Finite Element Modeling of Optic Chiasmal Compression

Wang, Xiao Fei; Neely, Andrew J.; McIlwaine, Gawn G.; Tahtalı, Murat; Lillicrap, Thomas; Lueck, Christian J.

doi:10.1097/wno.0000000000000145

Cited by 19 publications

(18 citation statements)

References 19 publications

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“…The biomechanism of OC compression was studied by Wang et al () using finite element modeling of the OC. He demonstrated that a tumor growing below the OC strains the nasal (crossed) fibers more than the temporal (uncrossed) fibers.…”

Section: Discussionmentioning

confidence: 99%

“…Authors have attempted to explain the bitemporal hemianopia caused by tumor compression from below the OC. Two hypotheses have been proposed: stretching fibers of the OC (Moon et al, 2011;Kidd, 2014;Wang et al, 2014) and alteration of the OC blood supply (Blunt and Steele, 1956;Bergland, 1969;Dawson, 1958). Nevertheless, some authors have described anastomoses between the superior and inferior pial network (Collette et al, 1956;Bergland, 1969;Wollschlaeger et al, 1971;Kidd, 2014).…”

Section: Extrinsic Blood Supply Of the Ocmentioning

confidence: 99%

“…The biomechanism of OC compression was studied by Wang et al (2014) using finite element modeling of the OC. He demonstrated that a tumor growing ACoA n 5 10 ACA (A1) n 5 10 0 0/13 1/13 1/10 0/10 1 3/13 3/13 4/10 5/10 2 4/13 6/13 5/10 4/10 3 3/13 3/13 1/10 4 2/13 5 0/13 6 1/13 ACA, Anterior cerebral artery; A1, first segment of ACA; ACoA, anterior communicating artery; PCoA, posterior communicating artery; SupHypA, superior hypophyseal artery.…”

Section: Clinical Implications Of the Optic Chiasm Blood Supplymentioning

confidence: 99%

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Extrinsic and intrinsic blood supply to the optic chiasm

et al. 2017

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Although there have been many studies of the arterial cerebral blood supply, only seven have described the optic chiasm (OC) blood supply and their results are contradictory. The aim of this study was to analyze the extrinsic and intrinsic OC blood supply on cadaveric specimens using dissections and microcomputer tomography (Micro-CT). Thirteen human specimens were dissected and the internal or common carotid arteries were injected with red latex, China Ink with gelatin or barium sulfate. Three Micro-CTs were obtained to reveal the intrinsic blood supply to the OC. The superior hypophyseal arteries (SupHypA) (13/13) and posterior communicating artery (PCoA) (12/13) supplied the pial network on the inferior side of the OC. The first segment of the anterior cerebral artery (ACA) (10/10), SupHypA (7/10), the anterior communicating artery (ACoA) (9/10), and PComA (1/10) supplied the pial network of its superior side. The intrinsic OC blood supply was divided into three networks (two lateral and one central). Capillaries entering the OC originated principally from the inferior pial network. The lateral network capillaries had the same orientation as the visual lateral pathways, but the central network was not correlated with the nasal fibers crossing into the OC. There was no anastomosis in the pial or intrinsic networks. Only SupHypA, PCoA, ACoA, and ACA were involved in the OC blood supply. Because there was no extrinsic or intrinsic anastomosis, all arteries should be preserved. Tumor compression of the inferior intrinsic arterial network could contribute to visual defects. Clin. Anat. 31:432-440, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Section: Extrinsic Blood Supply Of the Ocmentioning

confidence: 99%

Section: Clinical Implications Of the Optic Chiasm Blood Supplymentioning

confidence: 99%

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Extrinsic and intrinsic blood supply to the optic chiasm

et al. 2017

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“…The retrobulbar optic nerve is supplied primarily by the ophthalmic artery and surrounded by three meningeal layers . Diseases that commonly affect the optic nerve include optic neuritis (which can be secondary to multiple sclerosis) and glaucoma . The most common disease affecting the retrobulbar optic nerve is retrobulbar optic neuritis.…”

Section: Unambiguous Protein Isoforms Identified In Human Optic Nervementioning

confidence: 99%

The proteome of normal human retrobulbar optic nerve and sclera

et al. 2016

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The optic nerve is a white matter tract that conveys visual information to the brain. The sclera comprises the white, protective outer layer of the eye. A characterization of the proteome of normal human retrobulbar optic nerve and sclera may facilitate studies of the eye. We conducted a proteomic analysis of optic nerve and sclera from five adults. Proteins were fractionated using SDS-PAGE. After in-gel digestion, peptides were analyzed using LC-MS/MS on an Orbitrap Elite mass spectrometer. We identified 2711 non-redundant proteins in retrobulbar optic nerve and 1945 non-redundant proteins in sclera. Optic nerve proteins included proteins expressed by oligodendrocytes (laminin, proteolipid protein, fibronectin), myelin proteins (myelin basic protein, myelin-associated glycoprotein), and paranodal structural proteins (ankyrin β, spectrin). Sclera included 18 collagen protein chains, small leucine-rich proteoglycans (decorin, biglycan, lumican, keratocan, prolargin, fibromodulin, mimecan), non-collagenous glycoproteins (fibronectin, vitronectin, laminin), extracellular matrix proteins (thrombospondins 1-4, dystroglycan, transgelins 1-3), and integrins alpha-V, alpha-1 and 2, beta-1, -2, and -5. Twenty-one unambiguous alternative splicing protein isoforms were identified in optic nerve and ten unambiguous alternative splicing protein isoforms were identified in sclera. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with the dataset identifier PXD001581.

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“…10 Engineering models have also suggested that this pressure gradient may be responsible for creating a bitemporal hemianopia clinically. 11 Progression of visual loss from involvement of the optic chiasm, particularly with compression due to suprasellar lesions, often proceeds in a stereotypical fashion. Initially the superotemporal visual fields are affected followed by the inferotemporal, the inferonasal, and then the superonasal fields.…”

Section: Visual Lossmentioning

confidence: 99%

Visual Findings in Chiasmal Syndromes

Foroozan¹

2016

International Ophthalmology Clinics

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The optic chiasm is an important neuroanatomic landmark, in particular as it relates to the pituitary gland and endocrinologic syndromes. Pathology that affects the chiasm helps emphasize key principles of neuroanatomy. The most common visual consequence of pituitary tumors is chiasmal compression, and visual findings remain important indicators of central nervous system pathology in many patients with sellar/suprasellar lesions.In this review, I have illustrated several different clinical syndromes that ensue from pathology involving the optic chiasm and discussed the various etiologies of chiasmal pathology. In addition, I have provided several examples of the neuroimaging findings that highlight the anatomy and pathology involving the optic chiasm.I hoped to provide a logical basis for the practicing ophthalmologist in approaching chiasmal disorders. ' AnatomyThe intracranial optic nerves exit the optic canals and travel at a 30-to 45-degree angle to make up the optic chiasm. The optic chiasm is 12 to 18 mm in diameter and contains the decussation of nasal retinal nerve fibers from each of the optic nerves. 1 Inferior retinal fibers representing the superior visual field cross first, whereas macular fibers cross more posteriorly. The chiasm lies 10 mm above the sella turcica, which contains the pituitary gland (Fig. 1).The space inferior to the chiasm and above the sella is the basal cistern. Anteriorly, the chiasm is exposed to cerebrospinal fluid; posteriorly it abuts the hypothalamus and the anterior portion of the third ventricle. The anatomic position of the chiasm is described as

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Finite Element Modeling of Optic Chiasmal Compression

Cited by 19 publications

References 19 publications

Extrinsic and intrinsic blood supply to the optic chiasm

Extrinsic and intrinsic blood supply to the optic chiasm

The proteome of normal human retrobulbar optic nerve and sclera

Visual Findings in Chiasmal Syndromes

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