Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode

Veraart, Claude; Raftopoulos, Christian; Mortimer, J.T.; Delbeke, Jean; Pins, Delphine; Michaux, G.; Vanlierde, Annick; Parrini, Simone; Wanet-Defalque, Marie-Chantal

doi:10.1016/s0006-8993(98)00977-9

Cited by 373 publications

(268 citation statements)

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“…When the eccentricity tends toward 1, the ellipse gets a more elongated shape and can be related to a hash mark or a rectangle. Phosphenes in the form of elongated shapes [22,25] and lines or bars [25,26] have also been observed.…”

Section: Resultsmentioning

confidence: 92%

“…Phosphenes have been observed in the form of doughnut shapes [8], punctuate spots of light when occurring close to the center of the visual field [18,19], elongated shapes [22,25], lines/ bars [25,26], triangles [26], and more complicated patterns [26]. Phosphenes are commonly described as "round" spots of light [8-10, 15, 25, 27] and carrying some colors, such as red [26], blue [8,23,26], yellow [8,23,26], orange [8,18,26] and multicolor [26].…”

Section: Introductionmentioning

confidence: 99%

“…Phosphenes are commonly described as "round" spots of light [8-10, 15, 25, 27] and carrying some colors, such as red [26], blue [8,23,26], yellow [8,23,26], orange [8,18,26] and multicolor [26].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

DL¹,

Wh²

2017

IJCNE

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Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

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A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

DL¹,

Wh²

2017

IJCNE

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“…For a hand grasp application, finger extension would be achieved using a multipolar cuff applied to the radial nerve, while flexion of the fingers would mainly be activated by a another multipolar cuff applied to the median nerve. Demonstrations of the effectiveness of multipolar cuffs have been performed using the sciatic nerve in cats (Grill and Mortimer 1996) and using the optic nerve in man (Veraart et. al.…”

Section: Introductionmentioning

confidence: 99%

Addition of an intrafascicular electrode at the site of application of a multipolar nerve cuff enhances the opportunity for selective fascicular activation

Riso¹,

Dalmose²,

Stefania³

et al. 2001

2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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Abstract-Multipolar nerve cuffs are being developed to apply to peripheral trunk nerves in an effort to limit the number of implanted components of an FES system, while at the same time allowing specific fascicles within the cuffed nerve to be independently activated. Because the electrode contact sites of a multipolar circumferential fitted cuff are positioned only at the surface of the cuffed nerve, it is difficult to activate fascicules that are located deep within the nerve. This situation might be improved if one or more additional electrode contacts were provided within the core of the nerve. An obvious choice for such a contact is to use an intrafascicular electrode (IFE) such as those described by Horch and his colleagues. In our present study we inserted a single IFE into a trunk nerve that subserves the forelimb muscles in an adult anesthetize pig. An 18 pole multichannel nerve cuff was then applied to the nerve at the same site. We stimulated different combinations of the cuff contact sites with and without the IFE while monitoring the evoked EMGs from an array of innervated forearm and shoulder muscles to assess the ability to activate different fascicles independently. The results have shown that the use of the IFE in combination with the normal cuff contacts can afford modest improvements in the degree of selective muscle activation that is possible.

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“…Since that time, a number of research groups have begun the development of retinal prostheses [2,3,4,5,6,7,8]. Some groups are working toward a device that will be implanted on the epiretinal retinal surface while others are developing a subretinal implant.…”

Section: Introductionmentioning

confidence: 99%

Intraocular retinal prosthesis test device

Scribner

Humayun

Justus

et al.

2001 Conference Proceedings of the 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society

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-There is a growing interest in the development of a retinal prosthesis device based on a number of recent experiments demonstrating electrical stimulation of retinal tissue with single electrodes. An intraocular retinal prosthesis test device is currently under development at NRL/JHU. The microelectronic device has an image format of 80 X 40 unit cells interfaced to the retinal surface via an array of microwires in a glass matrix. The system architecture and technology development issues are discussed as well as the topic of biocompatibility. This test device will enable acute human experiments in an operating room environment to demonstrate a massively parallel interface between retinal tissue and a microelectronic array. Keywords -Retina, prosthesis, channel glass, multiplexer 1. INTRODUCTION Recent advances in the fields of microelectronics, neurophysiology, and retinal surgery have progressed to the point where an implantable visual prosthesis system, based on electrical stimulation, is now considered feasible. Currently a number of research projects around the world are aimed at developing prosthetic vision systems. The device discussed in this paper addresses the technical problem of positioning a high-density electrode array against the retina to achieve high-resolution retinal stimulation and perception of image sequences in the patient.The outermost layer of the sensory retina consists of photoreceptors; in the macular region, the photoreceptors are mostly cones (color-sensitive). The next layers of the sensory retina are the bipolar, amacrine, horizontal, and the ganglion cells. The axons of the ganglion cells form the optic nerve.Photoreceptor loss from diseases such as retinitis pigmentosa and age-related macular degeneration are the leading causes of legal blindness. Despite near-total loss of photoreceptors, there is relative preservation of the other retinal neurons. By stimulating the remaining functional retinal layers, it may be possible to restore visual perception.Initial experiments with intraocular stimulation, were performed by de Juan and Humayun several years ago [I]. Since that time, a number of research groups have begun the development of retinal prostheses [2,3,4,5,6,7,8]. Some groups are working toward a device that will be implanted on the epiretinal retinal surface while others are developing a subretinal implant.Epiretinal implantation has the advantage of leaving the retina intact by placing the implant in the vitreous cavity, a naturally existing and fluid-filled space. Studies at John Hopkins University Hospital have demonstrated that this array position is biocompatible [9]. Subretinal implantation of a retinal prosthesis essentially replaces the diseased photoreceptors with a microelectronic stimulator device. However, the surgical implantation requires detaching the retina, and the location of the device may be disruptive to the health of the retina.Section 2 gives an overview of the intraocular retinal prosthesis (IRP) concept and associated electrical stimul...

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Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode

Cited by 373 publications

References 9 publications

A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

A Treatise of the Physical Aspects of Phosphenes and Single-Cell Selectivity in Retinal Stimulation

Addition of an intrafascicular electrode at the site of application of a multipolar nerve cuff enhances the opportunity for selective fascicular activation

Intraocular retinal prosthesis test device

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