Vitamin B₁₂ treatment reduces mononuclear DNA damage

Abstract

DNA damage is increased in children with vitamin B(12) deficiency and in their mothers. DNA damage scores were significantly improved through vitamin B(12) therapy 8 days after the first injection, however, they were still significantly higher than those of controls.

Folate rescues vitamin B 12 depletion-induced inhibition of nuclear thymidylate biosynthesis and genome instability

“…Insufficient concentrations of intracellular folate or impairments in nuclear localization of the de novo dTMP biosynthesis complex can lead to elevated uracil levels in DNA (20,21). Low intracellular vitamin B 12 concentrations and/ or status can increase markers of genome instability, including chromosomal abnormalities (22,23), DNA strand breaks (24), and uracil content in DNA (25,26). The mechanisms underlying the interactions between folate and vitamin B 12 in maintaining genome stability, and their contributions to human disease, are unresolved.…”

Blood micronutrients and DNA damage in children

“…The great majority of studies investigating factors associated with DNA damage have been conducted in adults. The focus of the studies conducted in children to date has been on the effects of environmental pollutants , although there have been some reports of increased MNi frequency and chromosome damage among children with significant malnutrition , deficient protein intake , obesity , or low blood levels of vitamin B12 or iron .…”

Leukocyte DNA Damage and Wound Infection after Nitrous Oxide Administration

“…5 Biochemically, nitrous oxide inhibits methionine synthase by oxidizing the cobalt atom in the cobalamin molecule, [6][7][8] resulting in acute depletion of intracellular tetrahydrofolate. Since dietary folate and cobalamin deficiencies are known to induce uracil misincorporation, base damage, and strand breakage during synthesis of DNA, [9][10][11][12][13][14][15] we hypothesized that nitrous oxide exposure may produce acute DNA damage. This may compromise host defense mechanisms and predispose patients to surgical wound infection.…”