].…”

Section: Discussionmentioning

confidence: 99%

M.C.V. should not be the only criteria to order vitamin B12 for anemia under evaluation

Jain¹,

Kapil²,

Gupta³

2012

OJGas

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Section: Discussionmentioning

confidence: 99%

M.C.V. should not be the only criteria to order vitamin B12 for anemia under evaluation

Jain¹,

Kapil²,

Gupta³

2012

OJGas

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“…However, it seems that a cutoff value around 200 pmol/L has a relatively fair sensitivity and specificity [12]. Two cutoff values were used to define vitamin B12 deficiency: a liberal cutoff with serum concentrations lower than 206 pmol/L [13] and a restrictive cutoff value with serum concentrations lower than 140 pmol/L [14, 15], reflecting a deeper deficiency and a greater specificity. In addition to its acceptance as a cutoff for definite deficiency, the 140 pmol/L cutoff is similar to our institutional laboratory lower limit of reference range.…”

Section: Methodsmentioning

confidence: 99%

Vitamin B12 Deficiency and the Role of Gender: A Cross-Sectional Study of a Large Cohort

et al. 2018

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Background: Vitamin B12 deficiency is associated with hematological, neurological, and cardiovascular consequences. Epidemiologic data on these related illnesses indicate gender differences. Methods: A cross-sectional study was designed to examine gender differences in vitamin B12 deficiency among a healthy population. Data from healthy individuals aged 18–65, who were provided with a routine medical evaluation during 2000–2014, were retrieved from the medical charts. Individuals with background illnesses and those who had used medications or nutritional supplements were excluded. Vitamin B12 deficiency was defined by 2 cutoff values (206 and 140 pmol/L). The multivariate analysis was adjusted for age, body mass index, estimated glomerular filtration rate, hyperhomocysteinemia, folate deficiency, albumin, and transferrin saturation. Sensitivity analyses were implemented by excluding individuals with anemia, hyperhomocysteinemia, or folate deficiency and by age stratification. Results: In all, 7,963 individuals met the inclusion criteria. Serum vitamin B12 mean levels were 312.36 and 284.31 pmol/L for women and men respectively (p < 0.001). Deficiency prevalence was greater for men (25.5%) in comparison with women (18.9%; p < 0.001). Men were strongly associated with severe deficiency (adjusted OR 2.26; 95% CI 1.43–3.56). Conclusions: Among the healthy population, men are susceptible to vitamin B12 deficiency. This can be explained by neither diet habits nor estrogen effects. Genetic variations are therefore hypothesized to play a role.

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“…1 Studies have shown that prevalence of vitamin B 12 deficiency among elderly can range between 5% and 40% depending on the definition of vitamin B 12 deficiency used. [1][2][3][4][5][6][7] Many studies have used serum vitamin B 12 level with or without additional tests for its metabolites like homocysteine and methylmalonic acid (MMA) to estimate the prevalence of vitamin B 12 in the population. The most frequent serum vitamin B 12 cut-off to diagnose vitamin B 12 deficiency is 150 pmol/L (203 pg/mL).…”

Section: Prevalence Of Vitamin B 12 Deficiency Among the Elderlymentioning

confidence: 99%