Vitamin and Carotenoid Status in Older Women: Associations With the Frailty Syndrome

Michelon, Elisabete; Blaum, Caroline S.; Semba, Richard D.; Qin, Xue; Ricks, Michelle O.; Fried, Linda P.

doi:10.1093/gerona/61.6.600

Cited by 133 publications

(107 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A significant association between vitamin B12 deficiency and incident disability and the frailty syndrome (Matteini et al, 2008) was reported in two studies. However, two other studies failed to demonstrate an association between vitamin B12 and frailty (Michelon et al, 2006;Semba et al, 2006). The latter findings were supported by the current results.…”

Section: Discussionsupporting

confidence: 90%

Homocysteine and the risk of nursing home admission and mortality in older persons

et al. 2011

View full text Add to dashboard Cite

Background/Objectives: This study aimed to investigate whether higher homocysteine and lower vitamin B12 concentrations increase the risk of future nursing home (NH) admission and all-cause mortality in independently living older persons. Subjects/Methods: In total, 1117 independently living participants (mean age ¼ 75.1, s.d. ¼ 6.4) were included in this prospective sub-study of the Longitudinal Aging Study Amsterdam. EDTA plasma samples, collected in 1995-1996, were analysed for total homocysteine (mmol/l). Time to NH admission was assessed using a follow-up until [2002][2003]. In addition, we studied mortality until 1 June 2007. Cox proportional hazards models were used to examine the association between homocysteine in quartiles and risk of NH admission and mortality. Results: During follow-up, 126 persons (11.3%) were admitted to NHs, and 513 persons (45.9%) deceased. In men, no significant associations were observed. In women, after adjustment for confounding, the highest quartile of homocysteine was associated with a significantly higher risk of NH admission compared with the first quartile (hazard ratio (HR) ¼ 2.97, 95% confidence interval (CI) ¼ 1.36-6.49). Both women in the third and the fourth quartile of homocysteine had a significantly higher mortality risk (HR ¼ 1.70, 95% CI ¼ 1.08-2.65 and HR ¼ 1.91, 95% CI ¼ 1.22-3.00, respectively) compared with the first quartile. Vitamin B12 was not related to an increased risk of NH admission and mortality. Conclusions: Elevated plasma homocysteine is associated with an increased risk of NH admission and mortality in older women, but not in older men.

show abstract

Section: Discussionsupporting

confidence: 90%

Homocysteine and the risk of nursing home admission and mortality in older persons

et al. 2011

View full text Add to dashboard Cite

show abstract

“…These findings suggest that those with limited resources are less likely to drive or be driven to their main food shopping venue and are less likely to choose higher-fibre foods such as fruit, vegetables and whole grains, possibly because of higher cost and/or challenges related to carrying these food items. The consumption of adequate fruit, vegetables and wholegrain foods is imperative to preventing malnutrition in older adults, as there is growing evidence that the low intakes of micronutrients found in these foods, such as vitamins C and E, carotenoids and folate, are significantly associated with increased risk of frailty in older adults (31)(32)(33) .…”

Section: Discussionmentioning

confidence: 99%

Food shopping habits, physical activity and health-related indicators among adults aged ≥70 years

Thompson

Bentley

Davis

et al. 2011

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To investigate the food shopping habits of older adults in the UK and explore their potential associations with selected health-related indicators. Design: A cross-sectional study including objectively measured physical activity levels, BMI, physical function and self-reported health status and dietary intake. Setting: Bristol, UK. Subjects: A total of 240 older adults aged $70 years living independently. Results: Mean age was 78?1 (SD 5?7) years; 66?7 % were overweight or obese and 4 % were underweight. Most (80?0 %) carried out their own food shopping; 53?3 % shopped at least once weekly. Women were more likely to shop alone (P , 0?001) and men more likely to shop with their spouse (P , 0?001). Men were more likely than women to drive to food shopping (P , 0?001), with women more likely to take the bus or be driven (P , 0?001). Most reported ease in purchasing fruit and vegetables (72?9 %) and low-fat products (67?5 %); 19?2 % reported low fibre intakes and 16?2 % reported high fat intakes. Higher levels of physical function and physical activity and better general health were significantly correlated with the ease of purchasing fresh fruit, vegetables and low-fat products. Shopping more often was associated with higher fat intake (P 5 0?03); higher levels of deprivation were associated with lower fibre intake (P 5 0?019). Conclusions: These findings suggest a pattern of food shopping carried out primarily by car at least once weekly at large supermarket chains, with most finding high-quality fruit, vegetables and low-fat products easily accessible. Higher levels of physical function and physical activity and better self-reported health are important in supporting food shopping and maintaining independence. Older adults comprise the fastest-growing population group, with WHO projecting a total of 1?2 billion people over the age of 60 years by 2025 (1) . In 2001, there were approximately 1 million adults aged $85 years in England and Wales, with this number projected to increase to 2?5 million (or 4 % of the total population) by 2031 (2) . In these countries there has been a 14-fold and 23-fold increase in the number of male and female centenarians, respectively, over the past 50 years of the 20th century (3) . This substantial increase in the number of older adults has important implications for individuals, families and health-and social-care systems, as there is the potential for many people to live a greater number of years in poor health.Older adults are at greatest risk for lifestyle-related diseases, including type 2 diabetes, CHD, stroke, hypertension and certain cancers. In the UK, 41 % of men and 38 % of women aged 60-74 years suffer from a chronic illness that limits daily activities; this increases to 58 % of men and 62 % of women over the age of 75 years (4) . Interventions incorporating healthy eating and regular physical activity are known to be effective in reducing the risks of several chronic diseases (5,6) , emphasising the significant contribution of these lifestyle factor...

show abstract

“…Buna karfl›n B12'nin patogenezde rol oynayabilece¤ini gösteren veriler de mevcuttur (1,19). Baflka bir çal›flmada ise, B6 vitamini ile iliflki gösterilmifltir (26). En güçlü iliflki total karotenoidler, beta-karoten ve lutein/Zeaxanthin ile bulunmufltur (1,19).…”

unclassified

“…D vitamini etki mekanizmas›nda; hiperparatiroidi ve artm›fl sitokin seviyeleri ve ba¤lant›l› olarak sarkopenin etkili olabilece¤i belirtilmektedir (1,16,22). Düflük 25 OH D seviyeleri, asl›nda tüm bu iliflkiler göz önüne al›nd›¤›nda beklenece¤i üzere, düflme, k›r›k, a¤r›, sarkopeni, kötü fiziksel fonksiyon, özürlülük ve k›r›lganl›k ile iliflkili bulunmufltur (26,27). ‹lginç flekilde bir çal›flmada, D vitamini yetersizli¤inin k›r›lganl›k ile iliflkisi sadece erkeklerde saptanm›flt›r (16).…”

unclassified

“…Düflük düzeyleri; azalm›fl el s›kma gücü, kalça fleksiyonu, diz ekstansiyonu ve azalm›fl yürüme h›z› ile iliflkili bulunmufltur. Ancak, karotenoid verilmesi ile fiziksel performansta iyileflme olabilece¤i ile ilgili çal›flmalar henüz yap›lmam›flt›r (1,26). B B1 12 2 V Vi it ta am mi in ni i: : B12 vitamininde azalma, azalm›fl enerji metabolizmas›na neden olup k›r›lganl›kta rol oynayabilir.…”

unclassified

See 1 more Smart Citation

Approach to the Frail Elderly

Kutsal¹

2010

tftr

View full text Add to dashboard Cite

Ö Öz ze et tK›r›lgan yafll› sendromu, geriatrik sendromlardan biri olup, oluflan strese artm›fl hassasiyet olarak tan›mlanmakta ve birbiri ile iliflkili pek çok sistemde bozulma ile seyretmektedir. Yayg›n semptom ve bulgular›; istemsiz kilo kayb›, kas güçsüzlü¤ü, yorgunluk, yürüme h›z›nda azalma ve fonksiyonlarda ilerleyici kay›pt›r. K›r›lgan yafll›n›n tedavi yönetimi en zorlu tablolardan birisidir. Tedavi edici yaklafl›mlar; nutrisyonel destek, uygun egzersiz program›, çok yönlü geriatrik de¤erlendirme yan›nda konsültasyonla tedavi planlanmas› ve hormonal veya anti-inflamatuvar yaklafl›mlard›r. K›r›lgan yafll›da bu tedavilerin etkinli¤ini ve potansiyel zararlar›n› ortaya koyacak ileri çal›flmalara gereksinim vard›r. Türk Fiz T›p Rehab Derg 2010;56:135-40. A An na ah ht ta ar r K Ke el li im me el le er r: : K›r›lgan yafll›, tedavi S Su um mm ma ar ry y Frail elderly syndrome is a geriatric syndrome of increased vulnerability to stressors due to impairments in multiple interrelated systems. Common signs and symptoms are unintentional weight loss, muscle weakness, fatigue, slow walking speed, and progressive functional decline. Frail older adults are among the most challenging for medical management. Therapeutic interventions include nutritional supplementation, exercise training, comprehensive geriatric assessment and management by consultation services, and hormonal or antiinflammatory interventions. Further intervention studies are needed to determine the effectiveness and the potential harm of these treatment modalities in the frail elderly. G Gi ir ri ifl flK›r›lgan yafll› sendromu, ileri yafltaki kiflilerde s›k görülmesine ra¤men yeni yeni isim bulmaya ve araflt›rmalarda giderek artan bir ilgi görmeye bafllam›flt›r. Çünkü k›r›lganl›k, yafll› kiflilerde ek hastal›klar›n ve mortalitenin temel belirleyicisi olarak tan›mlanmaktad›r (1,2). Altm›fl befl yafl üstü kiflilerin %7'sinde, 80 yafl üstü kiflilerin ise %30-40'›nda bu sendroma rastlanmaktad›r (3). Pek çok sistemde bozulma ile giden bu tablo, oluflan strese artm›fl hassasiyet olarak tan›mlanmaktad›r (4-6). K›r›lgan yafll›lar›n, hastal›klara, immobiliteye, düflmelere, özürlülü¤e, hastaneye yat›fla ba¤l› olarak ortaya ç›kan strese dayan›kl›l›klar› daha azd›r (4). Kad›nlarda erkeklere oranla daha s›k görülmektedir. Cinsiyetler aras›ndaki bu farkl›l›¤›n nedeni henüz bilinmemektedir (1).

show abstract

Vitamin and Carotenoid Status in Older Women: Associations With the Frailty Syndrome

Cited by 133 publications

References 29 publications

Homocysteine and the risk of nursing home admission and mortality in older persons

Homocysteine and the risk of nursing home admission and mortality in older persons

Food shopping habits, physical activity and health-related indicators among adults aged ≥70 years

Approach to the Frail Elderly

Contact Info

Product

Resources

About