M.C.V. should not be the only criteria to order vitamin B12 for anemia under evaluation

Jain, Rohit; Kapil, Menka; Gupta, GN

doi:10.4236/ojgas.2012.24037

Cited by 12 publications

(18 citation statements)

References 25 publications

(28 reference statements)

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“…Another study was done in Delhi by Kapil U and Sareen N (2014) who estimated that the prevalence of cobalamin deficiency was 67.2% for children in the age group 5-11 years and 68.3% for those in the age group 12-18 years. 13 Macrocytic anemia (high MCV) was not found to be significantly associated with vitamin B12 deficiency. A similar study done by Jain R et al (2012) in Jaipur, Kwok T et al (2002) in Hong Kong and Bhatia P et al (2012) showed no correlation between vitamin B12 levels and MCV in majority of the cases.…”

Section: Resultsmentioning

confidence: 88%

“…A similar study done by Jain R et al (2012) in Jaipur, Kwok T et al (2002) in Hong Kong and Bhatia P et al (2012) showed no correlation between vitamin B12 levels and MCV in majority of the cases. [13][14][15] The lower prevalence of macrocytic anemia amongst the cobalamin deficient children in our study could be because of the reason that we did not do serum MMA and homocysteine levels or urinary MMA levels in our study which is a more reliable marker of vitamin B12 deficiency. Furthermore, the higher incidence of macrocytic anemia among children having adequate serum cobalamin levels may be attributed to the presence of folate deficiency.…”

Section: Resultsmentioning

confidence: 99%

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Development delay in children with severe acute malnutrition and its association with Vitamin B12 deficiency

Adhualia

Maurya

Tewari

2019

Int J Contemp Pediatr

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Background: About half of the under five children are malnourished in India and so is morbidity associated with it. Malnutrition is also associated with multiple vitamin deficiency one of which is vitamin B12. Vitamin B12 is essential for DNA, RNA and protein synthesis; and for myelination of brain during the early childhood period. Deficiency of vitamin B12 can lead to megaloblastic anemia and neurological problems. So, authors aimed to look prevalence of vitamin B12 deficiency and; its hematological and neurological effects in severe acute malnourished children.Methods: it was an observational case control study, in which severe acute malnourished (SAM) children aged 0- 59 months who were admitted in Nutritional Rehabilitation Centre (NRC) were enrolled. Vitamin B12 levels were estimated and levels <200 pg/ml, 200-350 pg/ml, and >350 pg/ml were considered deficient, insufficiency and sufficient. Complete blood count was done for hematological effects and; developmental assessment was done to look for neurological effects.Results: Vitamin B12 was deficient, insufficient, normal in 15(16.3%), 25 (27.5%) and 52 (56.5%) children respectively. Vitamin B12 deficiency was significantly associated with hyperpigmentation and glossitis. Infant and young child feeding practices were not associated vitamin B12 deficiency. Macrocytic anemia was found in 23.4% SAM children and macrocytosis was not significantly associated with vitamin B12 deficiency. Developmental delay was found in 55.3 % children and was not significantly associated with severe acute malnutrition. Conclusions: There is high prevalence of Vitamin B12 deficiency and insufficiency in children with severe acute malnourished children. Macrocytic anemia and developmental delay are not significantly associated with vitamin B12 deficiency.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Development delay in children with severe acute malnutrition and its association with Vitamin B12 deficiency

Adhualia

Maurya

Tewari

2019

Int J Contemp Pediatr

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“…B 12 ‐deficient adults may be clinically and hematologically normal . In all three described cases, the mothers were asymptomatic but were found to have low B 12 levels and evidence of pernicious anemia on laboratory evaluation.…”

Section: Discussionmentioning

confidence: 84%

Vitamin B₁₂ Deficiency in Infancy: The Case for Screening

Singh

Schnabl

et al. 2016

Pediatric Blood & Cancer

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The classic principles put forth by Wilson and Jungner are often applied to determine the suitability of a condition for universal newborn screening. The three cases described here portray the harmful effects of vitamin B12 deficiency in infancy. The challenges and opportunities of early recognition and treatment are highlighted. Screening newborns would allow early detection and prevention of severe neurological damage in vitamin B12 -deficient infants and enable diagnosis of unrecognized maternal pernicious anemia in asymptomatic mothers. However, lack of standardized methodology and screening cutoffs present challenges to the use of current tandem mass spectrometry technologies for screening.

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“…Khanduri et al [6] reported 46.9% prevalence of vitamin B12 deficiency in 2005. Bhatia et al [7] reported 33.8% prevalence of vitamin B12 deficiency in 2010 and Jain et al [8] reported 36.5% prevalence of vitamin B12 deficiency in 2011. In this study, 80% (293/367) patients were having normal or low MCV even they are vitamin B12 deficient.…”

Section: Discussionmentioning

confidence: 99%

“…Bhatia et al [7] reported 75% patients were having normal or low MCV even they are vitamin B12 deficient. Jain et al [8] reported 89% patients were having normal or low MCV even they are vitamin B12 deficient. Oosterhuis et al [9] reported 84% patients were having normal or low MCV even they are vitamin B12 deficient.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of mean corpuscular volume in the detection of vitamin B12 deficiency

Vidja¹

2017

Int J Med Sci Public Health

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M.C.V. should not be the only criteria to order vitamin B12 for anemia under evaluation

Cited by 12 publications

References 25 publications

Development delay in children with severe acute malnutrition and its association with Vitamin B12 deficiency

Development delay in children with severe acute malnutrition and its association with Vitamin B12 deficiency

Vitamin B₁₂ Deficiency in Infancy: The Case for Screening

Diagnostic value of mean corpuscular volume in the detection of vitamin B12 deficiency

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M.C.V. should not be the only criteria to order vitamin B12 for anemia under evaluation

Cited by 12 publications

References 25 publications

Development delay in children with severe acute malnutrition and its association with Vitamin B12 deficiency

Development delay in children with severe acute malnutrition and its association with Vitamin B12 deficiency

Vitamin B12 Deficiency in Infancy: The Case for Screening

Diagnostic value of mean corpuscular volume in the detection of vitamin B12 deficiency

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Product

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Vitamin B₁₂ Deficiency in Infancy: The Case for Screening