Vitamin B Complex as a Potential Therapeu Tical Modality in Combating Peripheral Nerve Injury

Nedeljković, Predrag; Đačić, Sanja; Kovačević, Miljan; Peković, Sanja; Vučević, Dragana; Nedeljković, Biljana Božić

doi:10.5633/amm.2018.0214

Cited by 4 publications

(8 citation statements)

References 39 publications

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“…Glycine max had the highest vitamin B 3 content (0.031mg/g) compared to the two Vigna species kanannade and gayan-gayan with vitamin B3 content of 0.019 and 0.022mg/g respectively. B vitamins have been suggested to elucidate a possible therapeutic potential in the treatment and management of peripheral nerve injury (Nedeljkovic et al, 2018). Values obtained for vitamin B6 were found to be the lowest compared to other vitamins that were analysed ( Vitamins B 1 and B 3 ).…”

Section: Quantitative Determination Of Water Soluble Vitamins Mineramentioning

confidence: 99%

Quantitative determination of water soluble vitamins, minerals and proximate compositions of three varieties of beans in Bauchi State Nigeria

Mohammed¹,

Matinja²,

Tijjani³

et al. 2019

Glo Jnl Pure Appl Sci

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The quantitative determination of water soluble vitamins, minerals and proximate compositions of three varieties of beans in Bauchi State, Nigeria, was carried out in this study. Three varieties of beans which includes one of the most commonly consumed species of cowpea (Vigna unguiculata) locally called Kanannade, the least consumed (most rare) specie of cowpea (Vigna unguiculata) locally called gayan-gayan and soybean (Glycine max) locally called waken soya found in Bauchi State, Nigeria were analysed. Results for the determination of the proximate composition shows that soybean (Glycine max) among three different samples had the highest protein content (34.21 %), ash content (3.11 %), Crude fat (25.30 %). While Cowpea (kanannade) has the highest Carbohydrate content (58.04 %) and Cowpea (gayan-gayan) has the highest Moisture contents (12.43 %) respectively. Soya bean has the highest contents of vitamin (B1, B3, and B6) for the three water soluble vitamins analysed although the values obtained were less than the recommended dietary allowance recommended by the World Health Organization (WHO). In the Mineral composition of the two species of cowpea beans (Vigna unguiculata), and soybean analysed, soybean had the highest content of most of the mineral elements. The concentration of potassium was found to be very much higher than all the other mineral elements that were determined in all the samples. The results from this analysis shows that the three varieties of beans analyzed were found to be rich in minerals and highly nutritious.Keywords: Vigna unguiculata, Glycine max, vitamins, minerals and proximate composition

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Section: Quantitative Determination Of Water Soluble Vitamins Mineramentioning

confidence: 99%

Quantitative determination of water soluble vitamins, minerals and proximate compositions of three varieties of beans in Bauchi State Nigeria

Mohammed¹,

Matinja²,

Tijjani³

et al. 2019

Glo Jnl Pure Appl Sci

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“…It assists in carbohydrate conversion into glucose and aids in the production of fatty acids and cholesterol. It plays an important role in DNA replication and repair, as well as in cell differentiation; therefore, it is necessary for maintaining proper peripheral nervous system function [133,143].…”

Section: Water-soluble Vitamins Vitamin Bmentioning

confidence: 99%

“…Acetyl-CoA is necessary for the synthesis of the complex fatty-acyl chains of myelin; moreover, it also regulates iron levels, as proper iron levels are also essential for myelin production. Vitamin B5 deficiency is accompanied by peripheral nerve damage [133,143] Vitamin B6 (Pyridoxine, pyridoxamine, and pyridoxal) functions mainly as a coenzyme in the metabolism of amino acids, glycogen, and sphingolipids; in addition, the vitamin B6 complex possesses potent antioxidative characteristics as it effectively quenches reactive oxygen species [144,145]. Vitamin B6 deficiency is a causative factor in the idiopathic carpal tunnel syndrome, and its supplementation has been reported to alleviate the related symptoms as reviewed by Aufiero et al [146].…”

Section: Water-soluble Vitamins Vitamin Bmentioning

confidence: 99%

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The Role of Dietary Nutrients in Peripheral Nerve Regeneration

Soury

Fornasari

Carta

et al. 2021

IJMS

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Peripheral nerves are highly susceptible to injuries induced from everyday activities such as falling or work and sport accidents as well as more severe incidents such as car and motorcycle accidents. Many efforts have been made to improve nerve regeneration, but a satisfactory outcome is still unachieved, highlighting the need for easy to apply supportive strategies for stimulating nerve growth and functional recovery. Recent focus has been made on the effect of the consumed diet and its relation to healthy and well-functioning body systems. Normally, a balanced, healthy daily diet should provide our body with all the needed nutritional elements for maintaining correct function. The health of the central and peripheral nervous system is largely dependent on balanced nutrients supply. While already addressed in many reviews with different focus, we comprehensively review here the possible role of different nutrients in maintaining a healthy peripheral nervous system and their possible role in supporting the process of peripheral nerve regeneration. In fact, many dietary supplements have already demonstrated an important role in peripheral nerve development and regeneration; thus, a tailored dietary plan supplied to a patient following nerve injury could play a non-negotiable role in accelerating and promoting the process of nerve regeneration.

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“…Vitamins of the B group are water-soluble vitamins with many beneficial effects on the nervous system, which deficiency has been linked to different neurodegenerative diseases [ 20 ]. As demyelination and axonal deterioration are common for both vitamin B deficiency and many neurological diseases, including MS, it is believed that vitamin B treatment could aid in axonal recovery and improvement of neuronal function [ 21 , 22 , 23 , 24 ]. In our previously published paper [ 25 ], we have shown that VBC (a complex of vitamins B1, B2, B3, B5, B6, and B12) treatment enhanced the motor nerve regeneration and the recovery of muscle function in a rat model of peripheral nerve injury.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B Complex and Experimental Autoimmune Encephalomyelitis –Attenuation of the Clinical Signs and Gut Microbiota Dysbiosis

et al. 2022

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The present study aimed to investigate the neuroprotective effects of the vitamin B complex (B1, B2, B3, B5, B6, and B12—VBC), by studying the changes in the femoral nerve, quadriceps muscle, popliteal lymph nodes and gut microbiota in the rat model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE). VBC treatment attenuated clinical signs of EAE during the disease, and reduced the duration of EAE thereby contributing to a faster recovery. In VBC-treated EAE rats, a significant decrease in nerve and muscle nuclear density was revealed during the onset period of the disease, while a marked increase was detected at the end of the disease, compared with untreated EAE rats. In the lymph nodes of VBC-treated EAE rats, a fewer number of lymphoid follicles in the cortical area and smaller epithelioid granulomas were detected. The changes in microbiota composition were examined using 16S rRNA gene sequencing and bioinformatics analysis, which revealed the potential of VBC treatment in establishing and/or maintaining gut microbiota homeostasis. Finally, the present study demonstrated that VBC treatment ameliorated the cellular changes in the affected peripheral nerve, muscles innervated by this nerve, and the gut microbiota dysbiosis which occurred during the EAE.

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Vitamin B Complex as a Potential Therapeu Tical Modality in Combating Peripheral Nerve Injury

Cited by 4 publications

References 39 publications

Quantitative determination of water soluble vitamins, minerals and proximate compositions of three varieties of beans in Bauchi State Nigeria

Quantitative determination of water soluble vitamins, minerals and proximate compositions of three varieties of beans in Bauchi State Nigeria

The Role of Dietary Nutrients in Peripheral Nerve Regeneration

Vitamin B Complex and Experimental Autoimmune Encephalomyelitis –Attenuation of the Clinical Signs and Gut Microbiota Dysbiosis

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