Vitamin A in pregnancy and lactation

Bates, Christopher J.

doi:10.1079/pns19830008

Cited by 56 publications

(30 citation statements)

References 68 publications

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“…Severe deficiency of VA results in infertility, or impairs reproduction, mostly due to fetal resorption, stillbirths, and congenital malformations (Bates, 1983;Clagett-Dame and DeLuca, 2002). VA deficiency is also associated with an increased risk of preterm delivery and maternal anemia (Radhika et al, 2002), as well as abnormal placental apoptosis (Antipatis et al, 2002).…”

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confidence: 98%

Retinoic acid‐metabolizing enzyme cytochrome P450 26a1 (cyp26a1) is essential for implantation: Functional study of its role in early pregnancy

Han

Xia

Sun

et al. 2010

Journal Cellular Physiology

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Vitamin A (VA) is required for normal fetal development and successful pregnancy. Excessive VA intake during pregnancy may lead to adverse maternal and fetal effects. Cytochrome P450 26A1 (cyp26a1), a retinoic acid (RA)-metabolizing enzyme, is involved in VA metabolism. It has been shown that cyp26a1 is expressed in female reproductive tract, especially in uterus. In order to investigate the role of cyp26a1 during pregnancy, we constructed a recombinant plasmid DNA vaccine encoding cyp26a1 protein and immunized mice with the plasmid. Compared to control groups, the pregnancy rate of the cyp26a1 plasmid-immunized mice were significantly decreased (P < 0.01). Further results showed that both cyp26a1 mRNA and protein were specifically induced in the uterus during implantation period and localized in the uterine luminal epithelium. Importantly, the number of implantation sites was also significantly reduced (P < 0.05) after the uterine injection of cyp26a1-specific antisense oligos or anti-cyp26a1 antibody on day 3 of pregnancy. Accordingly, the expression of RA-related cellular retinoic acid binding protein 1 and tissue transglutaminase was markedly increased (P < 0.05) in the uterine luminal epithelium after intrauterine injection treatments. These data demonstrate that uterine cyp26a1 activity is important for the maintenance of pregnancy, especially during the process of blastocyst implantation.

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confidence: 98%

Retinoic acid‐metabolizing enzyme cytochrome P450 26a1 (cyp26a1) is essential for implantation: Functional study of its role in early pregnancy

Han

Xia

Sun

et al. 2010

Journal Cellular Physiology

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“…In the Gambia, mango and palm oil were identi®ed as critical foods in maintaining carotenoid A intakes and were used to augment diets during pregnancy and lactation (Bates, 1983). The use of burriti sweets (Mauritia vinifera) as part of a vitamin A supplementation, intervention programme for children was implemented in Brazil (Mariath et al 1989).…”

Section: Intervention Studiesmentioning

confidence: 99%

Value of traditional foods in meeting macro- and micronutrient needs: the wild plant connection

2000

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The importance of edible wild plants may be traced to antiquity but systematic studies are recent. Anthropologists, botanists, ecologists, food scientists, geographers, nutritionists, physicians and sociologists have investigated cultural aspects and nutrient composition of edible species. Important contributions to the diet from edible wild plants are well documented and numerous studies reveal roles played by`lesser-known' species when meeting macro-and micronutrient needs of groups at risk, whether infants and children, pregnant and/or lactating women, or the elderly. The literature is vast and scattered but information on the macroand micronutrient content of wild plants and their importance to the human diet appear in ®ve kinds of publications: cultural works by social scientists, descriptions and inventories by botanists, dietary assessment studies by nutritionists, intervention programmes managed by epidemiologists and physicians, and composition data generally conducted by food scientists and chemists. Many macro-and micronutrient-dense wild species deserve greater attention but lack of adequate nutrient databases, whether by region or nation, limit educational efforts to improve diets in many Third World areas. Limited and uneven compositional data generally re¯ect factors of cost and personal interest in key nutrients. Whilst edible wild plants are regularly deprecated by policy makers and considered to be the`weeds of agriculture', it would be tragic if this led to loss of ability to identify and consume these important available species. Ethnobotany: Macronutrients: Micronutrients: Nutritional anthropology: Wild plantsAs there is a plenty of common and French sorrel; lamb's quarters, and water cresses, growing about camp; and as these vegetables are very conducive to health, and tend to prevent the scurvy and all putrid disorders . . . the General recommends to the soldiers the constant use of them, as they make an agreeable salad, and have the most salutary effect. The regimental of®cer of the day [is] to send to gather them every morning, and have them distributed among the men.'Washington (1777)

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“…However its level during pregnancy is significantly higher in vitamin supplemented group (Villard and Bates, 1987) and decreases during pregnancy and reaches to those of non-pregnant women at postpartum period (Bates, 1983;Willingford and Underwood, 1986;Panth et al, 1990). The immunoglobulin studies have shown low concentrations in children with low intake of vitamin-A (Vobecky et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

Determination of Serum Vitamin-A, β-carotene, Total Proteins and Fractions in Women Within 24 Hours of Delivery from Different Age and Socioeconomic Groups

Tabassum¹,

Javed²,

Abbas³

et al. 1997

Pakistan J. of Biological Sciences

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Serum studies in 90 randomly selected lactating women of three socioeconomic (low, middle and high) and age (below 25, 26-32 and above 33 years) groups of Faisalabad, Pakistan, revealed an overall concentration of β-carotene and vitamin-A to be 170.12±88.64 and 54.72±22.69 mg/100 mL, respectively. The β-carotene and vitamin-A showed non-significant difference between socioeconomic and age groups, however, β-carotene was relatively higher in young women and those belonging to higher socioeconomic group, whereas vitamin-A was relatively higher in old women and those belonging to meddle socioeconomic group. The serum total proteins, albumin, globulins and A:G ratio during present study was 5.48±1.24 g/100 mL, 2.82±1.27 g mLG 1 , 2.68±1.44 g mLG 1 and 1.66±1.78 g/100 mL, respectively, The total proteins and albumin showed non-significant difference between socioeconomic and age groups while globulins and A:G ratio revealed higher (p<0.05) values in high and middle socioeconomic groups, respectively.

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Vitamin A in pregnancy and lactation

Cited by 56 publications

References 68 publications

Retinoic acid‐metabolizing enzyme cytochrome P450 26a1 (cyp26a1) is essential for implantation: Functional study of its role in early pregnancy

Retinoic acid‐metabolizing enzyme cytochrome P450 26a1 (cyp26a1) is essential for implantation: Functional study of its role in early pregnancy

Value of traditional foods in meeting macro- and micronutrient needs: the wild plant connection

Determination of Serum Vitamin-A, β-carotene, Total Proteins and Fractions in Women Within 24 Hours of Delivery from Different Age and Socioeconomic Groups

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