Vitamin B12 Activates the Wnt-Pathway in Human Hair Follicle Cells by Induction of &amp;lt;i&amp;gt;beta&amp;lt;/i&amp;gt;-Catenin and Inhibition of Glycogensynthase Kinase-3 Transcription

Krugluger, Walter; Stiefsohn, Karl; Laciak, Katharina; Moser, Karl; Claudia, Moser

doi:10.4236/jcdsa.2011.12004

Cited by 11 publications

(11 citation statements)

References 19 publications

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“…[ 7 ] Vitamin B12 facilitates stabilization of the initial anagen phase of hair follicle. [ 8 ] In the current study, serum Vitamin B12 levels were significantly low in individuals with PHG as compared to the controls ( P < 0.001).…”

Section: Discussionmentioning

confidence: 46%

Factors associated with premature hair graying in a young Indian population

Chakrabarty¹,

Krishnappa²,

Gowda³

et al. 2016

Int J Trichol

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Context:Although the primary cause of premature hair graying (PHG) is considered to be genetic, certain environmental factors also play a role. Trace element deficiencies such as Vitamin B12, Vitamin D3, and calcium may also be associated with PHG. However, India-specific data are relatively sparse.Aims:The present study aimed at identifying factors associated with PHG in Indian patients.Settings and Design:A case–control study was conducted at a trichology clinic in Bengaluru between October 2013 and April 2014 with a total of 37 cases of PHG and 37 age- and gender-matched controls.Materials and Methods:A total of 100 subjects were investigated for various parameters such as hemoglobin, serum ferritin, zinc, copper, calcium, Vitamin B12, and Vitamin D after obtaining informed consent.Statistical Analysis Used:Chi-square test was used to compare proportions between groups. Means were compared between groups using Student's t-test.Results:Serum ferritin levels were lower in patients with PHG as compared to the control group and the differences were statistically significant (P < 0.001). Furthermore, as compared to the controls, patients with PHG had lower serum Vitamin B12 levels (P < 0.001). Individuals with PHG had significantly lower levels of high-density lipoprotein cholesterol (HDL-C) as compared to the control group (P < 0.001). Significant proportions of patients with PHG had a sedentary lifestyle and admitted to having irregular eating habits.Conclusion:PHG is associated with low serum ferritin, Vitamin B12, and HDL-C levels in Indian patients aged <25 years. However, studies with large sample sizes may be required to conclusively define these putative associations.

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Section: Discussionmentioning

confidence: 46%

Factors associated with premature hair graying in a young Indian population

Chakrabarty¹,

Krishnappa²,

Gowda³

et al. 2016

Int J Trichol

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“…During melanin biosynthesis, tyrosinase is synthesized from the initial anagen stage to the late anagen stage and is not synthesized in the catagen and telogen stage [Ideta et al, ]. In addition, β‐catenin provides a crucial signal for the telogen‐to‐anagen transition, and the chronic activation of β‐catenin has been found to result in changes consistent with the induction of abnormal growth stages in telogen hair follicles [Krugluger et al, ]. Therefore, the anagen phase plays an important role in melanin production in dermal papilla cells.…”

Section: Discussionmentioning

confidence: 99%

Synergistic effect of rice bran extract and extremely low‐frequency electromagnetic fields on dermal papilla/melanocytes in melanogenesis

Kwon

Kim

Jang

et al. 2018

Bioelectromagnetics

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Melanocytes in hair are located around dermal papilla cells at the tip of the hair follicle. In this study, we examined the melanogenesis of a three‐dimensional (3D) hair dermal papilla model treated with natural extracts and electromagnetic fields (EMFs). The 3D model involved dermal papilla‐like tissue (DPLT), an aggregation of a mixture of dermal papilla cells, and melanocytes in microwells. Rice bran extract (RBE), an EMF, and RBE/EMF were applied to different DPLT groups. The LDH assay indicated no cell stress in all experimental groups, and detection of tyrosinase activity demonstrated high activity in the RBE/EMF group. Western blot analysis of the RBE, EMF, and RBE/EMF groups revealed increased MITF, TRP‐1, and tyrosinase expression. In addition, the mRNA expression of ET‐1, laminin, bFGF, β‐catenin, MITF, and tyrosinase was increased in the RBE/EMF group, as demonstrated by RT‐qPCR analysis. HMB45 and Fontana–Masson immunostaining showed that the RBE/EMF group had the highest melanin content. Therefore, RBE and EMF may be used as a material and therapy, respectively, for the treatment of vitiligo and white hair, through activation of melanogenesis in melanocytes. Bioelectromagnetics. 39:595–603, 2018. © 2018 The Authors. Bioelectromagnetics Published by Wiley Periodicals, Inc..

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“…[27] vitamin B12 stabilize the initial anagen phase of the hair follicle and might decrease post transplantational effluvium in hair restoration surgery. [28] Premature graying of hair may be a manifestation of pernicious anemia. However, our study didn’t reveal any significant difference in the serum vitamin B12 values of cases and controls.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children

et al. 2013

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Background:Hair pigmentation is one of the most conspicuous phenotypes in humans ranging from black, brown, and blonde to red. Premature graying of hair occurs more commonly without any underlying pathology but is said to be inherited in autosomal dominant pattern. Premature graying has been shown to be associated with a few of the autoimmune disorders. A role for environmental factors and nutritional deficiencies has also been postulated. However, to date the exact etiology of premature graying has not been established.Aim:The objective of our study was to conduct an epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children of the semi-urban area.Materials and Methods:A total of 35 cases and controls were investigated for various parameter such as Hemoglobin, total iron binding capacity, serum ferritin (S. Ferritin), serum calcium (S. Ca), serum iron (S. Iron), vitamin B12, and vitamin D3 after taking informed consent. Epidemiological and investigations correlation was established using the Chi-square and Mann Whitney test and P < 0.05 values were considered significant.Result:Among the various laboratory parameters S. Ca, S. Ferritin and vitamin D3 were low in patients with premature graying of hair. There was significant high number of vitamin D3 deficient and insufficient among the cases compared to the controls.Conclusion:According to our study S. Ca, S. Ferritin, vitamin D3 may play a role in premature graying of hair in our society.

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Vitamin B12 Activates the Wnt-Pathway in Human Hair Follicle Cells by Induction of <i>beta</i>-Catenin and Inhibition of Glycogensynthase Kinase-3 Transcription

Cited by 11 publications

References 19 publications

Factors associated with premature hair graying in a young Indian population

Factors associated with premature hair graying in a young Indian population

Synergistic effect of rice bran extract and extremely low‐frequency electromagnetic fields on dermal papilla/melanocytes in melanogenesis

Epidemiological and investigative study of premature graying of hair in higher secondary and pre-university school children

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