Visual Prognostic Value of Optical Coherence Tomography and Photopic Negative Response in Chiasmal Compression

Abstract

An eye with the more demonstrable structural deterioration, as shown by reduced RNFL thickness and GCC area, and retinal ganglion cell dysfunction as shown by decreased PhNR/b-wave amplitude ratio was associated with the worse visual fields outcome. RNFL thickness and GCC area measurements using OCT and PhNR/b-wave amplitude ratio could be a useful prognostic indicator in the preoperative assessment of chiasmal compression.

Longitudinal Analysis of Visual Outcomes After Surgical Treatment of Adult Craniopharyngiomas

“…This irreversibility of visual outcome in CRP patients may be due to the structural damage of retinal nerve fibers caused by chronic compression of the tumor on anterior optic nerve pathway. 24 …”

Finite Element Modeling of Optic Chiasmal Compression

“…Crossing results in a much smaller contact area between neurons and, therefore, a much greater stress on the crossing fibers for any given compressive force applied to the chiasm (5). Recent studies have looked at factors that can predict outcome after treatment, such as the degree of nerve fiber loss at the optic disc (6,7). A better understanding of the exact mechanism involved has significant implications for management and prognosis and may have more wide-reaching implications for other forms of neural compression involving nerve fibers traveling in different directions (e.g., in the spinal cord).…”

OCT and Compressive Optic Neuropathy

“…In one study, we have also shown that OCT measurements correlated well both with VF and pattern electroretinogram in patients with chiasmal compression [ 47 ]. Moon et al [ 48 ] showed an important correlation between reduced RNFL thickness and decreased b wave on photopic negative response, both associated with worse VF outcome. Therefore OCT can also be associated with other electrophysiological methods as prognostic indicator in the preoperative assessment of chiasmal compression.…”