Visualization of blood drainage area from hypervascular hepatocellular carcinoma on ultrasonographic images during hepatic arteriogram: Comparison with depiction of drainage area on contrast‐enhanced ultrasound

Kita, Ryuichi; Sakamoto, Azusa; Nagata, Yoshiaki; Nishijima, Norihiro; Ikeda, Atsuyuki; Matsuo, Hiroo; Okada, M; Ashida, Shinji; Taniguchi, Toshikatsu; Kimura, Tōru; Osaki, Yukio

doi:10.1111/j.1872-034x.2012.01019.x

Cited by 14 publications

(6 citation statements)

References 19 publications

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“…Also, metastatic satellite nodules and local recurrences after resection or ablation frequently develop in the corona enhancement areas (63). To more effectively treat such metastases and reduce the risk of recurrence, some authors have recommended that the corona enhancement areas be included within the surgical resection margin or ablation zone (63,125).…”

Section: Ancillary Features That Favor the Diagnosis Of Malignancy Bumentioning

confidence: 99%

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Choi¹,

Lee²,

Sirlin³

2014

Radiology

455

385

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Computed tomography (CT) and magnetic resonance (MR) imaging play critical roles in the diagnosis and staging of hepatocellular carcinoma (HCC). The second article of this two-part review discusses basic concepts of diagnosis and staging, reviews the diagnostic performance of CT and MR imaging with extracellular contrast agents and of MR imaging with hepatobiliary contrast agents, and examines in depth the major and ancillary imaging features used in the diagnosis and characterization of HCC.q RSNA, 2014

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Section: Ancillary Features That Favor the Diagnosis Of Malignancy Bumentioning

confidence: 99%

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Choi¹,

Lee²,

Sirlin³

2014

Radiology

455

385

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“…There are five imaging techniques for evaluations of tumor blood outflow: single-level dynamic CTHA [ 29 , 30 ], biphasic CTHA [ 31 ], contrast sonography with perfluorobutane microbubbles [ 32 ], intravenous dynamic contrast enhanced CT, and intravenous dynamic contrast enhanced MR imaging [ 26 , 33 , 34 ]. Single-level dynamic CTHA, the first technique which demonstrated the tumor blood outflow ever, is the principal technique kinetically depicting both inflow and outflow at one time with the highest temporal resolution.…”

Section: Tumor Blood Outflows and Hepatocarcinogenesismentioning

confidence: 99%

Tumor Hemodynamics and Hepatocarcinogenesis: Radio-Pathological Correlations and Outcomes of Carcinogenic Hepatocyte Nodules

et al. 2014

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Tumor hemodynamics of carcinogenic hepatocytes nodules, that is, low grade dysplastic nodules, high grade dysplastic nodules, early hepatocellular carcinomas (HCCs), and progressed HCCs, change during multistep dedifferentiation of the nodules. Morphometric analyses of inflow vessels of these nodules indicate that the portal veins of carcinogenic hepatocyte nodules monotonically decrease whereas the arteries bitonically change, first decrease and then increase. Findings on imaging techniques depicting these changes in tumor blood inflows, especially intra-arterial contrast-enhanced computed tomography, closely related not only to the histological differentiation of the nodules but also to the outcomes of the nodules. Histological analyses of connections between the vessels within the tumors and those in the surrounding livers and findings on imaging techniques indicate that drainage vessels of HCC change from hepatic veins to hepatic sinusoids and then to portal veins during multistep hepatocarcinogenesis. Understanding of tumor hemodynamics through radio-pathological correlations will be helpful in drawing up therapeutic strategies for carcinogenic hepatocyte nodules arising in cirrhosis.

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“…IA-CEUS can display the blood supply of the tumour more directly via arterial catheter. Moreover, HA-CEUS can eliminate the interference of peripheral tissue enhancement and display the wash-out direction of the tumour better to evaluate the distribution of the wash-out blood around the tumour, which may predict the possibility of recurrence or metastasis around the tumour [ 20 ]. In addition, since arteries can be selected, HA-CEUS shows only the arterial blood supply, while SMA-CEUS shows only the portal vein blood supply, which may avoid interference between the arterial and portal phases in peripheral vein CEUS [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…It can be performed via different injection methods, including arterial and peripheral venous routes. Intraarterial contrast-enhanced ultrasound (IA-CEUS) can be performed intraprocedurally via catheters inserted into feeder arteries to observe the arterial supply more selectively and directly than possible via veins, without interference from the surrounding tissues [ 20 ]. IA-CEUS has been used to guide TACE and provide information on necrosis [ 21 ], but has not been studied with respect to TR prediction.…”

Section: Introductionmentioning

confidence: 99%

Intraarterial contrast-enhanced ultrasound to predict the short-term tumour response of hepatocellular carcinoma to Transarterial chemoembolization with Lipiodol

et al. 2021

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Background Transarterial chemoembolization (TACE) is an effective locoregional therapy in hepatocellular carcinoma (HCC). However, it is difficult to predict the tumour response (TR) of TACE intraprocedurally. The aim of this study was to predict the TR after TACE (1–3 months) in HCC patients using intraprocedural intraarterial contrast enhanced ultrasound (IA-CEUS). Methods In this case-control study, consecutive patients who received TACE in our hospital from September 2018 to May 2019 were enrolled. IA-CEUS was performed before and after TACE. Postoperative contrast-enhanced liver MRI was performed 1–3 months after TACE as the gold standard. According to the modified Response Evaluation Criteria in Solid Tumours (mRECIST), ultrasonic manifestations were compared between the complete remission (CR) group and non-CR group by univariate and multivariate analyses. A logistic predictive model was established and validated, and its diagnostic efficiency was evaluated. Results Forty-four patients with sixty-one lesions were enrolled in the study. Multivariate analysis identified, the risk factors as a large lesion diameter (OR: 1.84; 95% confidence interval [CI]: 1.009, 3.080; P = 0.020), a larger dimension of non-enhancing area in superior mesenteric artery (SMA)-CEUS than the size in B-mode ultrasound preoperatively (OR: 3.379; 95% CI: 1.346,8.484; P = 0.010), presence of corona enhancement in hepatic artery (HA)-CEUS postoperatively (OR: 6.642; 95% CI: 1.214, 36.331; P = 0.029), and decreased corona enhancement thickness (per centimetre) postoperatively (OR: 0.025; 95% CI: 0.006,0.718; P = 0.025). The area under the receiver operating characteristic curve (AUROC) of the predictive model was 0.904 (95% CI: 0.804, 0.966; P < 0.001). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 81.08, 91.67, 85.25, 93.75, and 75.86%, respectively. Leave-one-out cross-validation (LOOCV) showed that the accuracy was 77.05%. Conclusions Intraprocedural IA-CEUS can be used to predict the TR in HCC patients after TACE.

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Visualization of blood drainage area from hypervascular hepatocellular carcinoma on ultrasonographic images during hepatic arteriogram: Comparison with depiction of drainage area on contrast‐enhanced ultrasound

Abstract: Corona enhancement could be visualized even on US images, and the average thickness of them was 6 mm.

Cited by 14 publications

References 19 publications

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

CT and MR Imaging Diagnosis and Staging of Hepatocellular Carcinoma: Part II. Extracellular Agents, Hepatobiliary Agents, and Ancillary Imaging Features

Tumor Hemodynamics and Hepatocarcinogenesis: Radio-Pathological Correlations and Outcomes of Carcinogenic Hepatocyte Nodules

Intraarterial contrast-enhanced ultrasound to predict the short-term tumour response of hepatocellular carcinoma to Transarterial chemoembolization with Lipiodol

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