Vitamin B-6 Requirements of Elderly Men and Women

Ribaya-Mercado, Judy D.; Russell, Robert M.; Sahyoun, Nadine R.; Morrow, Frank D.; Gershoff, Stanley N.

doi:10.1093/jn/121.7.1062

Cited by 71 publications

(46 citation statements)

References 27 publications

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“…Patients had low hemoglobin concentrations in our study; however, vitamin B6 status revealed no effect on hemoglobin concentration. This finding agrees with that of other studies (Ribaya-Mercado et al, 1991;Huang et al, 1998). Patients had low hemoglobin concentrations which may be caused by other factors.…”

Section: Discussionsupporting

confidence: 93%

“…Tébi et al (2000) reported that 590 diseased elderly people had an adequate mean EAST-AC level (1.75 AE 0.38). However, studies (Lui et al, 1985;Ribaya-Mercado et al, 1991) indicated that EAST-AC could be normal in the presence of chronic and marginal vitamin B6 deficiency. Therefore, EALT-AC rather than EAST-AC is a more sensitive indicator of vitamin B6 status (Brown et al, 1975;Leklem, 1990;Cochary et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

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Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Huang¹,

Ph²,

Chen³

et al. 2002

Eur J Clin Nutr

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Objective: To assess vitamin B6 intake and status of critically ill patients. The relationship between vitamin B6 status indicators and the severity of illness and outcome in these patients was also examined. Design: Prospective clinical study. Setting: The study was performed at the Taichung Veteran General Hospital, in the central part of Taiwan. Subjects: Ninety-four patients in the intensive care unit (ICU) entered the study and 46 patients successfully completed this study. Interventions: No intervention. Main outcome measures: Vitamin B6 intake was recorded for 14 days. Vitamin B6 status was assessed by direct measures (plasma pyridoxal 5 0 -phosphate (PLP), pyridoxal (PL), and urinary 4-pyridoxic acid (4-PA)) and indirect measures (erythrocyte alanine (EALT-AC) and aspartate (EAST-AC) aminotransaminase activity coefficient). The severity of illness (APACHE II score), the length of ventilation dependency, and the length of ICU and hospital stay were recorded. Results: Patients had an adequate mean vitamin B6 intake (16.26 AE 19.39 mg) during the 14 day study. Mean vitamin B6 intake was significantly higher on day 14 than on day 1 (P < 0.001). However, plasma PLP and PL concentrations significantly decreased at the 14th day after admission (P < 0.05). Erythrocyte alanine aminotransaminase activity coefficient and EAST-AC did not change significantly. Urinary 4-PA significantly increased at the 14th day (P < 0.001). No significant relationships were found between APACHE II scores and clinical outcomes (the length of ICU and hospital stay, the length of ventilation dependency) of patients, vitamin B6 intake or status indicators. Conclusions: Critically ill patients received nutritional support in the ICU, and had sufficient mean vitamin B6 intake and adequate vitamin B6 status. Therefore, the severity of illness and the results should not be affected by vitamin B6 status. However, we have noted that plasma PLP and PL concentrations significantly decreased while vitamin B6 intake significantly increased on day 14. Critical clinical conditions and complex metabolism in the critically ill may account for the reduction of plasma PLP and PL. Since vitamin B6 deficiency causes profound effects on immune system function, dietary or supplemented vitamin B6 intake is suggested for hospitalized patients.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Huang¹,

Ph²,

Chen³

et al. 2002

Eur J Clin Nutr

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“…Plasma PLP concentration in elderly adults aged 65-75 y was lower than that in young adults aged 25-35 y, while dietary vitamin B6 intake and urinary 4-PIC were the same among these groups (24), consistent with the present results for age-related alteration of vitamin B6 metabolism obtained from the animal experiment. The vitamin B6 requirements of the elderly over 60 y were determined as 1.9-2.0 mg/d from their plasma PLP and urinary 4-PIC (25), and these values are higher than those reported for younger adults (26). An oral vitamin B6 loading study shows that vitamin B6 absorption and ability to synthesize PLP are not different between elderly and young adult (24).…”

Section: Discussionmentioning

confidence: 83%

Age-Related Alterations of B-Group Vitamin Contents in Urine, Blood and Liver from Rats

Fukuwatari

Wada

Shibata

2008

J Nutr Sci Vitaminol

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SummaryTo investigate how aging alters B-group vitamin metabolism, rats were fed with niacin-free 20% casein diet from 3 to 80 wk old, and the urinary excretions of the B group vitamins were periodically measured. The blood and liver B-group vitamin levels in 80-wk-old rats were also compared with those in 8-wk-old rats. The urinary excretion of thiamin, riboflavin, vitamin B 6 metabolite 4-pyridoxic acid, pantothenic acid, folic acid and biotin were not altered during 540 d. The urinary vitamin B 12 increased by 8-fold at 29 wk old, and further increased at 80 wk old. Conversion of nicotinamide from tryptophan gradually decreased to 60% from 29 to 48 wk old. Plasma PLP, vitamin B 12 and folate levels in 80-wk-old rats were lower than those in 8-wk-old rats, consistent with lower liver vitamin B 6 and folate levels in aged rats. Plasma and liver biotin levels in aged rats were higher than those in young rats. Other B-group vitamins such as vitamin B 1 , vitamin B 2 , niacin and pantothenic acid levels in blood and liver from aged rats were same as those from young rats. Alteration of vitamin B 6 metabolism in particular is similar to the observations in eldery humans reported previously. Our findings suggest that aged rats can be useful models to investigate aging-related B-group vitamin metabolism. Key Words aging, vitamin B 2 , vitamin B 6 , folate, biomarker The precise cascade of pathological age-related events is still not clearly understood, but enhanced production of free radicals and its deleterious effects on macro-biomolecules such as proteins and DNA ( 1 , 2 ) as well as polyunsaturated fatty acids ( 3 ) are well known during aging. Aging is a major risk factor for various chronic disorders including cancer. It is well known that taking in nutrients suitable for life stages is important to prevent the aging process and chronic disorders. Food, namely nutrient intake, is a key factor affecting aging and the incidence of many chronic disorders ( 4 -6 ). Decreased food intake and a sedentary lifestyle reduce energy expenditure and may alter their metabolism in elderly adults, and alteration of metabolism may cause alteration of nutrient requirement. However, there is not sufficient information on how aging alters vitamin metabolism ( 7 , 8 ). To investigate age-related alterations of B-group vitamins, rats were kept for 540 d from 3 to 80 wk old, and the urinary excretions of the B group vitamins were periodically measured. The blood and liver B-group vitamin levels in 80-wk-old rats were also compared with those in 8-wk-old rats.

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“…Decrease in apoenzyme synthesis or in crease in apoenzyme degradation, and im pairment of PLP-binding sites have been pre viously suspected to explain preserved a-EAST values in chronic vitamin B6 deficiency [16]. Plasma PLP has been reported to be the most appropriate single index to use for nutri tional status surveys of elderly persons be cause a-EAST can appear normal in the pres ence of chronic and marginal vitamin B6 defi ciency [17][18][19], For vitamin C, plasma ascor bate values were always lower in subjects with infection as compared with both of the other groups.…”

Section: Discussionmentioning

confidence: 99%

Vitamin B<sub>6</sub> and Vitamin C Status in Elderly Patients with Infections during Hospitalization

Pfitzenmeyer

Guilland²,

d'Athis³

1997

Ann Nutr Metab

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We have evaluated whether vitamin B₆ and C metabolism may be altered by infection in the elderly. Vitamin B₆ and C biochemical status has been assessed for times over a period of 21 days (days 0, 7, 14, and 21) in 18 subjects ≧75 years. The subjects were divided into 3 groups: group I (8 subjects with acute infection), group II (4 malnourished subjects), and group III (6 control subjects). Vitamin B₆ status was determined by plasma pyridoxal-5’-phosphate (PLP) and erythrocyte aspartate aminotransferase activation coefficient (α-EAST), and vitamin C status by plasma ascorbic acid. During the 3 weeks, vitamins Be and C values were significantly different between groups: at days 7 and 14, PLP values were significantly higher in group III than in both groups I and II, and α-EAST values were significantly higher in group I than in both groups II and III. Plasma ascorbate values were significantly lower in group I than in both groups II and III. These data suggest that an acute catabolic state like infection may influence vitamin B₆ and C metabolism. Nevertheless, more work is needed to assert that vitamin B₆ and C supplementation may be useful during infection.

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Vitamin B-6 Requirements of Elderly Men and Women

Cited by 71 publications

References 27 publications

Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Vitamin B6 intakes and status of mechanically ventilated critically ill patients in Taiwan

Age-Related Alterations of B-Group Vitamin Contents in Urine, Blood and Liver from Rats

Vitamin B<sub>6</sub> and Vitamin C Status in Elderly Patients with Infections during Hospitalization

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