Vitamin B1, B2, B3, B5, and B6 and the Immune System

Mikkelsen, Kathleen; Apostolopoulos, Vasso

doi:10.1007/978-3-030-16073-9_7

Cited by 52 publications

(51 citation statements)

References 67 publications

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“…Thiamine is able to improve immune system function and has been shown to reduce the risk of type-2 diabetes, cardiovascular disease, aging-related disorders, kidney disease, cancer, mental disorders and neurodegenerative disorders [ 6 ]. Thiamine deficiency affects the cardiovascular system, causes neuroinflammation, increases inflammation and leads to aberrant antibody responses [ 6 ]. As antibodies, and importantly T-cells, are required to eliminate the SARS-CoV-2 virus, thiamine deficiency can potentially result in inadequate antibody responses, and subsequently more severe symptoms.…”

Section: Can Vitamin B Be Used To Manage Covid-19?mentioning

confidence: 99%

“…Pantothenic acid has a number of functions, including cholesterol- and triglyceride-lowering properties, improves wound healing, decreases inflammation and improves mental health [ 6 ]. Even though there are limited studies demonstrating the effects of pantothenic acid on the immune system, it is a viable vitamin for future investigation.…”

Section: Can Vitamin B Be Used To Manage Covid-19?mentioning

confidence: 99%

“…There is a need to highlight the importance of vitamin B because it plays a pivotal role in cell functioning, energy metabolism, and proper immune function [ 6 ]. Vitamin B assists in proper activation of both the innate and adaptive immune responses, reduces pro-inflammatory cytokine levels, improves respiratory function, maintains endothelial integrity, prevents hypercoagulability and can reduce the length of stay in hospital [ 7 , 8 ].…”

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Be well: A potential role for vitamin B in COVID-19

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Section: Can Vitamin B Be Used To Manage Covid-19?mentioning

confidence: 99%

Section: Can Vitamin B Be Used To Manage Covid-19?mentioning

confidence: 99%

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Be well: A potential role for vitamin B in COVID-19

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“…It has been reported that vitamin B1 has a potential anti-inflammatory effect while acting on macrophages, and it suppresses oxidative stress evoked NF-kappa B activation (Spinas et al 2015). Thiamine deficiency affects the immune system due to various pathological initiations like increased inflammation, oxidative stress, metabolic disturbances, which further leads to the production of aberrant antibodies (Mikkelsen and Apostolopoulos 2019) It was documented that thiamine plays a significant role in eliminating the SARS-CoV-2 virus by triggering humoral and cell-mediated immunity. Hence, sufficient levels of thiamine help in building immunity against SARS-CoV-2 patients (Shakoor et al 2020b).…”

Section: Vitamin B1 (Thiamine)mentioning

confidence: 99%

Role of vitamins and minerals as immunity boosters in COVID-19

et al. 2021

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) known as coronavirus disease , emerged in Wuhan, China, in December 2019. On March 11, 2020, it was declared a global pandemic. As the world grapples with COVID-19 and the paucity of clinically meaningful therapies, attention has been shifted to modalities that may aid in immune system strengthening. Taking into consideration that the COVID-19 infection strongly affects the immune system via multiple inflammatory responses, pharmaceutical companies are working to develop targeted drugs and vaccines against SARS-CoV-2 COVID-19. A balanced nutritional diet may play an essential role in maintaining general wellbeing by controlling chronic infectious diseases. A balanced diet including vitamin A, B, C, D, E, and K, and some micronutrients such as zinc, sodium, potassium, calcium, chloride, and phosphorus may be beneficial in various infectious diseases. This study aimed to discuss and present recent data regarding the role of vitamins and minerals in the treatment of COVID-19. A deficiency of these vitamins and minerals in the plasma concentration may lead to a reduction in the good performance of the immune system, which is one of the constituents that lead to a poor immune state. This is a narrative review concerning the features of the COVID-19 and data related to the usage of vitamins and minerals as preventive measures to decrease the morbidity and mortality rate in patients with COVID-19.

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“…Treatment with nicotinamide was able to significantly repress neutrophil infiltration into lungs during ventilator induced lung injury but had no effect on cytokine production or protein leakage and was also found to paradoxically lead to hypoxaemia 18 . Pyridoxine plays a vital role in antibody production and immune system regulation 19 . Thus, B complex vitamins are a valuable adjunct in COVID-19 therapy.…”

Section: Nutritional Supplementationmentioning

confidence: 99%

COVID-19: A review of drugs and therapies for children

Jameel

Taksande

2020

Sri Lanka J Child Health

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Introduction The World Health Organisation (WHO) has declared the disease as Corona Virus Disease (COVID-19) due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Coronavirus infection was restricted to animals but gained importance in medicine as it acted as the aetiological factor responsible for the SARS epidemic in 2002 in the Guangdong province of China 1. WHO reported its spread to over 26 countries, causing infections in 8096 individuals and 774 deaths 2. This group of viruses caused another outbreak in 2012 as Middle Eastern Respiratory Syndrome (MERS) 3. Since December 2019, a strain of novel coronavirus has wreaked havoc in the Hubei province of China and has caused severe pneumonia 4. On March 11, the WHO declared it a 'pandemic'. More than 1.5 million cases of COVID 19 have been reported with a mortality of over 85,000 across 212 countries 5. The largest study on children with COVID 19 to date includes an analysis of 2143 children documented from 16 th of January, 2020 to 8 th of February, 2020. This study showed that only 1 child had died while 5.9% were critical or had severe pneumonia, the majority having mild to moderate illness 6. Although pneumonia remains the chief cause of death among the under 5 year age category, the features of COVID-19 pneumonia were relatively milder compared to pneumonia of other aetiologies and the prognosis was better with deaths being extremely rare 6-8. Clinical presentation in infants and children Since the outbreak of the pandemic, 9 infants were reported to be positive till 6 th February, 2020 in _________________________________________

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Vitamin B1, B2, B3, B5, and B6 and the Immune System

Cited by 52 publications

References 67 publications

Be well: A potential role for vitamin B in COVID-19

Be well: A potential role for vitamin B in COVID-19

Role of vitamins and minerals as immunity boosters in COVID-19

COVID-19: A review of drugs and therapies for children

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