Spinal MR imaging in Vitamin B12 deficiency: Case series; differential diagnosis of symmetrical posterior spinal cord lesions

Anitha, S.; Kesavadas, C.

doi:10.4103/0972-2327.112487

Cited by 23 publications

(13 citation statements)

References 19 publications

(14 reference statements)

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“…MRI typically shows a mass with a perivascular pattern typically most dense in the pontine and peripontine regions [24,27,28]. The MRI series in our case did not confirm any significant abnormity in these pathognomonic regions indicating CLIPPERS.…”

Section: ) Clipperscontrasting

confidence: 46%

An unusual Guillain-Barré Syndrome mimic: a case of Spinal ADEM and review of the literature

Roshanisefat¹,

Henderson²

2016

Clin Case Rep Rev

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Section: ) Clipperscontrasting

confidence: 46%

An unusual Guillain-Barré Syndrome mimic: a case of Spinal ADEM and review of the literature

Roshanisefat¹,

Henderson²

2016

Clin Case Rep Rev

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“…47,50,54 Other imaging findings include mild cord expansion consistent with swelling, and nonspecific T2 hyperintensities, predominantly affecting the posterior columns, and in some cases the corticospinal tracts. 47,50,55 The cervical and upper thoracic spinal cord are most commonly affected. 50 The lesions usually span several spinal levels.…”

Section: Cobalamin (Vitamin B 12 ) Deficiencymentioning

confidence: 99%

Metabolic and Toxic Myelopathies

Slama

Berkowitz

2021

Semin Neurol

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Metabolic and toxic causes of myelopathy form a heterogeneous group of disorders. In this review, we discuss the causes of metabolic and toxic myelopathies with respect to clinical presentation, pathophysiology, diagnostic testing, treatment, and prognosis. This review is organized by temporal course (hyperacute, acute, subacute, and chronic) and etiology (e.g., nutritional deficiency, toxic exposure). Broadly, the myelopathies associated with dietary toxins (neurolathyrism, konzo) and decompression sickness present suddenly (hyperacute). The myelopathies associated with heroin use and electrical injury present over hours to days (acutely). Most nutritional deficiencies (cobalamin, folate, copper) and toxic substances (nitrous oxide, zinc, organophosphates, clioquinol) cause a myelopathy of subacute onset. Vitamin E deficiency and hepatic myelopathy cause a chronic myelopathy. Radiation- and intrathecal chemotherapy-induced myelopathy can cause a transient and/or a progressive syndrome. For many metabolic and toxic causes of myelopathy, clinical deficits may stabilize or improve with rapid identification and treatment. Familiarity with these disorders is therefore essential.

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“…Preferential involvement of the cervical spine may be related to higher density of myelinated fibers in the fasciculus gracilis in this region . Contrast enhancement is typically absent or mild (Figure ) and signal abnormality in the cord usually improves after treatment . Other entities that present with preferential involvement of the dorsal columns of the spinal cord include HIV vacuolar myelopathy, copper deficiency, vitamin E deficiency, neurosyphilis (tabes dorsalis), and hereditary conditions including Friedreich's ataxia and leukoencephalopathy with brainstem and spinal involvement and lactate elevation (LBSL) …”

Section: Imagingmentioning

confidence: 99%