2020
DOI: 10.1002/iub.2275
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How hypoxia regulate exosomes in ischemic diseases and cancer microenvironment?

Abstract: Exosomes, as natural occurring vesicles, play highly important roles in the behavior and fate of ischemic diseases and different tumors. Secretion, composition, and function of exosomes are remarkably influenced by hypoxia in ischemic diseases and tumor microenvironment. Exosomes secreted from hypoxic cells affect development, growth, angiogenesis, and progression in ischemic diseases and tumors through a variety of signaling pathways. In this review article, we discuss how hypoxia affects the quantity and qua… Show more

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Cited by 39 publications
(30 citation statements)
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References 76 publications
(162 reference statements)
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“…Tissue injury and ongoing cellular hypoxia contribute to release of procoagulant EVs. 46 Supporting this, we found that patients with severe injury characteristics had the highest early EV-associated procoagulant activity after trauma. Appropriate resuscitation of trauma patients helps to restore deranged physiology and improves cellular hypoxia, 47 and presumably diminishes EV release as normal homeostasis is reestablished.…”
Section: Discussionsupporting
confidence: 72%
“…Tissue injury and ongoing cellular hypoxia contribute to release of procoagulant EVs. 46 Supporting this, we found that patients with severe injury characteristics had the highest early EV-associated procoagulant activity after trauma. Appropriate resuscitation of trauma patients helps to restore deranged physiology and improves cellular hypoxia, 47 and presumably diminishes EV release as normal homeostasis is reestablished.…”
Section: Discussionsupporting
confidence: 72%
“…The hypoxia‐driven effects on EV production and their downstream functions were recently reviewed by Yaghoubi et al. (2020). We will focus our review on technical aspects of EV research and functions of hypoxic EVs (hypo‐EVs) in comparison to normoxic EVs (normo‐EVs).…”
Section: Introductionmentioning
confidence: 99%
“…As a hallmark of solid tumors, hypoxia is an imbalance between increased oxygen demand and oxygen supply inadequate, which is associated with high proliferative rates [22]. Previously, numerous studies reported that hypoxic phenotypes in solid tumors caused various biological processes, including malignant metastasis, angiogenesis, metabolic alteration, and inducing resistance to treatment [23][24][25]. These ndings support that hypoxia has prognostic value and can be a therapeutic target for tumors.…”
Section: Discussionmentioning
confidence: 86%