Vitamin B12 deficiency is associated with coronary artery disease in an Indian population

Kumar, Jitender; Garg, Gaurav; Sundaramoorthy, Elayanambi; Prasad, Padmini; Karthikeyan, Ganesan; Ghosh, Saurabh; Sengupta, Shantanu

doi:10.1515/cclm.2009.074

Cited by 32 publications

(31 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vegetarians are more likely to be deficient in vitamin B6, vitamin B 12 , and folate which are the essential cofactors for homocysteine metabolism. Recent evidence strongly suggests that too little vitamin B 12 can lead to high level of homocysteine [28][29][30][31][32][33]. In our study, we have seen that weight and alcohol intake are statistically significant predictors of homocysteine (P = 0.006 and P = 0.036, respectively).…”

Section: Discussionsupporting

confidence: 58%

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Das¹,

Ghose²,

Borah³

et al. 2010

Indian J Clin Biochem

View full text Add to dashboard Cite

Till date no community based data on plasma homocysteine is available in North Eastern Region. Hence, the present study was conducted to analyze and correlate the plasma homocysteine level with some life style factors like diet, alcohol intake, smoking habit and body weight, in a cross-section of population. 12 h fasting samples of 970 apparently healthy, Assamese population of both genders in the age group of 35-86 years, mostly from the urban area of Assam were tested for plasma total homocysteine level over a period of 3 years. Out of 970 volunteers, hyperhomocysteinemia was detected in 533 (55%) individuals with a mean value of 18.41 lmol/l. Of that hyperhomocysteinemia, 89.1% were in the range of moderately high and rest 10.9% were intermediate high. Another finding was that males had a tendency towards greater value (mean = 20.36 lmol/l) than females (mean = 16.37 lmol/l). It was observed that the relationship of homocysteine levels to gender and some of the life style factors were also significant.

show abstract

Section: Discussionsupporting

confidence: 58%

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Das¹,

Ghose²,

Borah³

et al. 2010

Indian J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Studies also show that exogenous supplementation of these nutrients to mothers during and prior to pregnancy helps reduce the risk of these disorders in the children [9]. Multiple investigations from different parts of the Indian subcontinent have confirmed, with minor differences, high prevalence of elevated Hcy, deficiency of Vit-B12 and folates along with strong genotype correlation with respect to Hcy levels in the population [10,11,12,13]. Further their association with different disorders has also been demonstrated [11,12]…”

Section: Introductionmentioning

confidence: 99%

Low Birthweight (LBW) and Neonatal Hyperbilirubinemia (NNH) in an Indian Cohort: Association of Homocysteine, Its Metabolic Pathway Genes and Micronutrients as Risk Factors

et al. 2013

View full text Add to dashboard Cite

Background & AimsIndian subcontinent has the highest child mortality rates along with a very high frequency of low birthweight (LBW). Folate and vitamin B12 (Vit-B12) are necessary during foetal development and their deficiency prevalence in Indians is very high. The objective of the present paper is to assess whether foetal homocysteine (Hcy)/folate metabolic pathway genes, their cofactors and homocysteine level independently (or collectively) predispose children to Low birth weight.MethodsCord blood was collected for the study. Frequency of 5 SNPs in 4-Hcy-pathway genes, and levels of Hcy, Vit-B12 and folate were evaluated.ResultsOf the 421 newborns recruited for the study, 38% showed low birth weight (<2.5kg) and 16% were preterm babies. 101 neonates developed neonatal hyperbilirubinemia (NNH). High prevalence of Vit-B12 (65%) and folate (27%) deficiency was observed in newborns along with hyperhomocystinemia (hypHcy-25%). Preterm delivery, micronutrient deficiency, hypHcy and MTHFR 677T SNP are associated as risk factor while G allele of TCN2 C776G is protective against LBW. MTHFR 677T allele and folate deficiency are also independent risk factors for NNH.ConclusionWe record the highest incidence of Vit-B12, folate deficiency and elevated Hcy levels, of all the studies so far reported on neonates. These together with MTHFR 677T are potential risk factors for LBW. Association of impaired folate/Hcy metabolism with NNH is reported for the first time and the possible way of interaction is discussed. It appears that proper nutritional management during pregnancy would reduce the risk of complex clinical outcomes.

show abstract

“…Dietary Vitamin B12 deficiency has been shown to be a severe problem in the Indian subcontinent,[2–7] Mexico, Central and South America and selected areas in Africa. [8] It is also seen in immigrant populations[910] in the Western world, probably due to vegetarian diet.…”

Section: Discussionmentioning

confidence: 99%

Spinal MR imaging in Vitamin B12 deficiency: Case series; differential diagnosis of symmetrical posterior spinal cord lesions

Anitha

Kesavadas

2013

Ann Indian Acad Neurol

View full text Add to dashboard Cite

show abstract

Vitamin B12 deficiency is associated with coronary artery disease in an Indian population

Abstract: We believe that, when vitamin B12 is deficient, homocysteine is rapidly metabolized via the transsulfuration pathway leading to increased cysteine levels.

Cited by 32 publications

References 18 publications

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

A Community Based Study of the Relationship Between Homocysteine and Some of the Life Style Factors

Low Birthweight (LBW) and Neonatal Hyperbilirubinemia (NNH) in an Indian Cohort: Association of Homocysteine, Its Metabolic Pathway Genes and Micronutrients as Risk Factors

Spinal MR imaging in Vitamin B12 deficiency: Case series; differential diagnosis of symmetrical posterior spinal cord lesions

Contact Info

Product

Resources

About