Management of Cataract in Patients with Age-Related Macular Degeneration

Mehta, Hemal

doi:10.3390/jcm10122538

Cited by 7 publications

(9 citation statements)

References 59 publications

(71 reference statements)

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“…Moreover, previous studies have reported elevated levels of VEGF in cataract patients ( Mitrović et al, 2016 ), which is inconsistent with our findings. In cases where patients are preparing for cataract surgery, anti-VEGF drugs are often required to enhance postoperative vision recovery ( Zhao and Cheng, 2019 ; Mehta, 2021 ). We speculate that the decrease in systemic VEGF levels found in individuals with cataract in our study could be attributed to anti-VEGF treatment.…”

Section: Discussionmentioning

confidence: 99%

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Teng,

Wang,

et al. 2024

Front. Aging Neurosci.

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BackgroundPrevious studies have explored the associations between circulating inflammatory cytokines and blinding eye diseases, including glaucoma, cataract and macular degeneration. However, the causality of these associations remains controversial. This study employs a bidirectional Mendelian randomization (MR) study to investigate the causal relationships between 41 circulating inflammatory cytokines and these blinding eye diseases.MethodsSummary data for glaucoma, cataract, macular degeneration and 41 circulating inflammatory cytokines were publicly available. The inverse variance weighted (IVW) method was employed as the main analysis method. Additionally, various sensitivity tests, including MR–Egger regression, weighted median, weight mode, Cochran’s Q test, MR pleiotropy Residual Sum and Outlier test, and leave-one-out test, were conducted to evaluate sensitivity and stability of results.ResultsThe IVW analysis identified six circulating inflammatory cytokines causally associated with the risk of blinding eye diseases: Monokine induced by interferon-gamma (MIG) for glaucoma, interleukin-1 receptor antagonist (IL-1ra), IL-6, IL-10, and platelet derived growth factor BB (PDGFbb) for cataract, and MIG and hepatocyte growth factor (HGF) for macular degeneration. However, it is noteworthy that none of these associations remained significant after Bonferroni correction (p < 0.0004). Reverse MR analyses indicated that cataract may lead to a decrease in vascular endothelial growth factor (VEGF) levels (OR: 3.326 × 10−04, 95% CI: 5.198 × 10−07 − 2.129 × 10−01, p = 0.0151).ConclusionThis study highlights the potential roles of specific inflammatory cytokines in the development of glaucoma, cataract and macular degeneration. Moreover, it suggests that VEGF is likely to be involved in cataract development downstream. These findings offer insights for early prevention and novel therapeutic strategies for these blinding eye diseases.

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Section: Discussionmentioning

confidence: 99%

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Teng,

Wang,

et al. 2024

Front. Aging Neurosci.

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“…In this study, we found similar results for toric IOLs in FECD eyes compared with healthy eyes. The expanding indications for the implantation of toric IOLs in eyes with comorbidities such as AMD and even corneal ectasias such as keratoconus enables more patients to be spectacle independent and enjoy a higher quality of vision [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…However, toric IOL implantation is more predictable and precise, can fix a higher corneal astigmatism, can achieve more spectacle independence, and can provide a higher quality of vision without image distortion compared to the other methods [1,2,5,6]. Recently, the implantation of toric IOLs in eyes with comorbidities has burgeoned, and patients with age-related macular degeneration (AMD), as well as patients with mild to moderate corneal ectasias, are being offered toric IOLs and spectacle independence with satisfactory refraction results [6][7][8]. However, the implantation of toric IOLs in patients with corneal dystrophies such as FECD is still considered by some surgeons to be contraindicated, which lacks supporting clinical evidence [6].…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of Toric Intraocular Lenses in Patients with Fuchs Endothelial Corneal Dystrophy

Blau-Most

Levy²,

Assia

et al. 2023

Ophthalmol Ther

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Introduction: Implantation of toric intraocular lenses (IOLs) in patients with Fuchs endothelial corneal dystrophy (FECD) is still considered relatively contraindicated, without sufficient clinical evidence. Therefore, this study was designed to evaluate the results of toric IOL implantation in patients with FECD. Methods: A retrospective case-control study of 28 eyes of FECD patients and 84 eyes of healthy control patients who received toric IOLs during routine cataract surgery was performed. The outcome measures were uncorrected and corrected distance visual acuity, spherical equivalent, and refractive residual astigmatism. Results:The mean postoperative uncorrected and corrected distance visual acuity in the FECD eyes compared to the control eyes were 0.15 ± 0.14 vs. 0.13 ± 0.17, respectively (P = 0.32), and 0.05 ± 0.08 vs. 0.06 ± 0.10, respectively (P = 0.95). The spherical equivalent in the FECD eyes compared to the control eyes was -0.29 ± 0.43 vs. -0.21 ± 0.50, respectively (P = 0.19). The preoperative corneal centroid astigmatism in the FECD eyes compared to the control eyes was 0.85 D@93°± 2.42°vs. 0.23 D@68°± 2.50°, respectively (P = 0.43), and the mean preoperative corneal astigmatism magnitude was 2.26 ± 1.1 D vs. 2.28 ± 1.03 D, respectively (P = 0.82). A trend toward higher postoperative refractive centroid astigmatism was found in the FECD eyes compared with the control eyes: 0.24 D@28°± 0.57°vs. 0.03 D@127°± 0.53°, respectively (P = 0.09). However, the mean refractive astigmatism magnitude was similar in FECD eyes and the healthy control eyes: 0.52 ± 0.31 D vs. 0.42 ± 0.31 D, respectively (P = 0.44). Conclusion:The postoperative refractive astigmatism (both centroid astigmatism and mean magnitude astigmatism) was no higher than 0.52 D in both groups. Therefore, FECD patients without corneal edema can be considered for toric IOLs.

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“…Two of the most widespread eye diseases of aging and the most important causes of vision loss are cataract and age-related macular degeneration (AMD) [1][2][3].…”

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confidence: 99%

Choroidal structural changes after phacoemulsification in eyes with age-related macular degeneration

Sevimli,

Alis

2023

j-ebr

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To evaluate the changes in choroidal vascular structures in patients with dry age-related macular degeneration (AMD) and healthy controls (No-AMD) after phacoemulsification. Methods: This prospective study was conducted in 34 eyes of 19 patients in the AMD group and 32 eyes of 20 patients in the no-AMD group who had uneventful phacoemulsification. Best-corrected visual acuity, slitlamp biomicroscopy, and intraocular pressure were recorded. Choroidal thickness (CT) measurements of the subjects were obtained using enhanced depth imaging optical coherence tomography (Edi-OCT) (RS-3000 Advance, Nidek, Japan), and choroidal vascular index (CVI) was calculated by using the binarization method at baseline and postoperatively at months 1 (M1) and 3 (M3) and the results were compared. Results: There was no significant difference between the patients in terms of age and gender (p=0.069, p=0.855 respectively). The mean CVI at baseline was 0.644 ± 0.019% in the AMD group and 0.657 ± 0.021% in the no-AMD group (p=0.025). In the AMD group, the CVI increased significantly in M3 compared to preoperative values (p=0.001). There was no significant difference between the two groups in terms of CT in baseline, M1, and M3 (p0.05). There was a significant increase in CT in M1 compared to preoperative values in both groups (p=0.026 and p=0.050, respectively). Conclusion: Although the preoperative CVI was lower in the AMD group than in the no-AMD group, there was a greater increase in CVI after phacoemulsification in the AMD group. While CT values return to normal after phacoemulsification sooner, CVI remains elevated for a longer period.

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Management of Cataract in Patients with Age-Related Macular Degeneration

Cited by 7 publications

References 59 publications

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis

Clinical Outcomes of Toric Intraocular Lenses in Patients with Fuchs Endothelial Corneal Dystrophy

Choroidal structural changes after phacoemulsification in eyes with age-related macular degeneration

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