Visual prognosis of coats' disease

A population-based study of Coats disease in the United Kingdom I: epidemiology and clinical features at diagnosis

“…The comparable figures for the series reported by Shields, Cahill, and Budning are 27, 74, and 44%, respectively. 1,7,9 The anterior segment findings at baseline examination (not just as the presenting feature) in our series reflect the less severe or advanced nature of Coats disease compared with Shields. We found an incidence of leucocoria of 20% while Shields reported 24%.…”

“…7 In the series reported by Budning et al, the comparable figure is 88%. 9 Our figure of just 44% of eyes with very poor vision at presentation is the lowest reported. The levels of very poor vision at presentation also concur with the number of clock hours of retinal exudation.…”

“…1,7,[9][10][11] While previous studies have been Coats disease in the United Kingdom 1: epidemiology and presenting features B Morris et al enlightening they did not seem to reflect the cases of Coats disease we have typically encountered in clinical practise. On the other hand, the smaller numbers in our study could make the differences observed to be a chance rather than a real occurrence.…”

A population-based study of Coats disease in the United Kingdom II: investigation, treatment, and outcomes

“…Two series from large tertiary referral centres have significantly worse proportions of eyes with very poor vision; 64% for Shields (Wills Eye Hospital, Philadelphia, PA, USA) 5 and 96% for Budning (Hospital for Sick Children, Toronto, ON, Canada). 3 We have shown that it is possible to achieve stabilisation or improvement of the Coats staging in virtually nearly all cases (98%). The disease stage at diagnosis is therefore a highly important prognostic factor in this series.…”

“…1 More advanced cases may progress to complete retinal detachment, neovascular glaucoma, and sometimes require enucleation. [1][2][3] Although there are published case series of Coats disease, no populationbased studies have been performed. We have conducted a prospective population-based study of Coats disease in the United Kingdom to provide a balanced picture of the disease spectrum.…”