Vitamin B12 Deficiency In Chronic Kidney Disease

Patil, Rohan; Bhosle, Deepak; Malik, Rizwan Abdul Hakim

doi:10.9790/0853-1509032225

Cited by 7 publications

(3 citation statements)

References 22 publications

(29 reference statements)

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“…The incidence of iron deficiency anemia in India is 60% in urban and 69% in rural population [3]. It is also a common disorder in pregnancy and CKD [4]. This limits the quality of the patient's life.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia among Chronic Kidney Disease Patients in Kaveri Delta Region, Tamilnadu, India

Muniyandi

Shanmugam

Ramanathan

et al. 2016

BJMMR

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Section: Introductionmentioning

confidence: 99%

Prevalence of Iron Deficiency Anemia among Chronic Kidney Disease Patients in Kaveri Delta Region, Tamilnadu, India

Muniyandi

Shanmugam

Ramanathan

et al. 2016

BJMMR

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“…In contrast to Stabler's study [ 28 ], Patil et al [ 29 ] identified a high percentage (56%) of CKD patients who were vitamin B12 deficient. Because of pharmaceutical interactions, restricted eating habits, and inadequate nutrition, which could lead to vitamin B12 deficiency, patients with ESRD are more likely to experience nutritional deficiencies.…”

Section: Discussionmentioning

confidence: 81%

Serum Vitamin B12 Deficiency in Chronic Hemodialysis Patients

Mushtaq,

Usmani,

Hameed

et al. 2024

Cureus

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Introduction Essential vitamins like folate and vitamin B12 are crucial for many physiological functions. Patients with renal failure undergoing regular hemodialysis in the general population may experience harmful effects from vitamin B12 deficits. Therefore, this study aimed to determine the frequency of vitamin B12 deficiency in hemodialysis patients and its association with other clinical parameters. Methods This cross-sectional study was conducted at the dialysis unit of Patel Hospital and Lifeline Hospital, Karachi, using a non-probability consecutive sampling technique after obtaining ethical approval from Lifeline Hospital (LLH/HR/02-22). The study duration was six months, from January 10, 2023, to July 22, 2023. A total of 135 adult renal failure patients with ages >18 and <70 years on maintenance hemodialysis for >1 year were included in the study. The chi-square test was used to determine the association between vitamin B12 deficiency and age and gender. A p-value of 0.05 was considered statistically significant. Results The study findings showed that out of 135 patients, 82 (60.7%) were males and 53 (39.3%) were females, with a mean age of 50.80 ± 10.03 years. The duration of hemodialysis was approximately 1-2 years in 98 (72.6%) patients, 2-3 years in 27 (20.0%) patients, and 3-4 years in only 9 (6.7%) patients. The mean serum vitamin B-12 levels were 411.61 ± 224.95 pg/ml, with 30 (22.2%) of the subjects being deficient. In terms of duration of hemodialysis, there was a significant association (p= 0.013). Between patients with normal 4 (4%) and deficient 5 (17%) vitamin B12 and 3-4 years of hemodialysis. Conclusion In this study, we found that a significant proportion of patients on chronic hemodialysis had vitamin B12 deficiency. Moreover, vitamin B12 deficiency was significantly associated with duration of hemodialysis. Therefore, we recommend periodic vitamin B12 testing in hemodialysis patients to avoid any associated complications.

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“…This deficiency is caused by inadequate nutrition and loss through the high fluxhemodialysis procedure. In our study, the high-flux hemodialysis was not used (29) . Seven (9.4%) of the 169 patients have high levels of vitamin B12.…”

Section: Discussionmentioning

confidence: 91%

The Prevalence of Vitamin B12 Deficiency in Hemodialysis Patients

Alkrush,

Mahmood

2023

JSMC

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BackgroundVitamin B12 is a water-soluble vitamin in several normal cellular functions. Low vitamin B12 has been associated with high concentrations of homocysteine and can lead to health complications. In addition to metabolic alteration and restricted food products allowable in renal failure patients, vitamin B12 is actively removed by hemodialysis with high flux membranes. ObjectiveTo detect the prevalence of vitamin B12 levels in hemodialysis patients and its relation to the duration of dialysis and daily protein intake. MethodThis cross-section observational multicenter study was conducted on 169 hemodialysis patients in four Sulaimani Governorate centres. A questionnaire used to gather data included patient, dialysis, diet, and medication information. Blood investigation was taken to detect the vitamin B12 level and mean corpuscular volume. ResultsTwenty-nine patients (17.1 %) had vitamin B12 deficiency. High flux filter hemodialysis was not used in all the centres included in this study. No cases with four hours of dialysis sessions had vitamin B12 deficiency. All the patients were on sub-optimum protein diet restriction. No cases of vitamin B12 deficiency were present in patients receiving protein of 0.6-0.7 gm/kg/day. All our patients had normochromic normocytic anaemia. ConclusionOur patients have an average percentage of vitamin B12 deficiency compared to other centres worldwide. The main causes of vitamin B12 deficiency in our patients were the sub-optimum restriction of protein diet and the sub-optimum dialysis.

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Vitamin B12 Deficiency In Chronic Kidney Disease

Cited by 7 publications

References 22 publications

Prevalence of Iron Deficiency Anemia among Chronic Kidney Disease Patients in Kaveri Delta Region, Tamilnadu, India

Prevalence of Iron Deficiency Anemia among Chronic Kidney Disease Patients in Kaveri Delta Region, Tamilnadu, India

Serum Vitamin B12 Deficiency in Chronic Hemodialysis Patients

The Prevalence of Vitamin B12 Deficiency in Hemodialysis Patients

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