Vitamin A nutritional status in high- and low-income postpartum women and its effect on colostrum and the requirements of the term newborn

Gurgel, Cristiane Santos Sânzio; Grilo, Evellyn Câmara; Lira, Larissa Queiroz de; Assunção, Débora Gabriela Fernandes; Oliveira, Priscila Gomes de; Melo, Larisse Rayanne Miranda de; Medeiros, Silvia V. de; Pessanha, Luanna C.; Dimenstein, Roberto; Lyra, Clélia de Oliveira

doi:10.1016/j.jped.2017.08.003

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…The highest prevalence of low VA levels in children under 5 years was found in the Northeast (19.0%) and Southeast (21.6%) regions of the country, although there were no statistical differences between macroregions when evaluating women . In the Brazilian Northeast context, many studies have reported a high probability of this kind of deficiency occurring among women attending public hospitals in this region, which suggests that DVA can result in serious prejudice for the health of women and their babies in the intiial days after childbirth. Faced with these circumstances, it is important that studies assess the VA status of populations at risk of developing VAD, such as those in the Brazilian Northeast.…”

Section: Introductionmentioning

confidence: 99%

Retinol status and associated factors in mother–newborn pairs

Bezerra

Ribeiro

Lima

et al. 2019

J Human Nutrition Diet

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Background Vitamin A deficiency is still considered to be a nutritional problem during pregnancy, lactation and early childhood. The present study aimed to assess the vitamin A status of women and their newborns in the Brazilian Northeast and to determine the association between retinol in the maternal serum, umbilical cord blood and colostrum. Methods Vitamin A status in 65 pairs of women and newborns was assessed from samples of the mother’s serum, umbilical cord serum and colostrum using high‐performance liquid chromatography. The inadequacy of the vitamin A status of mothers and infants was identified if the retinol values were <0.7 µmol L−1 in maternal serum or umbilical cord blood or <1.05 µmol L−1 in colostrum. Results The prevalence of inadequate maternal vitamin A status was 21.5% (95% CI: 11.5%–31.5%) and 13.8% [95% confidence interval (CI) = 5.4%–22.2%] based on maternal serum and colostrum, respectively. Among newborns, 41.5% (95% CI = 29.3%–53.5%) presented a low status of vitamin A based on cord serum. Multiple linear regression analysis identified that maternal serum retinol is a predictor of umbilical cord retinol (P = 0.005). Retinol in maternal serum was lower in mothers who were less educated (P = 0.04) and colostrum retinol was higher in older (P = 0.04) and multiparous (P = 0.002) mothers. Conclusions Vitamin A deficiency is a common problem among mothers attended in public hospitals in Northeast Brazil and maternal retinol concentrations are associated with retinol status in newborns. Maternal age, parity and educational level were related to the maternal vitamin A status.

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Section: Introductionmentioning

confidence: 99%

Retinol status and associated factors in mother–newborn pairs

Bezerra

Ribeiro

Lima

et al. 2019

J Human Nutrition Diet

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“…It was found that VA intakes, serum, and colostrum VA were elevated in the high-income level, with use of multivitamins during pregnancy emerging as a significant predictor of these outcomes. For high compared with low income, mean maternal intakes during pregnancy were 872 ± 639 and 1169 ± 695 µg RAE/d, which corresponded to colostrum VA concentrations of 86.7 ± 40.0 and 108 ± 58.6 µg/dL, respectively ( 64 ). In a hospital-based randomized controlled trial (RCT) of single-dose oral VAS administered soon after delivery, significantly fewer supplemented mothers, compared with nonsupplemented mothers, had deficient concentrations of breastmilk retinol (<0.7 µmol/L).…”

Section: Resultsmentioning

confidence: 99%

Vitamin A Requirements in Pregnancy and Lactation

Gannon

Jones

Mehta

2020

Current Developments in Nutrition

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Pregnancy and lactation are critical life stages with unique nutritional requirements, including for vitamin A (VA). Current Dietary Reference Intakes (DRIs) for VA were published in 2001. The objective of this review was to identify and categorize evidence related to VA requirements in pregnancy and lactation since these DRIs were formulated. We searched MEDLINE and included articles according to an analytic framework of maternal VA exposure on status and health outcomes in the mother-child dyad. Intermediate and indirect evidence supports that maternal VA intakes can impact the mother's VA status, breastmilk, and health outcomes, as well as the child's VA status and select health outcomes. Food-based approaches may lead to more sustained, sufficient VA status in mothers and children. Research needs include further study linking maternal VA intakes on maternal and child VA status, and further associations with outcomes to determine intake requirements to optimize health.

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“…Studies reported on vitamin A in lactating women are limited and predominantly from developing countries [27][28][29][30][31][32]. In our study, the plasma retinol concentration was 1.39 µmol/L in women 6-wk postpartum, similar to that for Brazilian women who were measured immediately or within 48 h after a delivery (1.39-1.70 µmol/L), but much higher than those for women in the Ethiopia (0.71 µmol/L) [27] or South Africa (1.03 µmol/L) [32].…”

Section: Discussionmentioning

confidence: 99%

Geographic and socio-demographic determinants of plasma retinol concentrations in Chinese pregnant and lactating women

Zhou

et al. 2021

Eur J Nutr

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Purpose To examine plasma retinol status and its determinants in Chinese pregnant or lactating women. Methods A cross-sectional study involving 1211 healthy women in mid-pregnancy, late pregnancy, or lactation was conducted in northern, central, and southern China. Plasma retinol concentration was determined by high-performance liquid chromatography. Multivariate quantile regression or modified Poisson regression was used to estimate adjusted medians, or to examine the associations of suboptimal retinol concentration (< 1.05 µmol/L) with various factors. ResultsThe overall median (interquartile range) retinol concentration was 1.25 (1.06-1.46) µmol/L. The adjusted concentration was higher in women at lactation (1.39 [1.20-1.63] µmol/L) and mid-pregnancy (1.26 [1.10-1.44] µmol/L) than late pregnancy (1.07 [0.92-1.28] µmol/L), and higher in women in the central area (1.34 [1.18-1.49] µmol/L) and the north (1.26 [1.10-1.43] µmol/L) than the south (1.19 [1.07-1.31] µmol/L). The retinol concentration was more likely to be low in women with lower pre-pregnancy BMI, younger age, less education, and in lactating women who had a caesarean birth or were breastfeeding exclusively. A total of 290 (24.0%) women had a suboptimal retinol concentration, and the prevalence was higher in women at late pregnancy, residing in the south, with younger age, and having underweight pre-pregnancy. Conclusion About one-fourth of pregnant or lactating women in China had suboptimal retinol concentrations that varied with phases of pregnancy and lactation, region of residence, and socio-demographic characteristics, indicating a need for population-specific public health strategies to optimize vitamin A status.

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Vitamin A nutritional status in high- and low-income postpartum women and its effect on colostrum and the requirements of the term newborn

Abstract: Serum vitamin A deficiency was considered a mild public health problem in both populations; however, newborns of low-income women were more likely to receive lower retinol levels through colostrum when compared with newborns of high-income mothers.

Cited by 6 publications

References 19 publications

Retinol status and associated factors in mother–newborn pairs

Retinol status and associated factors in mother–newborn pairs

Vitamin A Requirements in Pregnancy and Lactation

Geographic and socio-demographic determinants of plasma retinol concentrations in Chinese pregnant and lactating women

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