Vitamin A deficiency disturbs collagen IV and laminin composition and decreases matrix metalloproteinase concentrations in rat lung. Partial reversibility by retinoic acid

Esteban-Pretel, Guillermo; Marín, M. Luisa; Renau‐Piqueras, Jaime; Sado, Yoshikazu; Barber, Teresa; Timoneda, Joaquín

doi:10.1016/j.jnutbio.2012.03.010

Cited by 13 publications

(16 citation statements)

References 55 publications

(74 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The examination of the literature data regarding the correlations between antioxidants and MMPs profile shows controversial aspects. In fact, MMP-9 plasma levels are negatively associated with provitamin A carotenoids in a general population [47] while, in experimental models, the deficiency of vitamin A seems to be responsible for a gelatinase decrease without any variations of TIMPs [48]. In subjects with acute stroke the infusion of uric acid induced a decrease of total and active MMP-9 levels [49] and the treatment with antioxidants (polyethylene glycol-superoxide dismutase and N-acetyl-L-cysteine) reduces the MMP-9 activity in plasma and in aortic tissue homogenates of experimental models of diabetes mellitus [39] and the use of tempol (a ROS scavenger) reduces MMP-2 levels and its activity in aortic rings of animal models of renovascular hypertension [50].…”

Section: Discussionmentioning

confidence: 99%

“…Even in experimental models of oxidative stress (obtained with the depletion of glutathione), taurine inhibits MMP-2 activation in cardiac tissues [51]. Differently, the treatment with retinoic acid increases significantly MMP-9 but not MMP-2 [48] and lutein, a carotenoid, enhances MMP-9 synthesis in animal models [52]. Therefore, all these studies do not clarify how in subjects with MS the TAS could be positively related to the gelatinases and their tissue inhibitors and then all these data need further investigation.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Hopps

Presti

Montana

et al. 2014

Mediators of Inflammation

View full text Add to dashboard Cite

Our aim was to examine some parameters of oxidative status, gelatinases, and their inhibitors and to evaluate their interrelationships in subjects with metabolic syndrome (MS). We enrolled 65 MS subjects, subdivided according to the presence or not of diabetes mellitus. We examined lipid peroxidation (expressed as thiobarbituric acid reacting substances, TBARS), protein oxidation (expressed as carbonyl groups), nitric oxide metabolites (NOx), total antioxidant status (TAS), MMP-2, MMP-9, TIMP-1, and TIMP-2. We found that MS subjects, diabetics and nondiabetics, showed an increase in TBARS, PC, and NOx. A significant decrease in TAS was observed only in nondiabetic MS subjects in comparison with diabetic MS subjects. We observed increased concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2, higher in diabetic subjects. Our data showed a positive correlation between TAS and MMP-2, TAS and MMP-9, and TAS and MMP-9/TIMP-1 and a negative correlation between TBARS and MMP-2 in diabetic MS subjects in the entire group. In MS subjects a prooxidant status and increased levels of gelatinases and their inhibitors are evident although the correlations between oxidative stress and MMPs or TIMPs are controversial and need further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Hopps

Presti

Montana

et al. 2014

Mediators of Inflammation

View full text Add to dashboard Cite

show abstract

“…All these modifications in the chains of both collagen IV and laminin correlated with those in their corresponding mRNAs. MMP2 and MMP9, which degrade some BM macromolecules and, hence, are important contributors to the BM structure and composition, were decreased in the absence of retinoids, but two of their physiological inhibitors, TIMP1 and TIMP2, were not modified [ 141 ]. Therefore in VAD, BM degrading capacity may be diminished, which contributes to the BM alteration observed.…”

Section: Vitamin a Deficiency And Alterations In Extracellular Matmentioning

confidence: 99%

Vitamin A Deficiency and Alterations in the Extracellular Matrix

et al. 2014

Self Cite

View full text Add to dashboard Cite

Vitamin A or retinol which is the natural precursor of several biologically active metabolites can be considered the most multifunctional vitamin in mammals. Its deficiency is currently, along with protein malnutrition, the most serious and common nutritional disorder worldwide. It is necessary for normal embryonic development and postnatal tissue homeostasis, and exerts important effects on cell proliferation, differentiation and apoptosis. These actions are produced mainly by regulating the expression of a variety of proteins through transcriptional and non-transcriptional mechanisms. Extracellular matrix proteins are among those whose synthesis is known to be modulated by vitamin A. Retinoic acid, the main biologically active form of vitamin A, influences the expression of collagens, laminins, entactin, fibronectin, elastin and proteoglycans, which are the major components of the extracellular matrix. Consequently, the structure and macromolecular composition of this extracellular compartment is profoundly altered as a result of vitamin A deficiency. As cell behavior, differentiation and apoptosis, and tissue mechanics are influenced by the extracellular matrix, its modifications potentially compromise organ function and may lead to disease. This review focuses on the effects of lack of vitamin A in the extracellular matrix of several organs and discusses possible molecular mechanisms and pathologic implications.

show abstract

“…Therefore, we analyzed whether the BrPSp and BrWEt extracts from Brassica hairy roots might affect the expression of collagen type IV and laminin genes. Figure A shows that BrWEt induced a marked increase (about 350%) of collagen IV gene expression in keratinocytes, an increase even higher than that produced by retinoic acid, used as positive control . Conversely, BrPSp extract did not induce any significant effect on collagen IV expression (data not shown).…”

Section: Resultsmentioning

confidence: 87%

Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution

Sena¹,

Zappelli²,

Apone³

et al. 2017

J of Cosmetic Dermatology

View full text Add to dashboard Cite

show abstract

Vitamin A deficiency disturbs collagen IV and laminin composition and decreases matrix metalloproteinase concentrations in rat lung. Partial reversibility by retinoic acid

Cited by 13 publications

References 55 publications

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome

Vitamin A Deficiency and Alterations in the Extracellular Matrix

Brassica rapa hairy root extracts promote skin depigmentation by modulating melanin production and distribution

Contact Info

Product

Resources

About