Vitamin B 12 and folate metabolism.

Shinton, N. K.

doi:10.1136/bmj.1.5799.556

Cited by 21 publications

(19 citation statements)

References 15 publications

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“…1B-D). These results clearly showed that urinary excretion of vitamin B 12 was dependent uponurine volume, but not on intake of vitamin B 12 .Vitamin B 12 is different from other B-group vitamins with respect to main excretion route, which is through the bile, and <10% of the total loss of vitamin B 12 from the body is through urine (Shinton, 1972). These results suggest that the change in the level of urinary vitamin B 12 is too small to evaluate intake of vitamin B 12 , and thus urinary vitamin B 12 was unavailable to be used as biomarker for estimation of its intake.…”

Section: Factors Affecting the Urinary Excretion Of Water-soluble Vitmentioning

confidence: 75%

Urinary Water-Soluble Vitamins as Nutritional Biomarker to Estimate Their Intakes

Fukuwatari¹,

Shibata²

2012

Biomarker

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Section: Factors Affecting the Urinary Excretion Of Water-soluble Vitmentioning

confidence: 75%

Urinary Water-Soluble Vitamins as Nutritional Biomarker to Estimate Their Intakes

Fukuwatari¹,

Shibata²

2012

Biomarker

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“…The urinary excretion levels of vitamin B12 do not reflect the intake or the nutritional status of vitamin B12 (6). Vitamin B12 is different from other water-soluble vitamins with respect to its mechanism of absorption and main excretion route-the main excretion route is thought to be the bile (39). Available reports suggest that plasma concentrations of vitamin B12, methylmalonic acid, and total homocysteine are effective biomarkers of a change in vitamin B12 intake (40).…”

Section: Vitamin B12mentioning

confidence: 99%

Urinary Excretion Levels of Water-Soluble Vitamins in Pregnant and Lactating Women in Japan

Shibata

Fukuwatari

Sasaki

et al. 2013

J Nutr Sci Vitaminol

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Dietary habits of pregnant and lactating women have a critical impact on the health of future infants. For this reason, the Japanese Dietary Reference Intakes regarding the amounts of addition of water-soluble vitamins have been set (1). The additional intake amounts for pregnant and lactating women were calculated based on data concerning the changes in the metabolic characteristics of vitamins in pregnant women and the loss of vitamins as a result of lactation. However, there is little information about whether nutritional statuses of water-soluble-vitamins in Japanese pregnant and lactating women are good or not. Therefore, we examined the nutritional status of pregnant and lactating women and speculated about the validity of the additional amount of some water-soluble vitamins in the dietary reference intakes for pregnant and lactating women.A potential approach for determining the validity for the additional amounts is based on the observation that a water-soluble vitamin or its catabolite(s) can be detected in the urine (2-11). Using this approach, the urinary excretion of a water-soluble vitamin or its catabolite(s) occurs when the dietary intake exceeds an individual necessary amount. MATERIALS AND METHODSSubjects. Japanese pregnant (16-40 wk gestation) or lactating women (0-11 mo postpartum) were recruited from a parenting circle in The University of Shiga Prefecture between April 2010 and February 2012. Japanese married non-pregnant, non-lactating women also were recruited as controls through the parenting circle to match the mean ages and heights of the pregnant and lactating women. The purpose and protocol of this study was explained to all participants before joining the study, and written informed consent was obtained from each participant. We excluded participants diagnosed with a cold or influenza, and those who had taken multi-vitamin supplements at least once during the previous month. In addition, we excluded participants whose 24-h urine collection was considered incomplete: a collection time outside the 22-26-h range, urine volume ,250 mL, or extremely low or high energy intake (,500 or .4,000 kcal/d) (12). Twenty-four of the 2nd trimester pregnant (16-27 wk gestation) and 32 of the Bunkyo-ku, Tokyo 113-0033, Japan (Received December 17, 2012) Summary Recent studies have shown that the urinary excretion levels of water-soluble vitamins can be used as biomarkers for the nutritional status of these vitamins. To determine changes in the urinary excretion levels of water-soluble vitamins during pregnant and lactating stages, we surveyed and compared levels of nine water-soluble vitamins in control (non-pregnant and non-lactating women), pregnant and lactating women. Control women (n537), women in the 2nd (16-27 wk, n524) and 3rd trimester of pregnancy (over 28 wk, n532), and early-(0-5 mo, n554) and late-stage lactating (6-11 mo, n549) women took part in the survey. The mean age of subjects was ~30 y, and mean height was ~160 cm. A single 24-h urine sample was collected 1 d after the comple...

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“…43 Folate plays a role as a methyl donor for S-adenosylmethionine 44 and may thus influence DNA methylation. Methylation is also required for the synthesis of thymidine monophosphate from deoxyuridine monophosphate, thereby preventing the incorporation of uracil in DNA and preventing point mutations, single and double stranded DNA breaks, chromosome breakage and micronucleus formation.…”

Section: The Role Of Folic Acid In the Development Of Asthmamentioning

confidence: 99%

The genomic origins of asthma

Sharma

Chhabra

Kho

et al. 2014

Thorax

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Lung function tracks from the earliest age that it can be reliably measured. Genome wide association studies (GWAS) suggest that most variants identified for common complex traits are both regulatory in function and active during fetal development. Fetal programming of gene expression during development is critical to the formation of a normal lung. An understanding of how fetal developmental genes related to diseases of the lungs and airways is a critical area for research. This review article will consider the developmental origins hypothesis, the stages of normal lung development and a variety of environmental exposures that might influence the developmental process: in utero cigarette smoke exposure, vitamin D and Folate. We conclude with some information on developmental genes and asthma.

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Vitamin B 12 and folate metabolism.

Cited by 21 publications

References 15 publications

Urinary Water-Soluble Vitamins as Nutritional Biomarker to Estimate Their Intakes

Urinary Water-Soluble Vitamins as Nutritional Biomarker to Estimate Their Intakes

Urinary Excretion Levels of Water-Soluble Vitamins in Pregnant and Lactating Women in Japan

The genomic origins of asthma

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