Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells

Jung, Kyung Oh; Youn, Hyewon; Lee, Chulhee; Kang, Keon Wook; Chung, June‐Key

doi:10.18632/oncotarget.14247

Cited by 119 publications

(100 citation statements)

References 31 publications

(30 reference statements)

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“…For example, a significant increase in the exosomal miRNA‐210 of hypoxic breast cancer cells was observed both in vitro and in vivo. Uptake of hypoxic miRNA‐210‐enriched exosomes by ECs was demonstrated to upregulate vascular remodeling‐related genes, such as PTP1B and Ephrin A3, and to enhance angiogenesis …”

Section: Exosomes In Hypoxia Conditionsmentioning

confidence: 99%

How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

et al. 2020

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Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and quality of exosomes, and review the mechanisms by which hypoxic cell‐derived exosomes regulate ischemic cell behaviors in both cancerous and noncancerous cells.

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Section: Exosomes In Hypoxia Conditionsmentioning

confidence: 99%

How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

et al. 2020

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“…Niemoeller et al () analysed miRNA expression levels of six malignant cancer cell lines after radiotherapy and showed that, among others, miRNA‐210, −31, and − 378 are over‐expressed. In addition, miRNA‐210‐containing exosomes establish a cross‐talk between primary cancer cells and neighbouring metastatic cells promoting tumour progression, EMT, and MET regulation, while miRNA‐31‐containing exosomes regulate reprogramming efficiency through mitochondrial metabolism (Bigagli et al , ; Jung et al , ). Interestingly, Pinweha et al () showed that miRNA‐210, −31, and − 378 inhibit SDH and/or FH expression (Table ), strongly supporting a causal link between oncometabolites and tumour repopulation.…”

Section: Oncometabolites and Tumour Repopulationmentioning

confidence: 99%

Oncometabolites in cancer aggressiveness and tumour repopulation

et al. 2019

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Tumour repopulation is recognized as a crucial event in tumour relapse where therapy-sensitive dying cancer cells influence the tumour microenvironment to sustain therapy-resistant cancer cell growth. Recent studies highlight the role of the oncometabolites succinate, fumarate, and 2-hydroxyglutarate in the aggressiveness of cancer cells and in the worsening of the patient's clinical outcome. These oncometabolites can be produced and secreted by cancer and/or surrounding cells, modifying the tumour microenvironment and sustaining an invasive neoplastic phenotype. In this review, we report recent findings concerning the role in cancer development of succinate, fumarate, and 2-hydroxyglutarate and the regulation of their related enzymes succinate dehydrogenase, fumarate hydratase, and isocitrate dehydrogenase. We propose that oncometabolites are crucially involved in tumour repopulation. The study of the mechanisms underlying the relationship between oncometabolites and tumour repopulation is fundamental for identifying efficient anti-cancer therapeutic strategies and novel serum biomarkers in order to overcome cancer relapse.

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“…Exosomes that were directly labeled with Cy7 administered iv and imaged using IVIS spectrum showed a tendency to accumulate mainly in the tumor tissue and intestine. Analysis of mouse serum also indicated systemic circulation of exosomes containing miR-210 (Jung et al, 2017). Exosomes derived from mesenchymal stem cells (MSCs) have the potential for therapy of injured tissue, as they preserve some of the therapeutic characteristics and factors of their parent cells (R. C. Lai et al, 2013).…”

Section: Optical Imagingmentioning

confidence: 99%

Advances in imaging strategies for in vivo tracking of exosomes

Betzer

Barnoy

Sadan

et al. 2019

WIREs Nanomed Nanobiotechnol

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Exosomes have many biological functions as short‐ and long distance nanocarriers for cell‐to‐cell communication. They allow the exchange of complex information between cells, and thereby modulate various processes such as homeostasis, immune response and angiogenesis, in both physiological and pathological conditions. In addition, due to their unique abilities of migration, targeting, and selective internalization into specific cells, they are promising delivery vectors. As such, they provide a potentially new field in diagnostics and treatment, and may serve as an alternative to cell‐based therapeutic approaches. However, a major drawback for translating exosome treatment to the clinic is that current understanding of these endogenous vesicles is insufficient, especially in regards to their in vivo behavior. Tracking exosomes in vivo can provide important knowledge regarding their biodistribution, migration abilities, toxicity, biological role, communication capabilities, and mechanism of action. Therefore, the development of efficient, sensitive and biocompatible exosome labeling and imaging techniques is highly desired. Recent studies have developed different methods for exosome labeling and imaging, which have allowed for in vivo investigation of their bio‐distribution, physiological functions, migration, and targeting mechanisms. These improved imaging capabilities are expected to greatly advance exosome‐based nanomedicine applications. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology

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Visualization of exosome-mediated miR-210 transfer from hypoxic tumor cells

Cited by 119 publications

References 31 publications

How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

Oncometabolites in cancer aggressiveness and tumour repopulation

Advances in imaging strategies for in vivo tracking of exosomes

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