Visual outcomes following cataract surgery in age-related macular degeneration patients

Chen, Andrew X.; Haueisen, Alexander; Rasendran, Chandruganesh; Hom, Grant L; Conti, Thais F.; Conti, Felipe F.; Greenlee, Tyler; Briskin, Isaac; Bena, James; Singh, Rishi P.; Talcott, Katherine E.

doi:10.1016/j.jcjo.2021.01.018

Cited by 5 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are reports that focal RPE atrophy at the location of type 3 neovascularisation is in fact predictive of a favourable visual outcome (0.70 ± 0.48 LogMAR) compared with non-focal RPE atrophy (1.12 ± 0.68 LogMAR), with more participants loosing >3 lines ETDRS after 37 months [ 70 ]. Conversely, effects of RPE thickening are currently mixed with a suggestion this is significantly associated with progression to advanced AMD and neovascularisation [ 60 ] yet not associated with the risk of progression by others [ 73 ].…”

Section: Key Retinal Biomarkersmentioning

confidence: 99%

Optical coherence tomography imaging biomarkers associated with neovascular age-related macular degeneration: a systematic review

Hanson

Airody

Sivaprasad

et al. 2022

Eye

View full text Add to dashboard Cite

The aim of this systematic literature review is twofold, (1) detail the impact of retinal biomarkers identifiable via optical coherence tomography (OCT) on disease progression and response to treatment in neovascular age-related macular degeneration (nAMD) and (2) establish which biomarkers are currently identifiable by artificial intelligence (AI) models and the utilisation of this technology. Following the PRISMA guidelines, PubMed was searched for peer-reviewed publications dated between January 2016 and January 2022. Population: Patients diagnosed with nAMD with OCT imaging. Settings: Comparable settings to NHS hospitals. Study designs: Randomised controlled trials, prospective/retrospective cohort studies and review articles. From 228 articles, 130 were full-text reviewed, 50 were removed for falling outside the scope of this review with 10 added from the author’s inventory, resulting in the inclusion of 90 articles. From 9 biomarkers identified; intraretinal fluid (IRF), subretinal fluid, pigment epithelial detachment, subretinal hyperreflective material (SHRM), retinal pigmental epithelial (RPE) atrophy, drusen, outer retinal tabulation (ORT), hyperreflective foci (HF) and retinal thickness, 5 are considered pertinent to nAMD disease progression; IRF, SHRM, drusen, ORT and HF. A number of these biomarkers can be classified using current AI models. Significant retinal biomarkers pertinent to disease activity and progression in nAMD are identifiable via OCT; IRF being the most important in terms of the significant impact on visual outcome. Incorporating AI into ophthalmology practice is a promising advancement towards automated and reproducible analyses of OCT data with the ability to diagnose disease and predict future disease conversion.Systematic Review Registration: This review has been registered with PROSPERO (registration ID: CRD42021233200).

show abstract

Section: Key Retinal Biomarkersmentioning

confidence: 99%

Optical coherence tomography imaging biomarkers associated with neovascular age-related macular degeneration: a systematic review

Hanson

Airody

Sivaprasad

et al. 2022

Eye

View full text Add to dashboard Cite

show abstract

“…registry identified that the angiographic subtype of neovas-cular AMD did not impact the visual outcomes of cataract surgery [17]. Prognostic factors in patients with AMD undergoing cataract surgery have recently been investigated in a retrospective study [19]. Better pre-operative VA predicted smaller VA gains (p < 0.007).…”

Section: Predicting Visual Acuity Outcomesmentioning

confidence: 99%

Management of Cataract in Patients with Age-Related Macular Degeneration

Mehta

2021

JCM

View full text Add to dashboard Cite

Cataract and age-related macular degeneration (AMD) are two of the most common eye diseases of aging. This review addresses the pre-operative, intra-operative, and post-operative considerations in managing cataract in patients with age-related macular degeneration. Surgery for visually significant cataracts in patients with AMD can substantially improve the quality of life and reduce the risk of falls. Pre-operative optical coherence tomography is now recommended where possible to identify pre-existing macula disease. Careful counselling of patients is required before cataract surgery, especially with respect to the expected visual outcome, intraocular lens choice and potential risks of surgery. Real-world data has suggested 6 months of intravitreal anti-VEGF therapy for neovascular AMD before cataract surgery is compatible with optimum long-term visual outcomes. Patients receiving intravitreal therapy for neovascular AMD should be advised of the slightly higher risk of intraoperative complications and the surgeon should be prepared to manage these during the operation. During cataract surgery, unnecessary light exposure should be avoided to reduce phototoxicity. Careful planning of intravitreal therapy for neovascular AMD just before cataract surgery allows the eye greater recovery time in the post-operative period before further planned intravitreal therapy.

show abstract

Cataract surgery in patients with age-related macular degeneration

Sivaprasad

2021

Canadian Journal of Ophthalmology

View full text Add to dashboard Cite

Visual outcomes following cataract surgery in age-related macular degeneration patients

Cited by 5 publications

References 29 publications

Optical coherence tomography imaging biomarkers associated with neovascular age-related macular degeneration: a systematic review

Optical coherence tomography imaging biomarkers associated with neovascular age-related macular degeneration: a systematic review

Management of Cataract in Patients with Age-Related Macular Degeneration

Cataract surgery in patients with age-related macular degeneration

Contact Info

Product

Resources

About