Visualization of Anterior Chamber Angle Structures With Scattering- and Polarization-Sensitive Anterior Segment Optical Coherence Tomography

Ueno, Yuta; Mori, Hideki; Kikuchi, Keita; Yamanari, Masahiro; Oshika, Tetsuro

doi:10.1167/tvst.10.14.29

Cited by 10 publications

(14 citation statements)

References 41 publications

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“…A previous polarization-sensitive OCT study revealed artifactual linear structures that appeared to be scleral vessels 18 . The presence of low-intensity band artifacts in OCT images of the sclera has also been reported 19 , 20 . To our knowledge, available retinal commercial OCT systems are polarization-dependent; thus, birefringence-derived artifacts might exist in commercial OCT images of the sclera 20 .…”

Section: Introductionmentioning

confidence: 64%

“…Moreover, low-intensity band artifacts were observed in polarization-dependent OCT images but not in commercial OCT images. These findings suggested that birefringence-derived artifacts were partially resolved by using commercial OCT. To our knowledge, available retinal commercial OCT systems do not use polarization-diversity detection; they detect a polarization component that is identical to the polarization state of the reference beam 20 . Birefringence-derived artifacts can occur in both commercial OCT images and polarization-dependent OCT images.…”

Section: Discussionmentioning

confidence: 99%

“…Birefringence-derived artifacts can occur in both commercial OCT images and polarization-dependent OCT images. In commercial OCT images, the influence of birefringence-derived artifacts can be reduced by adjusting a polarization controller in the reference arm of the interferometer, thereby maximizing signal intensity 20 . In contrast, the PD-OCT hardware does not have this reference polarization optimization mechanism for several reasons 23 .…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, available retinal commercial OCT systems are polarization-dependent; thus, birefringence-derived artifacts might exist in commercial OCT images of the sclera 20 . These artifactual structures can easily be distinguished from real scleral structures using datasets of polarization-diversity OCT (PD-OCT) images 18 – 20 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Birefringence-derived scleral artifacts in optical coherence tomography images of eyes with pathologic myopia

Miura

Makita

Yasuno

et al. 2022

Sci Rep

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We investigated birefringence-derived scleral artifacts in optical coherence tomography (OCT) images of eyes with pathologic myopia. This study included 76 eyes of 42 patients with pathologic myopia. Five sets of OCT B-scan images of the macula were obtained using commercial swept-source OCT. A dataset of prototype swept-source polarization-diversity OCT images was used to identify polarization-dependent OCT images (i.e., complex averaging of OCT signals from two polarization channels) and polarization-independent OCT images (i.e., intensity averaging of two OCT signals). Polarization-dependent OCT images and commercial OCT images were assessed for the presence of birefringence-derived artifacts by comparison with polarization-independent OCT images. Both polarization-dependent OCT images and commercial OCT images contained scleral vessel artifacts. Scleral vessel artifacts were present in 46 of 76 eyes (60.5%) imaged by polarization-dependent OCT and 17 of 76 eyes (22.4%) imaged by commercial OCT. The proportion of images that showed scleral vessel artifacts was significantly greater among polarization-dependent OCT images than among commercial OCT images (P < 0.001). Additionally, polarization-dependent OCT images showed low-intensity band artifacts. This study demonstrated the existence of birefringence-derived scleral artifacts in commercial OCT images and indicated that polarization-diversity OCT is an effective tool to evaluate the presence of these artifacts.

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Section: Introductionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Birefringence-derived scleral artifacts in optical coherence tomography images of eyes with pathologic myopia

Miura

Makita

Yasuno

et al. 2022

Sci Rep

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“…Initial PS-OCT schemes were based on TD-OCT. However, PS is now employed in both SS-OCT and SD-OCT to image various ocular structures such as the macula and peripheral retina [ 21 , 64 , 65 ]. A challenge in recognizing AMD early is detecting drusen; PS-OCT can be used to segment the RPE and identify drusen [ 66 ].…”

Section: Polarization-sensitive (Ps) Octmentioning

confidence: 99%

Advances in Optical Coherence Tomography Imaging Technology and Techniques for Choroidal and Retinal Disorders

Ong

Zarnegar

Corradetti

et al. 2022

JCM

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Optical coherence tomography (OCT) imaging has played a pivotal role in the field of retina. This light-based, non-invasive imaging modality provides high-quality, cross-sectional analysis of the retina and has revolutionized the diagnosis and management of retinal and choroidal diseases. Since its introduction in the early 1990s, OCT technology has continued to advance to provide quicker acquisition times and higher resolution. In this manuscript, we discuss some of the most recent advances in OCT technology and techniques for choroidal and retinal diseases. The emerging innovations discussed include wide-field OCT, adaptive optics OCT, polarization sensitive OCT, full-field OCT, hand-held OCT, intraoperative OCT, at-home OCT, and more. The applications of these rising OCT systems and techniques will allow for a closer monitoring of chorioretinal diseases and treatment response, more robust analysis in basic science research, and further insights into surgical management. In addition, these innovations to optimize visualization of the choroid and retina offer a promising future for advancing our understanding of the pathophysiology of chorioretinal diseases.

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Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

Ohno-Matsui,

Igarashi-Yokoi,

Azuma

et al. 2024

JAMA Ophthalmol

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ImportanceThe relevance of visualizing scleral fiber orientation may offer insights into the pathogenesis of pathologic myopia, including dome-shaped maculopathy (DSM).ObjectiveTo investigate the orientation and density of scleral collagen fibers in highly myopic eyes with and without DSM by polarization-sensitive optical coherence tomography (PS-OCT).Design, Setting, and ParticipantsThis case series included patients with highly myopic eyes (defined as a refractive error ≥6 diopters or an axial length ≥26.5 mm) with and without a DSM examined at a single site in May and June 2019. Analysis was performed from September 2019 to October 2023.ExposuresThe PS-OCT was used to study the birefringence and optic axis of the scleral collagen fibers.Main Outcomes and MeasuresThe orientation and optic axis of scleral fibers in inner and outer layers of highly myopic eyes were assessed, and the results were compared between eyes with and without a DSM.ResultsA total of 72 patients (51 [70.8%] female; mean [SD] age, 61.5 [12.8] years) were included, and 89 highly myopic eyes were examined (mean [SD] axial length, 30.4 [1.7] mm); 52 (58.4%) did not have a DSM and 37 (41.6%) had a DSM (10 bidirectional [27.0%] and 27 horizontal [73.0%]). Among the 52 eyes without DSM, the 13 eyes with simple high myopia had primarily inner sclera visible, displaying radially oriented fibers in optic axis images. In contrast, the entire thickness of the sclera was visible in 39 eyes with pathologic myopia. In these eyes, the optic axis images showed vertically oriented fibers within the outer sclera. Eyes presenting with both horizontal and bidirectional DSMs had clusters of fibers with low birefringence at the site of the DSM. In the optic axis images, horizontally or obliquely oriented scleral fibers were aggregated in the inner layer at the DSM. The vertical fibers located posterior to the inner fiber aggregation were not thickened and appeared thin compared with the surrounding areas.Conclusions and RelevanceThis study using PS-OCT revealed inner scleral fiber aggregation without outer scleral thickening at the site of the DSM in highly myopic eyes. Given the common occurrence of scleral pathologies, such as DSM, and staphylomas in eyes with pathologic myopia, recognizing these fiber patterns could be important. These insights may be relevant to developing targeted therapies to address scleral abnormalities early and, thus, mitigate potential damage to the overlying neural tissue.

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Visualization of Anterior Chamber Angle Structures With Scattering- and Polarization-Sensitive Anterior Segment Optical Coherence Tomography

Cited by 10 publications

References 41 publications

Birefringence-derived scleral artifacts in optical coherence tomography images of eyes with pathologic myopia

Birefringence-derived scleral artifacts in optical coherence tomography images of eyes with pathologic myopia

Advances in Optical Coherence Tomography Imaging Technology and Techniques for Choroidal and Retinal Disorders

Polarization-Sensitive OCT Imaging of Scleral Abnormalities in Eyes With High Myopia and Dome-Shaped Macula

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