Vital Staining of Growing Bones and Teeth with Alizarine Red S

Schour, Isaac; Hoffman, Mallory; Sarnat, Bernard G.; Engel, Milton B.

doi:10.1177/00220345410200050301

Cited by 49 publications

(9 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At Illinois, Preissecker's and Cimasoni and Beck's descriptive histological analysis was replaced by a thorough and systematic approach using morphometric statistics and vital-dye-staining techniques that had been introduced decades earlier at the same University by fellow faculty members. (68,69) As a consequence, their measurements focused on the remodeling of tissues such as alveolar Chicago studies confirms that the studies undertaken were a direct reflection of Chicago's intellectual environment and the techniques available at the University of Illinois at that time. As faithful gatekeepers of Sicher and Weinmann's intellectual heritage, Schneider and Meyer's investigation was driven by a search for answers to Sicher and Weinmann's questions about the role of form and function in the evolution of the dentition.…”

Section: Question 2: Movement Of Teeth: Mechanical Displacement or Timentioning

confidence: 83%

Vienna–Chicago: The cultural transformation of the model system of the un‐opposed molar

Diekwisch

2007

BioEssays

View full text Add to dashboard Cite

The discussion over the roles of genes and environment on the phenotypical specification of organisms has held a central role in science philosophy since the late 19(th) century and has re-emerged in today's debate over genetic determinism and developmental plasticity. In fin-de-siecle Vienna, this debate coincided with a philosophical debate over empiricism/materialism versus idealism/vitalism. Turn-of-the-century Vienna's highly interdisciplinary environment was also the birthplace for the model system of the un-opposed molar. The un-opposed molar system features new tissue formation at the roots of teeth and tooth drift once opposing teeth are lost. The un-opposed molar model system was revived by a group of Viennese scientists who left Vienna during the Nazi period to address Vienna's questions about evolution and heredity and about genes and environment in Chicago's post-WWII scientific exile community. Here we are using the colorful history of the un-opposed molar to investigate the role of culture and method in the scientific evolution of a model system.

show abstract

Section: Question 2: Movement Of Teeth: Mechanical Displacement or Timentioning

confidence: 83%

Vienna–Chicago: The cultural transformation of the model system of the un‐opposed molar

Diekwisch

2007

BioEssays

View full text Add to dashboard Cite

show abstract

“…Dentin Apposition Rate The vital staining method (5) was used for measuring the amount of dentin apposition. Alizarin Red S was injected intraperitoneally, 100 mgm.…”

Section: Ziskin Gibbon Skarka and Bellowsmentioning

confidence: 99%

Effects of Large Daily Doses of Vitamin D on Teeeth and Jaws of Rats and on Humans

et al. 1943

View full text Add to dashboard Cite

The purpose of this study was to determine the effect of massive daily doses of vitamin D2 on dentin apposition, bone apposition, tooth eruption, calcification rhythm, skeletal calcification, pulp stone formation, estrus cycle, and toxicity in rats, and pulp stone formation in humans. [Experiments in the treatment of rheumatoid arthritis with massive daily doses of vitamin D have been conducted by a number of investigators (1).]Schour and Ham (2) reported the effect on the calcification of the incisor dentin of the rat from the administration of a single large dose of vitamin D. Schour and Hoffman (3), in a study of dentin calcification rhythm, reported that severe experimental interferences such as hypophysectomy or parathyroidectomy did not alter the calcification rhythm. Weinmann (4) studied calcification and pulp stone formation by histological section. The methods employed in the present study differed from those used in the aforementioned. To the best of our knowledge, the literature does not report a comparable experiment. ANIMAL EXPERIMENTSThirty-two female, white rats of the Sherman strain, aged 57 to 59 days at the beginning of the experiment, were observed. Twelve served as an untreated group, while 20 were treated experimentally. There were 4 sets of litter-mates, 4 animals to each set, distributed between the untreated and treated groups in equal numbers. The study was set up so as to provide 2 sets of controls; namely, the untreated group of animals, and a control period in each animal. A control period of 2 weeks was followed by an experimental period of 2 weeks. In this way, a safe margin was allowed for the time required for the incisor of the rat to renew itself. Only 4 animals were placed in a cage, thus giving each a better opportunity to obtain ample food. The animals were earmarked and weighed, and each cage was provided with a regular stock diet.3

show abstract

“…This technique followed naturally from the experiments of du Hamel (1739-43), of Hunter (1798), and of Macklin (1917), and was further elaborated by Brash (1924Brash ( , 1926 and by Proell (1926). Schour (1936), Schour & Hoffman (1938), Schour, Hoffman, Sarnat & Engel (1941), and most workers since, have used sodium sulphalizarate (1-2-dihydroxy-3-sodium sulphonic anthraquinone)-apparently identical with the sodium alizarin sulphonate used by Gottlieb in 1914. They gave it in a 2 % solution in 0-45 % sodium chloride by intraperitoneal injection, and reported that single doses of the order of 100 mg./kg.…”

Section: Introductionmentioning

confidence: 99%

Alizarin as an indicator of bone growth

1953

American Journal of Orthodontics

View full text Add to dashboard Cite

Vital Staining of Growing Bones and Teeth with Alizarine Red S

Cited by 49 publications

References 16 publications

Vienna–Chicago: The cultural transformation of the model system of the un‐opposed molar

Vienna–Chicago: The cultural transformation of the model system of the un‐opposed molar

Effects of Large Daily Doses of Vitamin D on Teeeth and Jaws of Rats and on Humans

Alizarin as an indicator of bone growth

Contact Info

Product

Resources

About