How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

Yaghoubi, Sajad; Najminejad, Hamid; Dabaghian, Mehran; Karimi, Mohammad Hossein; Abdollahpour‐Alitappeh, Meghdad; Rad, Fariba; Mahi-Birjand, Motahareh; Mohammadi, Shiva; Mohseni, Fatemeh; Lari, Mohammad Sobhani; Teymouri, Gholam Hossein; Yousofabadi, Esmat Rigi; Salmani, Abbas; Bagheri, Nader

doi:10.1002/iub.2275

Cited by 36 publications

(26 citation statements)

References 76 publications

(162 reference statements)

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“…Tissue injury and ongoing cellular hypoxia contribute to release of procoagulant EVs. 46 Supporting this, we found that patients with severe injury characteristics had the highest early EV-associated procoagulant activity after trauma. Appropriate resuscitation of trauma patients helps to restore deranged physiology and improves cellular hypoxia, 47 and presumably diminishes EV release as normal homeostasis is reestablished.…”

Section: Discussionsupporting

confidence: 72%

Extracellular vesicle–associated procoagulant activity is highest the first 3 hours after trauma and thereafter declines substantially: A prospective observational pilot study

Rognes

Hellum

Ottestad

et al. 2021

J Trauma Acute Care Surg

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Section: Discussionsupporting

confidence: 72%

Extracellular vesicle–associated procoagulant activity is highest the first 3 hours after trauma and thereafter declines substantially: A prospective observational pilot study

Rognes

Hellum

Ottestad

et al. 2021

J Trauma Acute Care Surg

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“…The hypoxia‐driven effects on EV production and their downstream functions were recently reviewed by Yaghoubi et al. (2020). We will focus our review on technical aspects of EV research and functions of hypoxic EVs (hypo‐EVs) in comparison to normoxic EVs (normo‐EVs).…”

Section: Introductionmentioning

confidence: 99%

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

Bister

Pistono

Huremagic

et al. 2020

J of Extracellular Vesicle

107

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Hypoxia is an essential hallmark of several serious diseases such as cardiovascular and metabolic disorders and cancer. A decline in the tissue oxygen level induces hypoxic responses in cells which strive to adapt to the changed conditions. A failure to adapt to prolonged or severe hypoxia can trigger cell death. While some cell types, such as neurons, are highly vulnerable to hypoxia, cancer cells take advantage of a hypoxic environment to undergo tumour growth, angiogenesis and metastasis. Hypoxia‐induced processes trigger complex intercellular communication and there are now indications that extracellular vesicles (EVs) play a fundamental role in these processes. Recent developments in EV isolation and characterization methodology have increased the awareness of the importance of EV purity in functional and cargo studies. Cell death, a hallmark of severe hypoxia, is a known source of intracellular contaminants in isolated EVs. In this review, methodological aspects of studies investigating hypoxia‐induced EVs are critically evaluated. Key concerns and gaps in the current knowledge are highlighted and future directions for studies are set. To accelerate and advance research, an in‐depth analysis of the functions and cargo of hypoxic EVs, compared to normoxic EVs, is provided with the focus on the altered microRNA contents of the EVs.

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“…As a hallmark of solid tumors, hypoxia is an imbalance between increased oxygen demand and oxygen supply inadequate, which is associated with high proliferative rates [22]. Previously, numerous studies reported that hypoxic phenotypes in solid tumors caused various biological processes, including malignant metastasis, angiogenesis, metabolic alteration, and inducing resistance to treatment [23][24][25]. These ndings support that hypoxia has prognostic value and can be a therapeutic target for tumors.…”

Section: Discussionmentioning

confidence: 86%

A hypoxia-related gene pairs signature for predicting overall survival in lung adenocarcinoma

Zhang

2021

Preprint

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Background: Increasing evidence has depicted the clinical importance of the correlation between hypoxia and immune status in lung adenocarcinoma environment (LUAD). However, the reliable prognostic signatures based on the interaction of hypoxia and immune status are still limited. Therefore, we strived to construct a hypoxia-immune-related gene pairs signature for risk assessment and stratification for patients with LUAD.Methods: Gene expression profiles and clinical data of patients with lung adenocarcinoma were acquired from two public data sets, used as training and validation cohorts respectively. Different bioinformatics and statistical methods were applied to construct a robust hypoxia-related gene pairs (HRGPs) signatures for predicting overall survival in lung adenocarcinoma. Furthermore, we explored the correlation between HRGPs signature and infiltrating immune cells using the CIBERSORT algorithm in LUAD samples.Results: Among 146 hypoxia-related genes, a 13 HRGPs signature was built that was significantly associated with OS in the training cohort (P<0.01). In the validation cohort, the HRGPs signature stratified patients into high- and low-risk groups with a significant OS difference (P=0.04). After adjusting the other clinical factors, the developed HRGPs signature remained independent in multivariate analysis. Plasma cells and NK cells resting were significantly correlated with the OS of patients with LUAD. Functional analysis showed that the high-risk group was enriched in terms of DNA replication, lymphocyte apoptotic process, and cell cycle-related pathways.Conclusion: The HRGPs signature represents a promising risk model for patient’s stratification in LUAD. It might provide new insights into clinical decision-making regarding individualized treatment.

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How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

Cited by 36 publications

References 76 publications

Extracellular vesicle–associated procoagulant activity is highest the first 3 hours after trauma and thereafter declines substantially: A prospective observational pilot study

Extracellular vesicle–associated procoagulant activity is highest the first 3 hours after trauma and thereafter declines substantially: A prospective observational pilot study

Hypoxia and extracellular vesicles: A review on methods, vesicular cargo and functions

A hypoxia-related gene pairs signature for predicting overall survival in lung adenocarcinoma

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